CAS: 13013-02-0; Methyl 4-Nitrobutyrate

相似化合物

13031-60-2 16488-43-0 75694-90-5

上下游产品

nitromethane acrylic acid methyl ester methanol Methyl 3-bromopropionate2-pyrrolidinon succinic acid 4-amino-n-butyric acid 4-nitrobutanoic acid

📜硝基甲烷,3-溴丙酸甲酯置于六甲基磷酰三胺,正丁基锂体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 25.0H,以29%的收率获得4-硝基丁酸甲酯
参考文献:Synthesis Of [3-13C]-,[4-13C]-And [11-13C]-Porphobilinogen
标题:Synthesis Of [3-13C]-,[4-13C]-And [11-13C]-Porphobilinogen
摘要:来自[1-13C]-3-(四氢吡喃-2'-基氧)-丙醛2A,甲基[4-13C]-4-硝基丁酸酯3B和[1-13C]-异氰基乙腈5C,分别合成了[4-13C]-卟胆原1A,[3-13C]-卟胆原1B和[11-13C]-卟胆原1C.构件2,3和5可以在任何同位素形式下高效制备.通过这些构件的碱催化缩合反应,可以在任何或组合的位置上丰富卟胆原的13C和15N稳定同位素.版权所有 © 2009 John Wiley & Sons,Ltd.
Doi:10.1002/jlcr.1602

专利信息

专利号:US-6515126-B2
优先权日:2000-02-28
标 题:Chemical synthesis of spirocyclic piperidines by double ring-closing metathesis
发明人：ASHWOOD MICHAEL STEWART; COTTRELL IAN FRANK; COWDEN CAMERON JOHN; WALLACE DEBRA JANE
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to a process for the preparation of a compound of formula (I) n wherein Ts is a tosylate group and R is an alkyl group, an unsubstituted phenyl or substituted phenyl ring, or a benzyl or substituted benzyl group; which comprises: n (i) cyclising a compound of formula (II) n in the presence of a suitable catalyst; and n (ii) purifying and collecting the resultant compound of formula (I).

专利号:US-8338620-B2
优先权日:2007-04-03
标 题:Methods for the production of C-8 lactam lactone compounds
发明人：SEDELMEIER GOTTFRIED
权利人:SEDELMEIER GOTTFRIED; NOVARTIS AG
摘要:The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren, the invention relates to a process for the manufacture of a compound of the formula I, n nor a salt thereof, wherein R1 as well as Act are as defined in the specification, and processes of manufacturing this compound as well as intermediates in this process.

专利号:US-2001029297-A1
优先权日:2000-02-28
标 题:Chemical synthesis of spirocyclic piperidines by double ring-closing metathesis

专利号:WO-03091210-A1
优先权日:2002-04-24
标题:A new synthesis for the preparation of porphobilinogen and the compound as such as stabilized salt and intermediates thereof
发明人：NEIER REINHARD; SOLDERMANN-PISSOT CAROLE
权利人:NEIER REINHARD; SOLDERMANN-PISSOT CAROLE
摘要:The invention relates to a new inventive process sequence of steps (a) to (e) as claimed in Claim 1 for the preparation of porphobilinogen and intermediates per se as important precursors such as 3-[4-methoxycarbonylmethyl-5-(protected amino-methyl)-1H-pyrrol-3-yl]-propionic acid methyl ester of formula 7 wherein R is phenylacetyl group, and 3-[4-Carboxymethyl-5-(protected amino-methyl)-1H-pyrrol-3-yl]-propionic acid di-alkali metal salt of formula 8 and especially 3-[4-carboxymethyl-5-(phenylacetyl-amino-methyl)-1H-pyrrol-3-yl]-propionic acid di-lithium salt of formula 8a.

专利号:US-4079076-A
优先权日:1975-04-09
标 题 :Novel cyano compounds
发明人：WEHRLI PIUS ANTON
权利人:HOFFMANN LA ROCHE
摘要:A novel conjugated diene bisfunctionalization process wherein a nitro group and a hydroxyl group in the form of an ester are introduced into the conjugated diene molecule by treatment of conjugated dienes with nitric acid in the presence of an acid anhydride. The novel compounds produced by this process and transformation products thereof, are useful as bactericides and fungicides and valuable organic synthesis intermediates, A novel procedure for the production of nitriles and γ-acetoxytiglic aldehyde is disclosed.

专利号:RU-2136675-C1
优先权日:1993-09-22
标 题 :Derivatives of 3-(5-tetrazolylbenzyl)-aminopiperidine, methods of their synthesis and pharmaceutical composition on said