CAS: 75-36-5; Acetyl Chloride

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阿司匹林置于五氯化铌体系中,用 二氯甲烷-D2 作为反应溶剂,化学反应 30.0H,反应生成 乙酰氯
参考文献:Synthesis And Spectroscopic/dft Structural Characterization Of Coordination Compounds Of Nb(V) And Ti(Iv) With Bioactive Carboxylic Acids
标题:Synthesis And Spectroscopic/dft Structural Characterization Of Coordination Compounds Of Nb(V) And Ti(Iv) With Bioactive Carboxylic Acids
摘要:The Reactions Are Reported Of Nbx5 (X = Cl,Br),Ticl4 And Ti((Opr)-Pr-I)(4) With A Selection Of Carboxylic Acids Exhibiting A Known Biological Role,In A Chlorinated Solvent. The Reactions Of Nbx5 With Acetylsalicylic Acid (Aspirin) Proceeded With Selective Deacetylation Of The Organic Reactant And Formation Of The Salicylate Complexes Nbx4(C7H5O3) (1A,X = Cl; 1B,X = Br) In 60-65% Yields. Nbcl5 Reacted With Diclofenac And Ethacrynic Acid (Ea-Co2H) To Give Nbcl3[kappa(3)(O,O,N)-O2Cch2(C6H4)Nc6H3Cl2],2 (80% Yield),And Nbcl4(O2C-Ea),3 (72% Yield),Respectively. Ti((Opr)-Pr-I)(4) Reacted With Ethacrynic Acid Giving Ti((Opr)-Pr-I)(2)(O2C-Ea)(2),4,In 74% Yield,As A Mixture Of Two Isomers. All The Products Were Characterized By Means Of Analytical And Spectroscopic Methods,Moreover Dft Studies Were Carried Out To Give Insight Into Structural Features. (C) 2017 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Poly.2017.11.042

专利信息

专利号:US-6515039-B1
优先权日:1998-08-28
标 题:Method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material
发明人：ULBRICHT MATHIAS; VOLKMER-ENGERT RUDOLF; GERMEROTH LOTHAR; WENSCHUH HOLGER
权利人:POLY AN GMBH
摘要:The invention relates to a method for the parallel and combinatory synthesis of compounds bound to a continuous polymeric solid phase supporting material. According to the method, a continuous polymeric solid phase supporting material is prepared, the material comprising a matrix of a supporting polymeric material and graft copolymer chains covalently bound to the supporting matrix, the graft copolymer chains having reactive groups being able to react with organic compounds, thereby forming spatially defined reaction sites. The method then comprises the sequential spotting of synthesis building blocks or reagents at the various reaction sites on the continuous solid phase supporting material to yield a substrate library of compounds bound to the solid phase supporting material, whereby each reaction site on the continuous solid phase supporting material determines the composition of the synthesized compound, which is bound directly on the supporting matrix via the reactive groups of the graft polymer chain.

专利号:US-8748660-B2
优先权日:2012-07-09
标题:Process for the synthesis of antiepileptic drug lacosamide
发明人：MURUGAN MUTHUKRISHNAN; MUJAHID MOHAMMAD; MAJUMDAR PRASHANT PRAMOD
权利人:MURUGAN MUTHUKRISHNAN; MUJAHID MOHAMMAD; MAJUMDAR PRASHANT PRAMOD; COUNCIL SCIENT IND RES
摘要:The present invention relates to the improved and efficient process for the synthesis of antiepileptic drug Lacosamide in high enantiopurity (>98% ee) and better yield. More particularly, the present invention relates to improved and efficient, cost effective process for synthesis of desired (R) isomer of Lacosamide starting from commercially available (S)-benzyl glycidyl ether.

专利号:WO-2024084491-A1
优先权日:2022-10-21
标题:Process for synthesis of res metirom and its intermediates thereof
发明人：MEHTA NILESH VIPINCHANDRA
权利人:MEHTA NILESH VIPINCHANDRA
摘要:The present invention discloses a process for synthesis of Res metirom and its intermediates thereof. More particularly, the invention discloses process for synthesis of a key intermediate, 6-(4-amino, 2,6-dichlorophenoxy)4- isopropylpyridazin-3(2H)-one, of Res metirom via novel intermediate compounds of formula A. Wherein, R is selected from methyl, ethyl and propyl.

专利号:WO-2024105700-A1
优先权日:2022-11-18
标 题:A method for the synthesis of anthranilic amide compounds and intermediates thereof
发明人：MALVIYA NITIN; MAL SANJIB; KLAUSENER ALEXANDER G M
权利人:PI INDUSTRIES LTD
摘要:The present invention discloses a method for the synthesis of a compound of formula (V) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The method further comprises the synthesis of an anthranilic diamide compound of formula (Z).

专利号:US-12240808-B2
优先权日:2021-05-28
标 题 :Process for the synthesis of calebin-a and its intermediates
发明人：MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; NAIDU PENTAKOTA PARADESI
权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; NAIDU PENTAKOTA PARADESI
摘要:The invention discloses novel intermediates in the synthesis of Calebin A represented by formula 3. The invention also covers processes for the synthesis of Calebin-A and its analogs using compounds of formula 3.

专利号:WO-2024036115-A1
优先权日:2022-08-08
标题:Continuous flow synthesis of lorazepam
发明人：THOMPSON DAVID; BIYANI SHRUTI; HYUN SEOK-HEE; MCGUIRE MICHAEL
权利人:PURDUE RESEARCH FOUNDATION; CONTINUITY PHARMA LLC
摘要:A method for synthesis of Lorazepam in a continuous flow using continuous flow reactor, in which method comprises five steps including N-acylation, diazepine ring closure, imine N- oxidation, Polonovski-type rearrangement, and ester hydrolysis; a green reagent comprising a peroxide reagent and rhenium oxide catalyst for N-oxidation of delorazepam; and an ammonium source combination for the synthesis of delorazepam.