CAS: 698-30-6; 5-(Hydroxymethyl)-2-Methylpyrimidin-4(1H)-One
该化合物是具有湿米丁环结构,这是一个六人环,含有位于1和3号位置的两个氮原子. 该化合物的特点是5号位置的氢氧基甲基组(-CH2OH),和位于Pymidinone环的2号位置的甲基组(-CH3),通常是白色到白色的晶状固体,并且由于水氧甲基组的存在而溶于极地溶解剂中,可溶于可进行氢结合.该化合物可能展示生物活动,使其对制药研究感兴趣,特别是在研制核酸类物或其他治疗剂方面.其分子结构允许各种化学反应,包括替代和氧化,这些反应可在合成化学中加以利用.与许多pyrimidine衍生物一样,它也可能参与与生物宏观分子的相互作用,影响其在医药学中的潜在应用.
- 英文名称5-(Hydroxymethyl)-2-Methylpyrimidin-4(1H)-One
- 中文名称5-(羟基甲基)-2-甲基嘧啶-4-醇
- IUPAC名称5-(hydroxymethyl)-2-methylpyrimidin-4(5H)-one
- 其它别名5-(羟甲基)-2-甲基嘧啶-4(1H)-酮; 5-(Hydroxymethyl)-2-Methylpyrimidin-4(3H)-One
- CAS编号698-30-6
- MFCD编号:MFCD08704419
- EINECS号:882-351-7
- 分子式:C6H8N2O2分子量:140.14
- 产品CID: 1693370
- 产品分类有机原料→分子砌块→芳杂环类化合物→嘧啶类化合物
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865077-08-3 85826-32-0 27058-54-4物理性质
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H-pyrimidin-4-one5-aminomethyl-2-methyl-3H-pyrimidin-4-one (2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-acetic acid amide (2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-acetic acid ethyl ester (2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-yl)-acetic acid hydrazide 4-chloro-5-chloromethyl-2-methyl-pyrimidine 4-Methylamino-2-methyl-5-hydroxymethyl-pyrimidin thi°Chrome oxythiamine chloride hydr°Chloride合成工艺路线路线简述
📜(2-Methyl-6-Oxo-1,6-Dihydro-Pyrimidin-5-yl)-Acetic Acid Hydrazide置于盐酸,水,Sodium Nitrite体系中,化学反应生成 5-羟基甲基-2-甲基嘧啶-4-醇
参考文献:Studies On Pyrimidines. I. The Preparation Of 2-Methyl-6-Oxypyrimidine-5-Acetic Acid And Some Of Its Derivatives
标题:Studies On Pyrimidines. I. The Preparation Of 2-Methyl-6-Oxypyrimidine-5-Acetic Acid And Some Of Its Derivatives
摘要:
DOI:10.1021/ja01288A044
海关参考信息
- 2905121000-正丙醇
2912110000-甲醛
2912120000-乙醛
2905141000-异丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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主要参考文献
参考标题:Thiamine Biosynthesis In Yeast-Evaluation Of 4-Hydroxy-5-Hydroxymethyl-2-Methylpyrimidine As A Precursor作者:Robert L. Baxter,A. Bryan Hartley,Henry W. S. Chan
摘要:The Putative Role Of 4-Hydroxy-5-Hydroxymethyl-2-Methylpyrimidine 2 As A Late Precursor In The Biosynthesis Of Thiamine 1 By Saccharomyces Cerevisiae Has Been Examined Using The Deuteriated Derivative 2A. To Enable Measurement Of Deuterium Incorporation Into The Pyrimidine Ring Fragment Of 1, A Procedure For The Degradation Of 1 To The Aniline Derivative 6 Using Thiaminase I From Bacillus Thiaminolyticus
合成参考文献
参考文献:10.1007/bf01982344
摘要:Deshmukh SK, Agrawal SC. Volatile metabolites of aspergilli in relation to spore germination of some keratinophilic fungi. Cellular and Molecular Life Sciences. 1984 Jun;40(6):583–4. doi: 10.1007/bf01982344.
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