CAS: 878-23-9; 2-Bromo-1-Ethylpyridin-1-Ium Tetrafluoroborate

该化合物是一种以硅化和四氟乙酸阴离子为特征的离子化合物;源自丙烯酸的酸,在2位置上具有溴基替代成分,在1位置上具有乙基组,有助于其独特特性;该化合物一般是白色到浅黄色的固体,在诸如水和酒精等极溶剂中具有溶解性;由于四氟乙酸阴离子的离子的离子性质,它经常被用作有机合成中的再试剂和相向催化剂;溴的含量增加其再活性,使其在各种化学变异中有用;此外,四氟乙基磺酰氨离子是一种稳定非核分裂的反作用,有助于稳定溶解中的碳化合物;在处理该化合物时,应采取安全防范措施,因为如果吸入或吸入,它可能会对健康构成风险.

结构式图片

相似化合物

203389-28-0 1906-79-2 2294-38-4

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

2-bromo-pyridine triethyloxonium fluoroborate tert-butyl (3R,4S,5S)-4-[(2S)-2-[[(benzyloxy)carbonyl]amino]-N,3-dimethylbutanamido]-3-methoxy-5-methylheptanoate trifluoroacetic acid

合成工艺路线路线简述

  • 合成目标产物 2-Bromo-1-Ethylpyridinium Tetrafluoroborate 主要起始原料 2-Bromopyridine And Triethyloxonium Tetrafluoroborate
  • (文献来源)合成步骤主要原料 2-Bromopyridine 和 Triethyloxonium Tetrafluoroborate

海关参考信息

专利信息


专利号:US-2010159540-A1
优先权日:2007-03-26
标题:Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
发明人:RODRIGUEZ ANA; SPUR BERND
权利人:RODRIGUEZ ANA; SPUR BERND
摘要:Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key intermediates in the preparation of such resolvins, such as isotopically labeled ω-3 fatty acid metabolites, and derivatives and analogs thereof. The invention likewise extends to the intermediates so prepared, and to the resolvins prepared with their use.

专利号:US-2008221303-A1
优先权日:2004-02-18
标 题:Method for the Preparation of Peptide-Oligonucleotide Conjugates
发明人:KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
权利人:KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI
摘要:The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人:BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:US-9938282-B2
优先权日:2014-02-05
标 题:Expedient synthesis of sitagliptin
发明人:JANAGANI SATYANARAYANA; THADURI VENKATESHWAR KUMAR; VAMARAJU RAVISANKAR
权利人:STEREOKEM INC
摘要:Novel intermediates are disclosed as intermediates for preparation of a Sitagliptin. A novel synthetic method to prepare Sitagliptin using the said intermediates is also disclosed.

专利号:US-8013117-B2
优先权日:2005-11-25
标 题 :Solution-phase synthesis of leuprolide and its intermediates
发明人:KADZIMIRSZ DANIEL; JAS GERHARD; AUTZE VOLKER
权利人:NANOKEM S A
摘要:A process for producing a nonapeptide leuprolide and an intermediate N-protected oligopetides, wherein at least one peptide bond of the compound is formed by reacting an activated carboxylic acid and an amine component in a continuous flow.

专利号:WO-2014074883-A1
优先权日:2012-11-08
标题 :Novel synthesis of ld101
发明人:THOMPSON ANDREW S; CHENG HUA
权利人:LYNDOR BIOSCIENCES L L C
摘要:Novel synthetic methods for preparation of LD101, a compound according to formula (A) are disclosed.
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主要参考文献

[参考文献]: Axel Ronald Schulz, Et Al. Low Thymic Activity And Dendritic Cell Numbers Are Associated With The Immune Response To Primary Viral Infection In Elderly Humans. J Immunol. 2015 Nov 15;195(10):4699-711.
[参考文献]: Changqing Zhang, Et Al. Beta-Endorphin Cell Therapy For Cancer Prevention. Cancer Prev Res (Phila). 2015 Jan;8(1):56-67.
[参考文献]: Daniel Bertin, Et Al. Diagnostic Performance Of A New Vimentin-Derived Acpa (Ccp High Sensitive) In Patients With Rheumatoid Arthritis. Immunol Res. 2016 Apr;64(2):455-60.
[参考文献]: Elaine B Sinclair, Et Al. Differential Mesocorticolimbic Responses To Palatable Food In Binge Eating Prone And Binge Eating Resistant Female Rats. Physiol Behav. 2015 Dec 1;152(Pt A):249-56.
[参考文献]: Lingqian Chang, Et Al. Dielectrophoresis-Assisted 3D Nanoelectroporation For Non-Viral Cell Transfection In Adoptive Immunotherapy. Lab Chip. 2015 Aug 7;15(15):3147-53.

合成参考文献


参考文献:10.1007/s00044-023-03066-2
摘要:Kuhn B, Ritter M, Benz J, Kocer B, Sarie JC, Hochstrasser R, Rudolph MG, Kadono S, Matsuura T, Murata T, Richter H, Prunotto M. Novel potent and highly selective DDR1 inhibitors from integrated lead finding. Med Chem Res. 2023 May 15;32(7):1400–25. doi: 10.1007/s00044-023-03066-2.
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