CAS: 86069-86-5; (S)-1-(((9H-Fluoren-9-yl)Methoxy)Carbonyl)Piperidine-2-Carboxylic Acid

该化合物是一种多用途的氨基酸衍生物,提供了方便的处理和净化过程,其氢氧基功能可以方便地进行修改和同化,使之适合各种合成应用.Fmoc小组促进高效的固相化物合成,而氢氧基组则为进一步的化学变异提供了灵活性.该化合物是研究者在peptide合成和药物发现中寻找可靠构件的理想化合物.

结构式图片

相似化合物

105751-19-7 101555-63-9 1723-00-8

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

(fluorenylmethoxy)carbonyl chloride (2S)-2-piperidinecarboxylic acid L-tartrate (9-fluorenyl)methyl pentafluorophenyl carbonate pipecolinic acidFm°C-Pip-Pfp (S)-1-(9H-fluoren-9-yl)methyl 2-((R)-1-(3-(2-tert-butoxy-2-oxo-ethoxy) phenyl)-3-(3,4-dimethoxyphenyl)propyl) piperidine-1,2-dicarboxylate Z-Aib-Aib-Pip-Aib-Gly-OH (S)-piperidine-1,2-dicarboxylic acid 2-[(R)-1-[3-(tert-butyl-dimethyl-silanoxy)-phenyl]-3-(3,4-dimethoxy-phenyl)-propyl] ester 1-(9H-fluoren-9-yl)methyl ester

合成工艺路线路线简述

  • 28920-43-6 + 3105-95-1 = 86069-86-5 [标题:Reaction Conditions
    标题:Use Of N-Fmoc Amino Acid Chlorides And Activated 2-(Fluorenylmethoxy)-5(4H)-Oxazolones In Solid-Phase Peptide Synthesis. Efficient Syntheses Of Highly N-Alkylated Cyclic Hexapeptide Oxytocin Antagonists Related To L-365,209
    作者:Perlow,Debra S.; Erb,Jill M.; Gould,Norman P.; Tung,Roger D.; Freidinger,Roger M.; Et Al
    参考文献:Journal Of Organic Chemistry 日期:1992 卷标:57(16) 页码:4394-400]

    28920-43-6 + 3105-95-1 = 86069-86-5
    反应条件:1.1 Reagents: Chlorotrimethylsilane,Diisopropylethylamine Solvents: Dichloromethane1.2 -
    标题:Synthesis And Fkbp Binding Of Small Molecule Mimics Of The Tricarbonyl Region Of Fk506
    作者:Wang,Gary T.; Lane,Ben; Fesik,Stephen W.; Petros,Andrew; Luly,Jay; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:1994 卷标:4(9) 页码:1161-6]

    82911-69-1 + 3105-95-1 = 86069-86-5
    反应条件:1.1 Reagents: Sodium Carbonate Solvents: Dimethylformamide,Water; 10 Min,0 °C; 0 °C -> Rt; 1.5 H,Rt
    标题:Synthesis Of Bioactive 2-Aza-Analogues Of Ipecac And Alangium Alkaloids
    作者:Koelzer,Michael; Weitzel,Kerstin; Goeringer,H. Ulrich; Thines,Eckhard; Opatz,Till
    参考文献:Chemmedchem 日期:2010 卷标:5(9) 页码:1456-1464]

    28920-43-6 + 3105-95-1 = 86069-86-5
    反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Water; Rt1.2 Solvents: Acetone; 18 H,Rt
    标题:Synthesis Of Shld Derivatives,Their Binding To The Destabilizing Domain,And Influence On Protein Accumulation In Transgenic Plants
    作者:Joergensen,Frederik Praestholm; Madsen,Daniel; Meldal,Morten; Olsen,Jacob Valdbjoern; Petersen,Morten; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2019 卷标:62(10) 页码:5191-5216]

    82911-69-1 + 3105-95-1 = 86069-86-5
    反应条件:1.1 Reagents: Sodium Carbonate Solvents: Water; 5 Min,Rt1.2 Solvents: 1,4-Dioxane; 24 H,Rt1.3 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
    标题:Evaluation Of Synthetic Fk506 Analogues As Ligands For The Fk506-Binding Proteins 51 And 52
    作者:Gopalakrishnan,Ranganath; Kozany,Christian; Gaali,Steffen; Kress,Christoph; Hoogeland,Bastiaan; Et Al
    参考文献:Journal Of Medicinal Chemistry 日期:2012 卷标:55(9) 页码:4114-4122]

