CAS: 1839-18-5; 2-Chloro-7H-Purin-6-Amine

上下游产品

CAS号5451-40-1 2,6-二氯嘌呤 | CAS号146-77-0 2-氯腺苷 | CAS号883731-41-7 Adenosine, 2-ch... | CAS号4291-63-8 克拉利宾 | CAS号123318-82-1 克罗拉滨 | CAS号4291-63-8 克拉利宾 | CAS号3373-53-3 异鸟嘌呤 | CAS号28128-30-5 2-甲氧基-7H-嘌呤-6-胺 | CAS号123318-82-1 克罗拉滨 | CAS号115044-75-2 2-chloro-3'-deo... | CAS号24723-77-1 2-甲氧基腺苷 | CAS号7013-21-0 2-氯-9-甲基-9H-嘌呤-6-胺 | CAS号7674-36-4 SQ 21137 | CAS号5404-92-2 9H-Purin-6-amin... | CAS号56046-25-4 9-苄基-2-氯腺嘌呤

克拉屈滨置于溶剂黄146体系中,用 水 用作溶剂,化学反应生成2-氯-6-氨基嘌呤
参考文献:Determination Of 2-Chloro-2'-Deoxyadenosine (Antileukemic Agent) And Related Compounds By Electrochemical Method
标题:Determination Of 2-Chloro-2'-Deoxyadenosine (Antileukemic Agent) And Related Compounds By Electrochemical Method
摘要:Electrochemical Method For Determination Of 2-Chloro-2'-Deoxyadenosine And Related Compounds Modified In Exocyclic 6-Nh2 Group Is Described. Electrochemical Detection Of Investigated Compounds,Based On The Electrooxidation Process Of The Adenine Moiety,Has Been Performed In Aqueous Solutions,In The Ph Range 2-9,On A Glassy Carbon Electrode.
Doi:10.1080/15257779908041649

专利信息

专利号:EP-1709057-B1
优先权日:2004-01-21
标 题:Synthesis of spongosine
发明人：OUZMAN JACQUELINE VALERIE ANNE
权利人:CAMBRIDGE BIOTECHNOLOGY LTD
摘要:Reaction of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose with 2-methoxyadenine to form 9-(2′,3′,5′-tri-O-benzoyl-β-D-ribofuranosyl)-2-methoxyadenine, then deprotection of the 9-(2′,3′,5′-tri-O-benzoyl-β-D-ribofuranosyl)-2-methoxyadenine to form spongosine is described. Synthesis of intermediates for use in the synthesis of spongosine is also described.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-4849513-A
优先权日:1983-12-20
标 题 :Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-5118802-A
优先权日:1983-12-20
标 题:DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER JR ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-2015376219-A1
优先权日:2014-06-30
标题 :Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods
发明人：ZHONG MINGHONG
权利人:ZHONG MINGHONG
摘要:A process of regiospecific synthesis of N-9 purine nucleoside analogs in either solution or solid phase synthesis is described. The introduction of the sugar moiety or its analogue on to a 6-heteroarylium purine or its mesomeric betaine so that formation of only the N-9 position regioisomers of the purine nucleoside analogs (either D or L enantiomers) is obtained. This regiospecific introduction of the sugar moiety allows the synthesis of purine nucleoside analogs in high yields without formation of the N-7-positional regioisomers, while the 6-heteroaryliums are leaving groups facilitated for nucleophilic displacement. Solid supported 6-heterarylium purine bases can be used for purine based library synthesis and synthesis of nucleotide monophosphates and polyphosphates. Processes for providing novel 6-heteroarylium purines and their corresponding mesomeric betaines for the regiospecific synthesis of N-9 purine nucleoside analogs and nucleotides are described.

专利号:US-2024084295-A1
优先权日:2020-12-08
标 题:Novel Synthesis of Phosphorodithioate Oligonucleotides
发明人：BOLLMARK MARTIN; SEHGELMEBLE TORREJON WALTER FERNANDO; SLADOJEVICH FILIPPO; TEDEBARK ULF
权利人:HOFFMANN LA ROCHE
摘要:The invention provides the use of a compound of formula (I), as defined, for the preparation of an oligonucleotide comprising at least one phosphorodithioate internucleoside linkage. Various synthesis methods using compounds of formula (I) are provided.