CAS: 845306-08-3; Tert-Butyl 5-Bromopicolinate

该化合物是有机合成中的一种多用途中间体,特别是其溴和酯功能组群的价值.乙型-丁基乙酸酯会增强稳定,便于在温和酸性条件下有选择地取消保护,使其适合渐进合成战略.五点的溴替代体通过交叉反应,如铃木或尼吉什交配,可以进一步功能化,从而能够制造复杂的衍生物.该化合物通常用于用于发展七环型的制药和农用化学研究,其高纯度和定义明确的再活动特征使其成为目标分子合成的可靠建筑块.

结构式图片

相似化合物

30766-11-1 2404734-24-1 1289210-83-8

物理性质

MSDS等安全信息

欧盟法规

C&L通报

上下游产品

CAS号30766-11-1 5-溴-2-羧基吡啶 | CAS号75-65-0 叔丁醇 | CAS号29682-15-3 5-溴吡啶-2-羧酸甲酯 | CAS号30766-11-1 5-溴-2-羧基吡啶 | CAS号1354356-24-3 5-(4,4,5,5-四甲基-... | CAS号1214339-84-0 [3,3'-联吡啶]-6-羧酸

合成工艺路线路线简述

  • 29682-15-3 = 845306-08-3
    反应条件:1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran,Hexane; 0 °C; 10 Min,0 °C1.2 Solvents: Tetrahydrofuran; 1 H,0 °C
    标题:Direct C-2 Arylation Of Alkyl 4-Thiazolecarboxylates: New Insights In Synthesis Of Heterocyclic Core Of Thiopeptide Antibiotics
    作者:Martin,Thibaut; Et Al
    参考文献:Organic Letters 日期:2008 卷标:10(13) 页码:2909-2912]

    24424-99-5 + 30766-11-1 = 845306-08-3
    反应条件:1.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Toluene; 0 °C; 20 H,50 °C
    标题:Total Synthesis Of Micrococcin P1 And Thiocillin I Enabled By Mo(Vi) Catalyst
    作者:Akasapu,Siddhartha; Et Al
    参考文献:Chemical Science 日期:2019 卷标:10(7) 页码:1971-1975
📜5-溴-2-吡啶羧酸置于4-二甲氨基吡啶体系中,用 叔丁醇 作为反应溶剂,化学反应生成 5-溴吡啶甲酸叔丁酯
参考文献:Androgen Receptor Modulating Carboxamides
标题:Androgen Receptor Modulating Carboxamides
摘要:式(I)或(II)的化合物 其中r X,R Z,R 9,R 10,R 14,R 14 ',R 15,R 15 ',A和b如权利要求中所定义,并且其药学上可接受的盐和酯已被披露.这些化合物具有作为组织选择性雄激素受体调节剂(sarm)的效用,并且在治疗前列腺癌和其他依赖于ar的疾病和病症中,需要ar拮抗作用时可用作药物.

海关参考信息

专利信息


专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:US-9744173-B2
优先权日:2014-04-10
标题 :2-amino 6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,3-thiazol-4-yl amides
发明人：BRODNEY MICHAEL AARON; BECK ELIZABETH MARY; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; BARREIRO GABRIELA; LACHAPELLE ERIK ALPHIE; ROGERS BRUCE NELSEN
权利人:PFIZER
摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variable R 1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

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合成参考文献

合成方法参考DOI号:10.1021/ol801035c
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