(4E)-4-庚烯-2-酮置于氢溴酸,溶剂黄146体系中,化学反应生成3-庚烯-2-酮 参考文献:Pathogenicity Of Fungi Isolated From Quercus Suber In Catalonia (Ne Spain) 标题:Pathogenicity Of Fungi Isolated From Quercus Suber In Catalonia (Ne Spain) 摘要:Summary Thirty‐four Fungal Species Isolated From Cork Oak (Quercus Suber) In Catalonia (Ne Spain) During 1992-95 Were Tested For Pathogenicity Either In Stem,Leaf Or Root Inoculations. Eleven Species Were Found To Be Pathogenic On Stem: Biscogniauxia Mediterranea,Botryosphaeria Stevensii,Diatrype Cf. Stigma,Endothia Gyrosa,Fusarium Solani,Graphium Sp.,Ophiostoma Quercus,Phomopsis Sp.,Phytophthora Cinnamomi,Sporendocladia Bactrospora And An Unidentified Coelomycete. Three Fungi Showed Pathogenic Effects On Leaves: Dendrophoma Myriadea,Lembosia Quercina And Phomopsis Quercella. No Clear Pathogenic Effects Were Detected In The Root Inoculation Experiment. Trunk Pathogens Were Differentiated Into Two Groups According To The Effects Induced In The Inoculated Plants; B. Stevensii,Phomopsis Sp. And P. Cinnamomi Caused The Death Of The Inoculated Plants And Induced The Formation Of Large Cankers And Vascular Necroses. The Other Pathogenic Species Also Produced Severe Cankers And Vascular Lesions,But No Significant Mortality Was Detected. Water Stress Increased The Lesions Caused By B. Mediterranea And Phomopsis Sp.,But Limited Those Of P. Cinnamomi And The Rest Of The Inoculated Fungi. However,Water Stress Did Not Significantly Affect The Damage Caused By B. Stevensii,Which Was The Most Virulent Of The Species Tested. Leaf Pathogens Only Showed Their Effects If The Leaf Cuticle Was Previously Damaged. Lembosia Quercina Caused Small Dark Lesions Whereas D. Myriadea And P. Quercella Produced Large Necrotic Areas In Well‐watered Plants. The Lesions Caused By The Last Two Fungi Were Reduced By Water Stress. Doi:10.1046/j.1439-0329.2000.00208.X
专利号:US-10538790-B2 优先权日:2016-04-04 标题 :Bioenzymatic synthesis of THC-v, CBV and CBN and their use as therapeutic agents 发明人:KAVARANA MALCOLM J; PEET RICHARD C 权利人:TEEWINOT TECH LIMITED 摘要:The present invention provides methods for producing cannabinoids. More specifically, the invention is directed to the bio-enzymatic synthesis of THC-v, CBV and CBN by contacting a compound according to Formula I with a cannabinoid synthase enzyme. Also described is a system for producing these pharmaceutically important cannabinoids and the use of such cannabinoids as therapeutic agents.
专利号:US-10807931-B2 优先权日:2017-08-16 标 题:Synthesis of phytocannabinoids including a decarboxylation step 发明人:REEKIE TRISTAN; SCOTT MICHAEL; KASSIOU MICHAEL 权利人:UNIV SYDNEY 摘要:Method for decarboxylating a carboxylated phytocannabinoid compound of Formula I to form a phytocannabinoid compound of Formula II: Formula I Formula II wherein: R1 is selected from the group consisting of: substituted or unsubstituted C 1 -C 5 alkyl; R2 is selected from the group consisting of: OH or O, and R3 is selected from the group consisting of: a substituted or unsubstituted cyclohexene, a substituted or unsubstituted C 2 -C 8 alkene, or a substituted or unsubstituted C 2 -C 8 dialkene; or R2 is O, and R2 and R3 together form a ring structure in which R2 is an internal ring atom; wherein the method includes heating a reaction mixture comprising the carboxylated phytocannabinoid compound and a polar aprotic solvent in the presence of a LiCl for a time sufficient to decarboxylate at least a portion of the carboxylated phytocannabinoid compounds and form the phytocannabinoid compound.
专利号:US-2021163438-A1 优先权日:2017-08-16 标题 :Synthesis of phytocannabinoids including a demethylation step 发明人:REEKIE TRISTAN; SCOTT MICHAEL; KASSIOU MICHAEL 权利人:UNIV SYDNEY 摘要:A method for demethylating a methylated phytocannabinoid compound of Formula I to form a phytocannabinoid compound of Formula II: Formula I Formula II wherein: R1 is selected from the group consisting of: substituted or unsubstituted C1-C5 alkyl; R2 is selected from the group consisting of: OH or O, and R3 is selected from the group consisting of: a substituted or unsubstituted cyclohexene, a substituted or unsubstituted C2-C8 alkene, or a substituted or unsubstituted C2-C8 dialkene; or R2 is O, and R2 and R3 together form a ring structure in which R2 is an internal ring atom; wherein the method includes: heating a reaction mixture comprising the methylated phytocannabinoid compounds and a polar aprotic solvent in the presence of a dissolved inorganic alkaline salt for a time sufficient to demethylate at least a portion of the methylated phytocannabinoid compounds and form the phytocannabinoid compound.
专利号:US-9861609-B2 优先权日:2013-02-28 标题:Chemical engineering processes and apparatus for the synthesis of compounds 发明人:WINNICKI ROBERT; DONSKY MARC; SUN MINGYANG; PEET RICHARD 权利人:FULL SPECTRUM LABORATORIES LTD 摘要:The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive method is directed to contacting a compound according to Formula I or Formula II with a cannabinoid synthase. n nAlso described is a system for producing cannabinoids and cannabinoid analogs by contacting a THCA synthase with a cannabinoid precursor and modifying at least one property of the reaction mixture to influence the quantity formed of a first cannabinoid relative to the quantity formed of a second cannabinoid.
专利号:US-9102961-B2 优先权日:2009-03-11 标 题 :Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks 发明人:BAYNES BRIAN M; GEREMIA JOHN MICHAEL; LIPPOW SHAUN M 权利人:CELEXION LLC 摘要:Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane production from carbohydrates feedstocks in microorganisms. The invention also provides recombinant microorganisms and metabolic pathways for the production of difunctional alkanes.
专利号:US-2017247650-A1 优先权日:2013-02-28 标 题:Chemical engineering processes and apparatus for the synthesis of compounds
[参考文献]: K Miyashita, Et Al. Identification Of Compounds In Mouse Urine Vapor By Gas Chromatography And Mass Spectrometry. Mech Ageing Dev. 1980 Jun;13(2):177-84.
合成参考文献
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