CAS: 69632-32-2; (R)-(-)-3,5-Dinitro-N-(1-Phenylethyl)Benzamide

相似化合物

90761-62-9 74927-72-3 69632-31-1

上下游产品

CAS号14402-00-7 3,5-dinitro-N-(... | CAS号3886-69-9 R(+)-alpha-甲基苄胺 | CAS号99-33-2 3,5-二硝基苯甲酰氯 | CAS号99-34-3 3,5-二硝基苯甲酸 | CAS号118355-06-9 bis((R)-1-pheny...

📜3,5-二硝基苯甲酸置于4-二甲氨基吡啶,氯化亚砜,三乙胺体系中,用 二氯甲烷,苯 作为反应溶剂,化学反应 17.0H,反应生成 (R)-(-)-3,5-二硝基-N-(1-苯基乙基)苄胺
参考文献:Synthesis And Biological Evaluation Of Substituted N-Alkylphenyl-3,5-Dinitrobenzamide Analogs As Anti-Tb Agents
标题:Synthesis And Biological Evaluation Of Substituted N-Alkylphenyl-3,5-Dinitrobenzamide Analogs As Anti-Tb Agents
摘要:在此,展示了一项关于n-烷基苯基-3,5-二硝基苯胺(dnb)骨架作为强效抗结核药物的药物化学研究.进行了系列化学修饰,合成了四十三种新分子,以研究其结构-活性关系(sar),并对敏感菌株(h37Rv)进行评估.强效dnb类似物4B,7A,7C,7D,7J,7R和9A还进一步与结核分枝杆菌(mtb)的耐药株进行了测试.同时评估了它们的细胞内及杀菌潜力.细胞毒性和体内药代动力学研究表明,Dnb类似物具有可接受的安全指数,体内稳定性和生物利用度.在本研究中,化合物7A和7D在细胞外和细胞内测定中表现出了纳摩尔到亚微摩尔的最小抑菌浓度(mic).
DOI:10.1039/c3Md00366C

专利信息

专利号:US-9707553-B2
优先权日:2011-07-11
标题 :P-chirogenic organophosphorus compounds
发明人：JUGE SYLVAIN; BAYARDON JEROME; REMOND EMMANUELLE; LAUREANO HUGO; HENRY JEAN-CHRISTOPHE; LEROUX FREDERIC; COLOBERT FRANCOISE
权利人:CENTRE NAT DE LA RECH SCIENT (CNRS); UNIV BOURGOGNE; UNIV STRASBOURG; SYNTHELOR SAS
摘要:P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). n n n n n n n n n n Metal complexes comprising compounds (I) as ligands are also described. The compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.