CAS: 20487-40-5; Tert-Butyl Propionate

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19136-91-5 60153-92-6 14036-55-6

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CAS号1663-39-4 丙烯酸叔丁酯 | CAS号79-03-8 丙酰氯 | CAS号75-65-0 叔丁醇 | CAS号109-69-3 1-氯丁烷 | CAS号111757-80-3 (S)-tBu-lactic ... | CAS号201230-82-2 carbon monoxide | CAS号554-12-1 丙酸甲酯 | CAS号865-47-4 叔丁醇钾 | CAS号123-62-6 丙酸酐 | CAS号5545-52-8 N-苄氧羰基-L-天门冬氨酸 4-叔丁酯 | CAS号42417-76-5 Z-L-天冬氨酸叔丁酯叔丁酯 | CAS号516-09-6 4-羟基-3-甲基呋喃-2(5H)-酮 | CAS号108-94-1 环己酮 | CAS号2901-11-3 Benzeneacetic a... | CAS号26735-86-4 tert-butyl 2-me... | CAS号87573-44-2 tert-butyl (Z)-... | CAS号4984-85-4 4-羟基-3-己酮 | CAS号2531-80-8 2-硝基丙酸乙酯

📜丙烯酸叔丁酯置于氢气体系中,用 乙醇 用作溶剂,40.0 °C,400.01 Kpa 条件下,反应 5.0H,反应生成丙酸叔丁酯
参考文献:聚离子液体上负载的钯纳米粒子的结构,电子和催化性能
标题:聚离子液体上负载的钯纳米粒子的结构,电子和催化性能
摘要:在α,β选择性加氢中,研究了通过溅射沉积和化学还原pd(II)前体在聚离子液体(pil)中/之上对钯纳米颗粒(pd Nps)的结构,电子和支持作用.-不饱和羰基化合物和二烯.溅射沉积会生成裸露的np,其粒径分布较窄(3.2-3.8 Nm),主要由pd(0)(85-100%)组成.相反,化学还原产生的pil覆盖的np几乎是平均大小(6.6 Nm)的两倍,而pd(0)仅为15%.关于催化性能,载体组成(是否通过离子液体(il)添加)和np位置是决定性的.在pil / Il混合物(d-Mpil.Ntf 2/ Il-Pd催化剂).使用2-环己烯-1-酮(chn)和d-Mpil.Ntf 2 / Il-Pd催化剂进行了动力学研究,表明该反应遵循langmuir-Hinshelwood机理.从van'T Hoff图获得的焓表明,Chn底物在pil-Pd催化剂表面的吸附是放热过程(-9 Kj Mol-1),而h
Doi:10.1016/j.Apcata.2018.06.001

专利信息

专利号:US-8153839-B2
优先权日:2005-09-14
标题:Method for synthesis of keto acids or amino acids by hydration of acetylene compound
发明人：OGO SEIJI; FUKUZUMI SHUN-ICHI
权利人:OGO SEIJI; FUKUZUMI SHUN-ICHI; JAPAN SCIENCE & TECH AGENCY
摘要:An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylene-carboxylic acids in a single container (one-pot or tandem synthesis). In one embodiment of the method according to the present invention for synthesis of keto acids, acetylene-carboxylic acids is hydrated in the presence of a metal salt represented by General Formula (1), n nwhere M 1 represents an element in Group VIII, IX, or X of the periodic table, and X 1 , X 2 , or X 3 ligand represents halogen, H 2 O, or a solvent molecule, and k represents a valence of a cation species, and Y represents an anion species, and L represents a valence of the anion species, and each of K and L independently represents 1 or 2, and k×m=L×n.

专利号:US-8173817-B2
优先权日:2004-05-28
标 题 :Stereoselective synthesis of benzimidazole sulfoxides
发明人：REDDY BANDI PARTHASARADHI; REDDY KURA RATHNAKAR; REDDY RAPOLU RAJI; REDDY DASARI MURALIDHARA
权利人:REDDY BANDI PARTHASARADHI; REDDY KURA RATHNAKAR; REDDY RAPOLU RAJI; REDDY DASARI MURALIDHARA; HETERO DRUGS LTD
摘要:The present invention relates to a process for stereoselective synthesis of substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazole is reacted with (R)-camphorsulfonyl chloride to form a mixture of 1-(R)-camphorsulfonyl-5- (and 6-)methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]-1H-benzimidazole, oxidized to obtain a diastereomeric excess of 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole over 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R)-sulfinyl]-1H-benzimidazole, the diastereomers are separated by fractional crystallization and the separated 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole is deprotected to give esomeprazole.

专利号:US-7960578-B2
优先权日:2007-03-21
标题:Method for the synthesis of peptides without solvent
发明人：MARTINEZ JEAN; LAMATY FREDERIC; DECLERCK VALERIE
权利人:CENTRE NAT RECH SCIENT; UNIV MONTPELLIER I
摘要:The disclosure relates to a method for the synthesis of a compound of the formula (I) in which: n is an integer higher than or equal to 1; Rb and each Rn are independently a hydrogen atom, a C 1 -C 6 arylalkyl group or a C 1 -C 6 alkyl group substituted or not by an aryl group, —COOH, C 1 -C 6 , —COO-(alkyl), —CONH 2 , —SH, heteroaryl, —NH 2 , —NHC(NH)(NH 2 ), C 1 -C 6 -s-(alkyl), —OH or phenol; Ra is a N-protective group; Rc is a ORd group in which Rd is a C 1 -C 6 alkyl group or a NReRf group in which Re and Rf Re independently an N-protective group.

专利号:US-9982005-B2
优先权日:2013-04-04
标 题 :Macrolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides. Intermediates in the synthesis of macrolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using the inventive macrolides are also provided. A general diastereoselective aldol methodology used in the synthesis of the western half is further provided.

专利号:US-11466046-B2
优先权日:2014-10-08
标题 :14-membered ketolides and methods of their preparation and use
发明人：MYERS ANDREW G; SEIPLE IAN BASS; ZHANG ZIYANG
权利人:HARVARD COLLEGE
摘要:Provided herein are methods of preparing new 14-membered ketolides via coupling of an eastern and western half moiety, followed by macrocyclization, and optional functionalization. Intermediates in the synthesis of these ketolides including the eastern and western halves are also provided. Pharmaceutical compositions and methods of treating infectious diseases and inflammatory conditions using these ketolides are also provided.

专利号:US-6462221-B1
优先权日:1999-02-23
标 题 :Synthesis of nitroalcohol diastereomers
发明人：GABRIEL RICHARD L; MOUSSA ADEL M; FITZHENRY SHARON; LIU CHANGHUA; SWANSON DAVID A; LA BRITTANY; ZAHR SALAH; SACHDEVA YESH P; JURAYJ JURJUS
权利人:JOHNSON MATTHEY PHARMACEUTICAL
摘要:The present invention relates to a method of preparing a 1-nitro-3-substituted-3-amino-2-propanol diastereomer represented by Structural Formula I:In Structural Formula I, R is an amine protecting group, and R1 is an amino acid side-chain, a protected amino acid side-chain, a substituted or unsubstituted aliphatic group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted heteroaromatic group, a substituted or unsubstituted aralkyl or a substituted or unsubstituted heteroaralkyl group. The method involves contacting a 1-nitro-3-substituted-3-amino-2-propanone with a reducing agent to form a mixture of 1-nitro-3-substituted-3-amino-2-propanol diastereomers. The 1-nitro-3-substituted-3-amino-2-propanol diastereomers are then separated by simulated moving bed chromatography to obtain one or more 1-nitro-3-substituted-3-amino-2-propanol diastereomer.