专利号:US-2008086013-A1 优先权日:2006-06-15 标 题:Carbometallation of alkynes and improved synthesis of uniquinones 发明人:LIPSHUTZ BRUCE H 权利人:UNIV CALIFORNIA 摘要:Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ 10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.
专利号:US-2025026768-A1 优先权日:2023-06-30 标题:Method for the synthesis of axially chiral organoboron compounds 发明人:PING YIFAN; CHE CHI-MING 权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD 摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.
专利号:US-2007260076-A1 优先权日:2003-12-05 标 题:Practical, Cost-Effective Synthesis of Ubiquinones 发明人:LIPSHUTZ BRUCE H; BERL VOLKER; SHEIN KARIN; WETTERICH FRANK 权利人:LIPSHUTZ BRUCE H; BERL VOLKER; SHEIN KARIN; WETTERICH FRANK 摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.
专利号:US-2006167289-A1 优先权日:2003-12-05 标题 :Practical, cost-effective synthesis of ubiquinones 发明人:LIPSHUTZ BRUCE H; BERL VOLKER; SCHEIN KARIN; WETTERICH FRANK 权利人:ZYMES LLC 摘要:The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.
专利号:WO-9902264-A1 优先权日:1997-07-11 标题:Membrane and method for synthesis of hydrogen peroxide 发明人:MCINTYRE JAMES A; SANDERS EDGAR S JR; MAHONEY ROBERT D; WEBB STEVEN P; MURCHISON CRAIG B; HAYES DAVID A 权利人:DOW CHEMICAL CO; MCINTYRE JAMES A; SANDERS EDGAR S JR; MAHONEY ROBERT D; WEBB STEVEN P; MURCHISON CRAIG B; HAYES DAVID A 摘要:This invention is a membrane which is useful for the synthesis of hydrogen peroxide from hydrogen and oxygen. The membrane has a hydrogen contact side and an oxygen contact side and comprises a porous hydrophobic catalyst layer facing the oxygen contact side and a gas flux control layer facing the hydrogen contact side. The gas flux control layer is positioned between the hydrogen contact side and the porous hydrophobic catalyst layer such that the flux of hydrogen may be controllably delivered to the porous hydrophobic catalyst layer. The membrane and method may be used to controllably synthesize hydrogen peroxide directly from hydrogen and oxygen without the use of organic solvents or complex equipment for ionic and electrical transport.
专利号:US-2025304580-A1 优先权日:2021-11-09 标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use 发明人:HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN 权利人:VIGIL NEUROSCIENCE INC 摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.