CAS: 681128-39-2; (3,3-Difluorocyclobutyl)Methanol

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107496-54-8 1234616-13-7 1246765-49-0

上下游产品

CAS号107496-54-8 3,3-二氟环丁烷羧酸 | CAS号681128-38-1 3,3-二氟环丁烷羧酸乙酯 | CAS号541-41-3 氯甲酸乙酯 | CAS号15760-35-7 3-亚甲基环丁基甲腈 | CAS号86770-80-1 3,3-二氟环丁烷甲腈 | CAS号20249-16-5 3-氧代环丁腈 | CAS号1246765-49-0 3,3-difluor°Cyc...

3,3-二氟环丁烷羧酸乙酯置于lithium Aluminium Tetrahydride体系中,用 乙醚 作为反应溶剂,以92%的收率获得产物(3,3-二氟环丁基)甲醇
参考文献:C4 / C5 3,3-二氟环丁基取代的结构单元的多重图合成
标题:C4 / C5 3,3-二氟环丁基取代的结构单元的多重图合成
摘要:摘要 描述了一种3,3-二氟环丁基取代的结构单元(包括羧酸,胺,醇,叠氮化物,三氟硼酸酯)的多谱图合成方法.结果表明,在大多数情况下,3,3-二氟环丁烷甲酸乙酯是获得目标衍生物的方便的常用合成中间体.为了制备3,3-二氟环丁醇或-环丁酮,应采用通过二氯乙烯酮与叔丁基或苄基乙烯基醚反应的替代途径. 描述了一种3,3-二氟环丁基取代的结构单元(包括羧酸,胺,醇,叠氮化物,三氟硼酸酯)的多谱图合成方法.结果表明,在大多数情况下,3,3-二氟环丁烷甲酸乙酯是获得目标衍生物的方便的常用合成中间体.为了制备3,3-二氟环丁醇或-环丁酮,应采用通过二氯乙烯酮与叔丁基或苄基乙烯基醚反应的替代途径.
DOI:10.1055/s-0037-1610237

专利信息

专利号:WO-2023086801-A1
优先权日:2021-11-09
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-12428425-B2
优先权日:2020-05-04
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：CZABANIUK LARA C; HOPPER TIMOTHY; HOUZE JONATHAN B; PANTELEEV JANE; RESCOURIO GWENAELLA; SANTORA VINCENT; WANG HAOXUAN; WHITE RYAN D; WONG ALICE R; WU YONGWEI; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN
权利人:AMGEN INC; VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?).This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:WO-2023086799-A1
优先权日:2021-11-09
标 题:Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists
发明人：HOUZE JONATHAN B; PANDYA BHAUMIK; KAPLAN ALAN P
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ('TREM2'). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-2024409557-A1
优先权日:2023-05-09
标 题 :5,6-fused and 6,6-fused bicyclic alcohols and ethers and compositions for use as 15-prostaglandin dehydrogenase modulators
发明人：GREENMAN KEVIN LLOYD; PICKRELL ALEXANDER J; LI KEXUE; AMEGADZIE ALBERT K; WANG HUI-LING; WEIRES NICHOLAS ANTHONY; ALLEN JOHN G; BOURBEAU MATTHEW P
权利人:AMGEN INC
摘要:The present disclosure provides novel 15-hydroxy-prostaglandin dehydrogenase inhibitors, pharmaceutical compositions comprising such compounds, and methods of using such compounds and compositions in treating 15-hydroxy-prostaglandin dehydrogenase-mediated disease. Also provided are methods of making such compounds and intermediates thereof. The compounds have a general Formula (A).Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (A).

专利号:US-9199945-B2
优先权日:2013-06-21
标题:Cycloalkyl-substituted pyrimidinedione compounds
发明人：OSLOB JOHAN; ANDERSON ROBERT; AUBELE DANIELLE; EVANCHIK MARC; FOX JONATHAN CHARLES; KANE BRIAN; MCDOWELL ROBERT; RODRIGUEZ HECTOR; SONG YONGHONG; SRAN ARVINDER; LU PU-PING
权利人:MYOKARDIA INC
摘要:The present invention provides novel cycloalkyl-substituted pyrimidine dione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.