CAS: 16079-88-2; 1-Bromo-3-Chloro-5,5-Dimethylimidazolidine-2,4-Dione

上下游产品

5,5-dimethyl-imidazolidine-2,4-dione 5,5-dimethyl-imidazolidine-2,4-dione

5,5-二甲基海因置于溴,Sodium Hydroxide,氯体系中,用 水 用作溶剂,化学反应 0.75H,以96.3%的收率获得溴氯海因
参考文献:一种溴氯海因合成过程中的尾气处理工艺
标题:一种溴氯海因合成过程中的尾气处理工艺
摘要:本发明涉及一种溴氯海因合成过程中的尾气处理工艺,其包括以下步骤,1.以5,5‑二甲基海因为原料在合成釜中制备溴氯海因;合成釜尾气通入尾气吸收釜,尾气吸收釜经环保吸收塔排空;尾气吸收釜中设置有尾气吸收液,其为5,5‑二甲基海因和氢氧化钠的水溶液或5,5‑二甲基海因和氢氧化钠的二溴海因母液的混合液;环保吸收塔中设置有淋洗吸收液,其为氢氧化钠水溶液或氢氧化钠和二溴海因母液的混合物;2.当合成釜空釜后,尾气吸收釜内的尾气吸收液转入合成釜内,环保吸收塔中内的淋洗吸收液转入尾气吸收釜中并加入5,5‑二甲基海因.本发明使溴氯海因合成过程产生的尾气,经尾气吸收釜,环保吸收塔两级吸收,达到了环保排放要求.

专利信息

专利号:WO-2013138200-A1
优先权日:2012-03-13
标 题 :Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof
发明人：FORTUNAK JOSEPH MARIAN; KULKARNI AMOL ANANT; KING CHRISTOPHER
权利人:UNIV HOWARD
摘要:Methods are provided for a green chemistry one-pot synthesis of amodiaquine and amodiaquine analogs. The methods have a lower environmental impact, lower investment cost, reduced amounts of byproducts and impurities, and a shorter synthesis time, compared to current conventional synthesis methods. The methods reduce the total number of steps in the synthesis from four to five down to two, thereby simplifying production; and allow a reduced number of solvents and reagents to be used in production, thereby reducing the waste generated in the synthesis. The methods can reduce the waste to about 3-5 kilograms of waste generated per kilogram of product produced; and surprisingly improve the overall yield from 60-65% to greater than 90% as compared to the current conventional synthesis methods for amodiaquine and its analogs.

专利号:WO-9962854-A1
优先权日:1998-06-01
标 题:Solution phase synthesis of olefins and olefin-derived products
发明人：ORGAN MICHAEL G; DIXON CRAIG E; KALDOR STEPHEN W; SIEGEL MILES G
权利人:LILLY CO ELI; ORGAN MICHAEL G; DIXON CRAIG E; KALDOR STEPHEN W; SIEGEL MILES G
摘要:This invention relates to a process for producing a plurality of olefin compounds of formula (I). The method is ideal for generating libraries of compounds for high throughput screening. The invention also provides a library of above compounds physically separated from one another in a reaction vessel. This library is useful for optimizing the activity of therapeutically useful compounds.

专利号:US-10611739-B2
优先权日:2016-08-16
标题:Process for preparation of lactone derivatives and intermediates thereof
发明人：CHEN PING; PENG SHAOPING; LI YINQIANG; LI DAFENG; DONG XUEJUN
权利人:PHARMARESOURCES SHANGHAI CO LTD
摘要:A novel process for the preparation of lactone derivatives, and intermediates thereof is described. The lactone derivatives are important precursors for the synthesis of anti-hepatitis C virus agents, including sofosbuvir.

专利号:US-5919992-A
优先权日:1996-06-11
标 题:Synthesis of haloalkynol
发明人：KUO DAVID L
权利人:LONZA AG
摘要:The present invention relates to process of halogenating an alkynol having 3 to 20 carbon atoms to produce a compound having the formula: R-C 3BOND (C-CH2)x-OH, wherein R is F, Cl, Br or I and x is 1 to 18. In particular, this invention provides a process for preparing a halopropynyl alcohol, specifically iodopropynyl alcohol. In one embodiment, iodopropynyl alcohol is produced by sequentially adding potassium hydroxide, potassium iodide and an oxidizing agent to a solution of propynyl alcohol at a rate and temperature sufficient to produce an iodopropynyl alcohol.

专利号:US-6657066-B1
优先权日:2002-12-10
标题 :Synthesis of certain triazole compounds
发明人：PLACE ILEANA; HARDER JOHN W; ROMANET ROBERT F; VREELAND WILLIAM B
权利人:EASTMAN KODAK CO
摘要:Disclosed is a process for forming a 1H-pyrazolo (1,5-b)-[1,2,4]-triazole compound by ring closing a pyrazoloamidine compound comprising reacting the amidine with an oxidizing agent having a reduction potential vs Ag/AgCl that is more positive than -0.16V and less than +1.43V in the presence of a halogen atom. The invention also discloses certain triazole compounds that are successfully made by the conventional process. The process and compounds of the invention provide improved yields and reduce or eliminate unwanted side-reactions.

专利号:US-7125906-B2
优先权日:2002-04-03
标题 :Indole derivatives having anti-angiogenetic activity
发明人：ARNOULD JEAN-CLAUDE
权利人:ASTRAZENECA AB
摘要:The invention relates to the use of a compound of Formula (I), for the manufacture of a medicament to inhibit and/or reverse and/or alleviate symptoms of angiogenesis and/or any disease state associated with angiogenesis: n nwherein: X, p, q, R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in the description. The invention also related to use of compounds of Formula (I) as medicaments and also to novel compounds of Formula (I). The invention further provides pharmaceutical compositions of compounds of Formula (I) and processes for the synthesis of compounds of Formula (I).