CAS: 1811-31-0; N-Acetyl-D-Galactosamine

相似化合物

3615-17-6 7512-17-6 7512-17-6

上下游产品

acetic anhydride N-[(2R,3R,4R,5R,6R)-2-((S)-2,3-Dihydroxy-propoxy)-5-hydroxy-6-hydroxymethyl-4-((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-3-yl]-acetamide α-L-Fuc-(1-3)-β-D-GalNAc-(1-3)-β-D-Gal-(1-4)-β-D-Gal-(1-3)-D-GalNAc-ol 2-acetamido-2-deoxy-D-glucose2-acetamido-2-deoxy-D-galacticol trimethylsilyl ether of N-acetylgalactosamine anti-O-metyloxime trimethylsilyl ether of N-acetylgalactosamine syn-O-metyloxime N-[(1R,2R,3R,4R)-1-Formyl-2,4,5-trihydroxy-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-pentyl]-acetamide

N-乙酰氨基葡萄糖置于udp-Glucose 4-Epimerase,N-Acetylhexosamine 1-Kinase,Udp-Glucose-Galactose 1-Phosphate Uridylyl Transferase,5'-三磷酸腺苷,Magnesium Chloride体系中,化学反应 120.0H,反应生成N-乙酰-D-半乳糖胺
参考文献:一锅法从2-乙酰氨基-2-脱氧-D-葡萄糖(glcnac)酶法生产2-乙酰氨基-2-脱氧-D-半乳糖(galnac)
标题:一锅法从2-乙酰氨基-2-脱氧-D-葡萄糖(glcnac)酶法生产2-乙酰氨基-2-脱氧-D-半乳糖(galnac)
摘要:2-乙酰胺基-2-脱氧-D-半乳糖(galnac)是在生物功能性糖链中发现的常见单糖,但由于缺乏丰富的天然来源,其可用性通常受到限制.为了从大量可利用的糖生产galnac,使用涉及半乳糖-N-二糖/乳糖-N-的三种酶通过一锅法将2-乙酰氨基-2-脱氧-D-葡萄糖(glcnac)转化为galnac.双歧杆菌的biose I途径.以600 Mm Glcnac开始反应,在优化条件下,在催化量的atp和udp-Glc存在下,在平衡状态下产生170 Mm Galnac.使用水洗阳离子交换色谱法和常用的阳离子交换树脂将galnac与glcnac分离.
Doi:10.1016/j.Carres.2011.08.032

专利信息

专利号:US-12188072-B2
优先权日:2018-03-19
标题 :Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates
发明人：JEWETT MICHAEL CHRISTOPHER; STARK JESSICA CAROL; DELISA MATTHEW P; JAROENTOMEECHAI THAPAKORN
权利人:UNIV NORTHWESTERN; UNIV CORNELL
摘要:Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated carrier proteins. The glycosylated carrier proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated carrier proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated carrier proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.

专利号:US-12365930-B2
优先权日:2016-07-14
标题:Method for rapid in vitro synthesis of glycoproteins via recombinant production of N-glycosylated proteins in prokaryotic cell lysates
发明人：JEWETT MICHAEL CHRISTOPHER; STARK JESSICA CAROL; DELISA MATTHEW P; JAROENTOMEECHAI THAPAKORN
权利人:UNIV NORTHWESTERN; UNIV CORNELL
摘要:Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated proteins. The glycosylated proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.

专利号:US-2022395800-A1
优先权日:2019-11-04
标题:Device for automated synthesis of oligo- and polysaccharides
发明人：SEEBERGER PETER H; DANGLAD FLORES JOSE; LE MAI HOANG KIM; PARDO VARGAS ALONSO; SLETTEN ERIC; SALWICZEK MARIO
权利人:MAX PLANCK GESELLSCHAT ZU RFERDERUNG DER WSS E V; GlycoUniverse GmbH & Co KG&A
摘要:The present invention generally relates to automated synthesis technology, and more particularly, to a device and method for automated synthesis of oligo- and polysaccharides on a solid support. In particular the present invention relates to a device for automated synthesis of oligo- and polysaccharides on a solid support comprising a reaction vessel, a reagent storing component, a reagent delivery system, a cooling device for cooling reaction vessel, and a pre-cooling device for pre-cooling the reagents to be supplied.

专利号:US-2024287520-A1
优先权日:2021-06-30
标题:Method for synthesis of linkage modified oligomeric compounds
发明人：RODRIGUEZ ANDREW A
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods of synthesizing modified oligonucletodies and oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group. In certain embodiments, the present disclosure provides stabilized formulations of certain sulfonyl azides for use in the synthesis of olignonucleotides comprising one or more sulfonyl phosphoramidate linkages. Some embodiments provide stabilized compositions of high energy reagents that may be used in the synthesis of modified oligonucleotides, allowing for safe process scale preparation thereof.

专利号:WO-9423054-A1
优先权日:1993-04-05
标 题:Synthesis of tetrasaccharide
发明人：NILSSON KURT
权利人:PROCUR AB; NILSSON KURT
摘要:The present invention relates to a method for synthesis of a tetrasaccharide or a derivative thereof, which includes the initial synthesis with two different glycosidases of two disaccharides, or derivatives thereof, which after modification are used as donor and acceptor in chemical synthesis of the tetrasaccharide or its derivative.

专利号:US-10751419-B2
优先权日:2014-05-01
标题:Method for synthesis of reactive conjugate clusters
发明人：MIGAWA MICHAEL T; YU JINGHUA; WAN W BRAD; PATEL SAYTEN P; VASQUEZ GUILLERMO; KINBERGER GARTH A; PRAKASH THAZHA P; SETH PUNIT P; SWAYZE ERIC E
权利人:IONIS PHARMACEUTICALS INC
摘要:Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.