CAS: 107818-55-3; Methyl 3-Amino-5-Bromothiophene-2-Carboxylate

相似化合物

89499-51-4 22288-78-4 946604-99-5

上下游产品

methyl 5-bromo-3-nitrothiophene-2-carboxylate 5-bromo-3-(2,2,2-trifluoracetamido)thiophene-2-carboxylic acid methyl ester Methyl 3-aminothiophene-2-carboxylate methyl 3-(2,2,2-trifluoroacetamido)thiophene-2-carboxylate 5-bromo-3-(2,2-dimethyl-[1,3]dioxan-5-ylamino)-thiophene-2-carboxylic acid methyl ester 3-amino-5-bromo-N-(4-methoxybenzyl)thiophene-2-carboxamide methyl 5-bromo-3-(4-methyl-benzylamino)-thiophene-2-carboxylate methyl 5-(4-hydroxymethylphenyl)-3-(4-methylbenzylamino)thiophene-2-carboxylate

📜5-溴-3-硝基噻吩-2-羧酸甲酯置于甲醇,Tin(Ll) Chloride体系中,化学反应 0.5H,反应生成3-氨基-5-溴噻吩-2-羧酸甲酯
参考文献:Wo2007/93365
标题:Wo2007/93365

专利信息

专利号:US-11306103-B2
优先权日:2017-11-30
标题:Thieno[3,2-b]pyridine-5(4H)-one derivative compound, preparation method thereof and use thereof
发明人：LEE JONG SEOK; SUNG DAN BI; MUN BO HYUN; LEE HYI SEUNG; LEE YEON JU; LEE JI HOON; SHIN HEE JAE; PARK SOL
权利人:KOREA INST OCEAN SCI & TECH
摘要:The present invention relates to a novel thieno[3,2-b]pyridine-5(4H)-one derivative compound, a preparation method thereof, and a use thereof. The novel thieno[3,2-b]pyridine-5(4H)-one derivative compound according to the present invention is synthesized via an aza-[3+3] cyclization addition reaction using BOP, wherein the compound is obtained by synthesizing a 4-arylthiophen-3-amine in which aryl groups such as 4-piperidyl-C6H4, 4-pyrrolidyl-C6H4, 4-MeOC6H4, 3,4,5-(MeO)3C6H4, C6H5, 4-C6H5C6H4, and 4-F3COC6H4 are introduced via a synthesis process by a bromination reaction, a hydrolysis reaction, a decarboxylation reaction, and a Suzuki coupling reaction of methyl 3-aminothiophene carboxylate, and by synthesizing 4-arylthiophen-3-amine and mono-methyl fumarate via a formal aza-[3+3] cyclization addition reaction using BOP and conjugation. Accordingly, novel thieno[3,2-b]pyridine-5(4H)-one derivative compounds according to the present invention have fluorescence properties with a wide range of emission wavelengths and thus may be utilized in various industrial fields such as physics, chemistry, and biomedical research.