CAS: 23056-39-5; 2-Chloro-4-Methyl-3-Nitropyridine

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CAS号21901-18-8 2-羟基-4-甲基-3-硝基吡啶 | CAS号6635-86-5 2-氨基-4-甲基-3-硝基吡啶 | CAS号10026-13-8 五氯化磷 | CAS号695-34-1 2-氨基-4-甲基吡啶 | CAS号393-53-3 3-氟吡啶-4-羧酸 | CAS号59290-82-3 3-硝基异烟酸 | CAS号3430-27-1 3-氨基-4-甲基吡啶 | CAS号5832-44-0 4-甲基-3-硝基吡啶 | CAS号174532-77-5 3-Formyl Nevirapine | CAS号399-88-2 3-氟-4-甲基吡啶 | CAS号284686-19-7 2-Chloro-N-[2-(... | CAS号284686-20-0 N-[5-溴-2-(环丙基氨基... | CAS号284686-18-6 N2-Cyclopropyl-... | CAS号867034-10-4 7-氯-1H-吡咯并[2,3-...

2-氨基-3-硝基-4-甲基吡啶置于硫酸,Sodium Nitrite,三氯氧磷体系中,用 水 用作溶剂,化学反应生成2-氯-4-甲基-3-硝基吡啶
参考文献:许多新的取代的吡唑并[3,4-C]吡啶的合成,对接研究和激酶抑制活性.
标题:许多新的取代的吡唑并[3,4-C]吡啶的合成,对接研究和激酶抑制活性.
摘要:设计并合成了一系列带有各种1,3,5或1,3,7个图案取代的新型吡唑并[3,4-C]吡啶.它们中的一些显示出有趣的抑制活性,主要针对糖原合酶激酶3(gsk3)alpha / Beta以及针对cdc2样激酶1(clk1)和双特异性酪氨酸磷酸化调节激酶1A(dyrk1A),具有非常好的选择性和显着性结构-活性关系(sars),无细胞毒性.与生物学数据相关的分子模拟揭示了n1-H的存在以及不存在庞大的7位取代基的重要性.
Doi:10.1248/cpb.C16-00704

专利信息

专利号:US-8188282-B2
优先权日:2006-07-15
标 题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

专利号:WO-2023098592-A1
优先权日:2021-11-30
标题:Preparation method for carbon-loaded iron-based catalyst and use thereof in synthesis of intermediates of anti-cancer inhibitors

专利号:US-6111112-A
优先权日:1999-01-22
标题 :Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone
发明人：GROZINGER KARL
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A method for making 3-amino-2-chloro-4-methylpyridine from malononitrile, as depicted in the following reaction scheme. ##STR1##

专利号:US-6136982-A
优先权日:1999-01-22
标 题:Synthesis of 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate
发明人：GROZINGER KARL
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A method for making 3-amino-2-chloro-4-methylpyridine from acetone and ethyl cyanoacetate, as depicted in the following reaction scheme. ##STR1##

专利号:CN-114315595-B
优先权日:2021-11-30
标题 :Preparation method of a carbon-supported iron-based catalyst and its application in the synthesis of anti-cancer inhibitor intermediates

专利号:AU-2007276514-A1
优先权日:2006-07-15
标题:A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles