CAS: 825-44-5; Benzothiophene 1,1-Dioxide
该化合物是一种杂交循环化合物,其特点是一个有引信的苯和硫苯环系统,其两个氧原子双倍地附着在硫磺中心.这一结构具有独特的电子和化学特性,在有机合成和材料科学中具有价值.其高度稳定性和电子提取性有利于在药品,农用化学品和光电子材料中的应用.该化合物是合成含有全氟辛烷磺酸的衍生物的关键中间体,经常用于药物发现和功能材料中.其定义明确的再活性和与各种反应条件的兼容性增强了其在复杂的分子变异中的效用.
- 英文名称Benzothiophene 1,1-Dioxide
- 中文名称苯并[b]噻吩1,1-二氧化物
- IUPAC名称benzo[b]thiophene 1,1-dioxide
- 其它别名Benzothiophene 1,1-dioxide; BENZO[B]THIOPHENE 1,1-DIOXIDE; 1-BENZOTHIOPHENE 1,1-DIOXIDE; 1H-1LAMBDA6-BENZO[B]THIOPHENE-1,1-DIONE; THIANAPHTHENE-1,1-DIOXIDE; Benzobüthiophene 1,1-dioxide, ; Thianaphthene-1,1-dioxide,
- CAS编号825-44-5
- MFCD编号:MFCD00052178
- EINECS号:212-544-8
- FDA UNII编号:JHF9X2MG7W
- 分子式:C8H6O2S
- 分子量:166.2
- 产品CID: 1816002
- 产品分类有机原料→分子砌块→芳杂环类化合物→苯并噻吩类化合物
- 相似结构搜索
- 产品信息参考
; - InChIKey: FRJNKYGTHPUSJR-UHFFFAOYSA-N
- InChI=1S/C8H6O2S/c9-11(10)6-5-7-3-1-2-4-8(7)11/h1-6H…
- 计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数0.0
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报REACH预注册上下游产品
CAS号95-15-8 苯并噻吩 | CAS号7722-84-1 过氧化氢 | CAS号64-19-7 冰醋酸 | CAS号14315-13-0 2,3-二氢苯并[b]噻吩1,... | CAS号20503-40-6 6-氨基苯并噻吩-1,1-二氧烷 | CAS号95-15-8 苯并噻吩 | CAS号20841-53-6 naphtho[2,1-b][... | CAS号86043-93-8 benzo(kl)thioxa... | CAS号205-43-6 苯并[b]萘[1,2-d]噻吩 | CAS号1022-19-1 Piperidine, 1-(... | CAS号10133-41-2 2-chloro-1-benz... | CAS号33524-67-3 3,4,5,6-Tetraph...合成工艺路线路线简述
- 95-15-8 = 825-44-5
反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: (Pb-7-23-111′1′2)-Diaquaoxodiperoxymolybdenum Solvents: Water,1-Butyl-3-Methylimidazolium Hexafluorophosphate; 18 H,60 °C
标题:Experimental And Theoretical Insights Into The Oxodiperoxomolybdenum-Catalysed Sulphide Oxidation Using Hydrogen Peroxide In Ionic Liquids
作者:Carrasco,Carlos J.; Et Al
参考文献:Dalton Transactions 日期:2014 卷标:43(36) 页码:13711-13730]
95-15-8 = 825-44-5
反应条件:1.1 Catalysts: 1-Octadecanaminium,N,N-Dimethyl-N-Octadecyl-,[μ6-[orthoperiodato(5-)-Ko,Ko′:Ko... Solvents: Decalin; 5 Min,100 °C1.2 Reagents: Oxygen; 2.5 H,1 Atm,100 °C
标题:Aerobic Oxidative Desulfurization Of Benzothiophene,Dibenzothiophene And 4,6-Dimethyldibenzothiophene Using An Anderson-Type Catalyst [(C18H37)2N(Ch3)2]5[imo6O24]
作者:Lue,Hongying; Et Al
参考文献:Green Chemistry 日期:2010 卷标:12(11) 页码:1954-1958]
95-15-8 = 825-44-5 + 51500-42-6
反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide Catalysts: 1584692-48-7 Solvents: 1,2-Dichloroethane; 30 H,Reflux
标题:Oxidation Of Alkenes And Sulfides Catalyzed By A New Binuclear Molybdenum Bis-Oxazoline Complex
作者:Moshref Javadi,Maedeh; Et Al
参考文献:Polyhedron 日期:2014 卷标:72 页码:19-26]
132-65-0 = 825-44-5 + 51500-42-6
反应条件:1.1 Reagents: Iodosylbenzene Catalysts: Iron Tetraphenylporphyrin Chloride Solvents: Methanol; > 5 Min,Rt
标题:Evidence Of Two Key Intermediates Contributing To The Selectivity Of P450-Biomimetic Oxidation Of Sulfides To Sulfoxides And Sulfones
作者:Zhou,Xinrui; Et Al
参考文献:Chemistry - An Asian Journal 日期:2012 卷标:7(10) 页码:2253-2257]
95-15-8 + 132-65-0 = 825-44-5 + 1016-05-3
反应条件:1.1 Catalysts: Iron Oxide (Fe3O4),Silica,Silicomolybdic Acid,Polythiophene Solvents: Hexane; 60 Min,40 °C1.2 Reagents: Hydrogen Peroxide; 40 °C
标题:Catalytic/photocatalytic Oxidative Desulfurization Activities Of Heteropolyacid Immobilized On Magnetic Polythiophene Nanocatalyst
作者:Shafi,Ruaa Fadhil; Et Al
参考文献:Journal Of Sulfur Chemistry 日期:2021 卷标:42(4) 页码:443-463]
51500-42-6 = 825-44-5
反应条件:1.1 Reagents: Iodosylbenzene Catalysts: Iron Tetraphenylporphyrin Chloride Solvents: Methanol; > 5 Min,Rt
标题:Evidence Of Two Key Intermediates Contributing To The Selectivity Of P450-Biomimetic Oxidation Of Sulfides To Sulfoxides And Sulfones
作者:Zhou,Xinrui; Et Al
参考文献:Chemistry - An Asian Journal 日期:2012 卷标:7(10) 页码:2253-2257]
95-15-8 = 825-44-5
反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: 2066474-71-1 Solvents: Ethyl Acetate,Water; 2 H,343 K
标题:A New Halide-Free Efficient Reaction-Controlled Phase-Transfer Catalyst Based On Silicotungstate Of [(C18H37)2(Ch3)2N]3[sio4H(Wo5)3] For Olefin Epoxidation,Oxidation Of Sulfides And Alcohols With Hydrogen Peroxide
作者:Ma,Baochun; Et Al
参考文献:Rsc Advances 日期:2014 卷标:4(61) 页码:32054-32062]
132-65-0 = 825-44-5
反应条件:1.1 Reagents: Iodosylbenzene Catalysts: Iron Tetraphenylporphyrin Chloride Solvents: Methanol; > 5 Min,Rt2.1 Reagents: Iodosylbenzene Catalysts: Iron Tetraphenylporphyrin Chloride Solvents: Methanol; > 5 Min,Rt
标题:Evidence Of Two Key Intermediates Contributing To The Selectivity Of P450-Biomimetic Oxidation Of Sulfides To Sulfoxides And Sulfones
作者:Zhou,Xinrui; Et Al
参考文献:Chemistry - An Asian Journal 日期:2012 卷标:7(10) 页码:2253-2257]
95-15-8 = 825-44-5 + 51500-42-6
反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: 1542160-51-9 Solvents: Acetonitrile,Water; 3 H,45 °C1.2 Reagents: Manganese Oxide (Mno2); 10 Min
标题:Niobium(V) Oxido Tris-Carbamate As Easily Available And Robust Catalytic Precursor For The Selective Sulfide To Sulfone Oxidation
作者:Bresciani,Giulio; Et Al
参考文献:Molecular Catalysis 日期:2021 卷标:516]
95-15-8 = 825-44-5 + 51500-42-6
反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: 1641528-60-0 Solvents: Ethanol; 60 Min,Reflux
标题:Epoxidation Of Alkenes And Oxidation Of Sulfides Catalyzed By A New Binuclear Vanadium Bis-Oxazoline Complex
作者:Javadi,Maedeh Moshref; Et Al
参考文献:Journal Of The Iranian Chemical Society 日期:2015 卷标:12(3) 页码:477-485]
95-15-8 + 1207-12-1 + 132-65-0 = 825-44-5 + 1016-05-3 + 2657-73-0 + 6909-77-9
反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Zirconium Dioxide,Tungsten Oxide (Wo3) Solvents: Heptane,Water; 60 Min,333 K
标题:Oxidative Desulfurization (Ods) Of Organosulfur Compounds Catalyzed By Peroxo-Metallate Complexes Of Wox-Zro2 And Thermochemical,Structural,And Reactivity Indexes Analyses
作者:Torres-Garcia,E.; Et Al
参考文献:Journal Of Catalysis 日期:2011 卷标:282(1) 页码:201-208]
95-15-8 = 825-44-5 + 121823-03-8 + 205-43-6
反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Solvents: Dichloromethane; 0 °C; Overnight,Rt
标题:Bacterial Dioxygenase- And Monooxygenase-Catalysed Sulfoxidation Of Benzo[b]Thiophenes
作者:Boyd,Derek R.; Et Al
参考文献:Organic & Biomolecular Chemistry 日期:2012 卷标:10(4) 页码:782-790
苯并噻吩置于氧气体系中,用 萘烷 作为反应溶剂,80.0 °C,101.33 Kpa 条件下,反应生成 苯并噻吩砜
参考文献:Aerobic Oxidative Desulfurization Of Benzothiophene,Dibenzothiophene And 4,6-Dimethyldibenzothiophene Using An Anderson-Type Catalyst [(C18H37)2N(Ch3)2]5[imo6O24]
标题:Aerobic Oxidative Desulfurization Of Benzothiophene,Dibenzothiophene And 4,6-Dimethyldibenzothiophene Using An Anderson-Type Catalyst [(C18H37)2N(Ch3)2]5[imo6O24]
摘要:苯并噻吩 (Bt),二苯并噻吩 (Dbt) 和 4,6-二甲基二苯并噻吩 (4,6-Dmdbt)置于anderson 型催化剂 [(C18H37)2N(Ch3)2]5Imo6O24 的作用下,以分子氧为原料,氧化成相应的砜.反应条件温和,为氧化剂.这些难熔的含硫化合物可以在没有任何牺牲剂的情况下被完全氧化.乙腈,水等溶剂对氧化脱硫系统产生负面影响.两亲性安德森催化剂的催化活性取决于季铵阳离子.含硫化合物的反应活性顺序为4,6-Dmdbt > Dbt > Bt.
DOI:10.1039/c0Gc00271B
海关参考信息
- 2901210000-乙烯
2902300000-甲苯
2902500000-苯乙烯
2930909099-其他有机硫化合物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8183294-B2
优先权日:2005-03-14
标 题 :Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
发明人：LOUVET PHILIPPE; SCHWEIZER DOMINIQUE
权利人:LOUVET PHILIPPE; SCHWEIZER DOMINIQUE; Cephelon France
摘要:The invention relates to a method for preparing a sulphoxide compound of formula (I) either as a single enantiomer or in an enantiomerically enriched form, comprising the steps of:n a) contacting a pro-chiral sulphide of formula (II) with a metal chiral complex, a base and an oxidizing agent in an organic solvent; and optionally b) isolating the obtained sulphoxide of formula (I). nn nwherein Ar, Y, R 1 are as defined in claim 1.
专利号:US-7365197-B2
优先权日:2000-12-29
标题 :Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines
发明人：BERGER DAN MAARTEN; BIRNBERG GARY HAROLD; WANG YANONG
权利人:WYETH CORP
摘要:This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.
专利号:EP-1863760-B1
优先权日:2005-03-14
标 题 :Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.
专利号:US-2006205706-A1
优先权日:2005-03-14
标 题:Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
专利号:WO-2025078040-A1
优先权日:2023-10-09
标 题 :Lysine salt and method of manufacturing a lysine derivative
发明人：HINTERMANN TOBIAS; SCHWINDLING JOACHIM; RÃœEFLI PASCAL; SCHÖNLEBER RALPH O; WILLIG FELIX; MELZIG LAURIN; ERMERT PHILIPP; KÃœMIN MICHAEL; SCHWIZER NATASCHA; SCHNEIDER ANGELIKA; SCHMID LUCIUS
权利人:BACHEM HOLDING AG
摘要:The invention relates to a Bsmoc-protected lysine salt of formula (1 X ), e.g., a hydrochloric acid salt (n = 1, HY = hydrochloric acid). It further relates to a method of manufacturing Bsmoc-protected lysine derivatives, which employs the Bsmoc-protected lysine salt of formula (1 X ) and comprises the step of reacting the epsilon amino group of lysine with an 10 activated carboxylic acid derivative. Some of the obtainable Bsmoc-protected lysine derivatives with their side chain modification are useful as starting materials in solid phase peptide synthesis.
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合成参考文献
参考文献:10.1023/b:jobb.0000019601.74394.67
摘要:Pereira MM, Bandeiras TM, Fernandes AS, Lemos RS, Melo AMP, Teixeira M. Respiratory Chains from Aerobic Thermophilic Prokaryotes. Journal of Bioenergetics and Biomembranes. 2004 Feb;36(1):93–105. doi: 10.1023/b:jobb.0000019601.74394.67.
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