CAS: 10168-00-0; 4-Bromo-5-Methylpyridine

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40899-37-4 201286-65-9 79055-50-8

上下游产品

3-Bromopyridine lithium diisopropyl amide methyl iodide 4-bromo-3-methylpyridine N-oxide 2-(3-methyl-pyridin-4-yl)-benzaldehyde 3-methyl-4-(4-(trifluoromethyl)phenyl)pyridine

3-甲基-4-硝基吡啶-N-氧化物置于三溴化磷体系中,用 乙酸乙酯 用作溶剂,化学反应 0.5H,反应生成4-溴-3-甲基吡啶
参考文献:共轭2-和4-吡啶基铜酸酯的加成:天然(-)-戊酸的快速不对称合成.
标题:共轭2-和4-吡啶基铜酸酯的加成:天然(-)-戊酸的快速不对称合成.
摘要:[反应:见正文]描绘了将2-和第一个4-吡啶基吉尔曼同价物共轭添加到各种α,β-不饱和迈克尔受体上的范围和限制.将2-溴-3-甲基吡啶的铜酸盐共轭添加到(e)-巴豆酸甲酯中,然后进行非对映选择性烯酸酯烷基化和脂肪酶介导的对映选择性酯水解,使得高效的四步第一步不对称合成celastraceae倍半萜酸酯化配体(-)-(1'S,2'S)-戊酸.
Doi:10.1021/ol070011Y

专利信息

专利号:US-8138272-B2
优先权日:2006-05-22
标 题:Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds
发明人：KONRADI ANDREI W; SMITH JENIFER L
权利人:KONRADI ANDREI W; SMITH JENIFER L; ELAN PHARM INC
摘要:This invention provides an improved synthesis of polymer conjugates of formula (I), n nof agricultural, therapeutic, and food additive compounds. In particular, a process is described for the preparation of conjugates by treating primary or secondary alcohol substituents of active compounds with polymeric nucleophiles using “Mitsunobuâ€? or related reaction conditions.

专利号:US-8921580-B2
优先权日:2012-05-09
标 题 :Methods and systems for the formation of cyclic carbonates
发明人：HATTON TREVOR ALAN; JAMISON TIMOTHY F; KOZAK JENNIFER AIDEN; SIMEON FRITZ; WU JIE
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Described herein are inventive methods for synthesis of cyclic carbonates from CO 2 and epoxide. In some embodiments, the methods are carried out in the presence of a catalyst comprising an electrophilic halogen. In some embodiments, the methods are carried out in a flow reactor.

专利号:US-2008280933-A1
优先权日:2006-07-25
标 题:Benzimidazolyl compounds
发明人：EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
权利人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2008312271-A1
优先权日:2006-07-25
标 题 :Azabenzimidazolyl compounds
发明人：EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.