    28920-43-6 + 3105-95-1 = 86069-86-5
    反应条件:1.1 Reagents: Sodium Carbonate Solvents: 1,4-Dioxane,Water; 16 H,Rt
    标题:Heterocyclic Core Analogs Of A Direct Thrombin Inhibitor
    作者:Blizzard,Timothy A.; Singh,Sanjay; Patil,Basanagoud; Chidurala,Naresh; Komanduri,Venukrishnan; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2014 卷标:24(4) 页码:1111-1115]

    105751-19-7 = 86069-86-5 + 101555-63-9
    反应条件:1.1 Reagents: 1,1-Dimethylethyl N-[(1R)-2-[[(8α,9S)-6′-Methoxycinchonan-9-Yl]Amino]-1-(1-Methy... (Reaction Products With Mercaptopropyl Silica Gel)
    标题:Chromatographic Enantiomer Separation Using 9-Amino-9-(Deoxy)-Epiquinine-Derived Chiral Selectors: Control Of Chiral Recognition Via Introduction Of Additional Stereogenic Centers
    作者:Maier,Norbert M.; Greco,Elisa; Petrovaj,Jan; Lindner,Wolfgang
    参考文献:Acta Chimica Slovenica 日期:2012 卷标:59(3) 页码:454-463
📜六氢吡啶-Alpha-羧酸 反应生成 (2R)-1-[(9H-芴-9-甲氧基)羰基]哌啶-2-甲酸
参考文献:抗真菌二肽petriellin A的全合成
标题:抗真菌二肽petriellin A的全合成
摘要:我们报告了抗真菌的高度修饰的环状depsipeptide Petriellin A的固相全合成.该合成证实了关于天然产物的绝对构型的早期报道.固相方法得到受保护的线性前体,其在环化和最终脱保护之前从固体支持物上裂解下来.先进的偶联剂用于几种受阻酰胺是合成的一个特征.天然产物的总产率为5%.
DOI:10.1021/jo201017W

海关参考信息

专利信息


专利号:US-2018147294-A1
优先权日:2013-06-06
标 题:Antibody-drug conjugates, compositions and methods of use
发明人：JACKSON DAVID Y; HA EDWARD; PROBST GARY D
权利人:JACKSON DAVID Y; HA EDWARD; PROBST GARY D
摘要:Antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, tubulysin analogs, and intermediates in their synthesis; compositions; and methods, including methods of treating cancers.

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:US-2020392108-A1
优先权日:2011-12-05
标题:Antibody-drug conjugates and related compounds, compositions and methods
发明人：JACKSON DAVID Y; HA EDWARD
权利人:MAGENTA THERAPEUTICS INC
摘要:Antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, tubulysin analogs, and intermediates in their synthesis; compositions; and methods, including methods of treating cancers.

专利号:CN-118878622-A
优先权日:2024-09-27
标 题:Green chemical synthesis method of illegal stand

专利号:CN-117143179-A
优先权日:2023-09-18
标题 :A synthesis method of thrombin chromogenic substrate S-2238

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主要参考文献

参考标题:A Lanthanide(III) Triflate Mediated Macrolactonization/solid-Phase Synthesis Approach For Depsipeptide Synthesis
作者:Jordan D. Goodreid,Eduardo Da Silveira Dos Santos,Robert A. Batey |发布日期:2015.5.1
摘要:The Effect Of Dysprosium(III) Triflate On Macrolactonization Reactions To Form Depsipeptides Using Mnba (Shiina'S Reagent) Is Reported. Improved Yields Were Obtained For The Formation Of 16-Membered Depsipeptides Using Lanthanide Triflate Additives. The Use Of A Macrocyclization Strategy Permits The Use Of A Semiautomated Solid-Phase Synthesis Approach For The Rapid Synthesis Of Analogues Of The Antibacterial

合成参考文献


参考文献:10.1016/j.antiviral.2011.06.006
摘要:Campagnola G, Gong P, Peersen OB. High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. Antiviral Research. 2011 Sep;91(3):241–51. doi: 10.1016/j.antiviral.2011.06.006.
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