CAS: 1708-39-0; (2-Phenyl-1,3-Dioxolan-4-yl)Methanol

相似化合物

2568-25-4 936-51-6 58383-35-0

上下游产品

benzaldehyde glycerol benzaldehyde dimethyl acetal benzoyl chloride (2-phenyl-1,3-dioxolan-4-yl)methyl benzoate 2-phenyl-[1,3]dioxan-5-ol 4-(1-methoxymethyl)-2-phenyl-1,3-dioxolane palmitic acid (2-phenyl-1,3-dioxolan-4-yl)methyl ester

2-Phenyl-1,3-Dioxolane-4-Carbaldehyde置于sodium Tetrahydroborate体系中,用 乙醇,二氯甲烷 用作溶剂,化学反应 0.33H,反应生成苯甲醛甘油缩醛
参考文献:在合成类似于甘油三酯的对映纯膦酸酯中的应用:一类新的脂肪酶抑制剂
标题:在合成类似于甘油三酯的对映纯膦酸酯中的应用:一类新的脂肪酶抑制剂
摘要:膦酸酯化合物通过与催化丝氨酸形成共价键来模拟在天然底物的酶促羧酸酯水解过程中发生的第一个过渡态.然而,迄今为止,用于抑制研究的有机磷化合物或多或少类似于天然甘油三酯底物.为了阐明脂肪酶的界面活化和作用机制,需要制备特异性抑制剂.为了实现这一目标,从 C-4 手性合成子,3-丁烯-1,2-二醇开始,制备了对映体纯的 Sn-1,2-和 Sn-2,3-O-二癸酰基甘油化合物,并用 N-戊基膦酰二氯和对硝基苯酚得到相应的非对映膦酸酯,它们是酰基甘油类似物.随后分离每种膦酸酯非对映异构体 A/b 或 Ent-A/ent-B,
Doi:10.1002/(Sici)1099-0690(199907)1999:7<1671::Aid-Ejoc1671>3.0.Co;2-Z

专利信息

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.