专利号:US-2010159540-A1 优先权日:2007-03-26 标题:Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof 发明人:RODRIGUEZ ANA; SPUR BERND 权利人:RODRIGUEZ ANA; SPUR BERND 摘要:Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key intermediates in the preparation of such resolvins, such as isotopically labeled ω-3 fatty acid metabolites, and derivatives and analogs thereof. The invention likewise extends to the intermediates so prepared, and to the resolvins prepared with their use.
专利号:US-2008221303-A1 优先权日:2004-02-18 标 题:Method for the Preparation of Peptide-Oligonucleotide Conjugates 发明人:KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI 权利人:KATZHENDLER JEHOSHUA; KLAUZNER YAKIR; BEYLIS IRENA; MIZHIRITSKII MICHAEL; SHPERNAT YAACOV; ASHKENAZI BORIS; FRIDLAND DMITRI 摘要:The present invention relates to the synthesis of peptide-oligonucleotide conjugates (POC). More specifically, the invention relates to a novel method for the preparation of peptide-oligonucleotide conjugates, which can be conducted under mild conditions on solid support, can be performed manually or by a synthesizer, can be used to synthesize alternating sequences of peptides and oligonucleotides, and is applicable to the synthesis of a wide variety of peptide-oligonucleotide conjugates constructed from alternate peptide and oligonucleotide blocks.
专利号:US-2022233673-A1 优先权日:2019-06-04 标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF 发明人:BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M 权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND 摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.
专利号:US-9938282-B2 优先权日:2014-02-05 标 题:Expedient synthesis of sitagliptin 发明人:JANAGANI SATYANARAYANA; THADURI VENKATESHWAR KUMAR; VAMARAJU RAVISANKAR 权利人:STEREOKEM INC 摘要:Novel intermediates are disclosed as intermediates for preparation of a Sitagliptin. A novel synthetic method to prepare Sitagliptin using the said intermediates is also disclosed.
专利号:US-8013117-B2 优先权日:2005-11-25 标 题 :Solution-phase synthesis of leuprolide and its intermediates 发明人:KADZIMIRSZ DANIEL; JAS GERHARD; AUTZE VOLKER 权利人:NANOKEM S A 摘要:A process for producing a nonapeptide leuprolide and an intermediate N-protected oligopetides, wherein at least one peptide bond of the compound is formed by reacting an activated carboxylic acid and an amine component in a continuous flow.
专利号:WO-2014074883-A1 优先权日:2012-11-08 标题 :Novel synthesis of ld101 发明人:THOMPSON ANDREW S; CHENG HUA 权利人:LYNDOR BIOSCIENCES L L C 摘要:Novel synthetic methods for preparation of LD101, a compound according to formula (A) are disclosed.
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合成参考文献
参考文献:10.1007/s00044-023-03066-2 摘要:Kuhn B, Ritter M, Benz J, Kocer B, Sarie JC, Hochstrasser R, Rudolph MG, Kadono S, Matsuura T, Murata T, Richter H, Prunotto M. Novel potent and highly selective DDR1 inhibitors from integrated lead finding. Med Chem Res. 2023 May 15;32(7):1400–25. doi: 10.1007/s00044-023-03066-2.