CAS: 55576-66-4; (S)-1,1'-(((2,4,6-Trihydroxy-5-(2-Methylbutanoyl)-1,3-Phenylene)Bis(Methylene))Bis(2,4-Dihydroxy-6-Methoxy-5-Methyl-3,1-Phenylene))Bis(Butan-1-One)
该化合物是一种复杂的有机化合物,其特点是分子结构复杂,包括诸如克酮,氢氧基和甲基氧组等多种功能组.由于存在多个氢氧基组,该化合物可能表现出重要的生物活动,这些组可参与氢结合并提高极地溶剂的溶性.丁诺基类组的存在表明潜在的亲脂性,这可能影响其与生物膜的相互作用.此外,(2S)配置表明的立体化学学提出了可能影响其再活性和生物相互作用的具体空间安排.
- 英文名称(S)-1,1'-(((2,4,6-Trihydroxy-5-(2-Methylbutanoyl)-1,3-Phenylene)Bis(Methylene))Bis(2,4-Dihydroxy-6-Methoxy-5-Methyl-3,1-Phenylene))Bis(Butan-1-One)
- 中文名称仙鹤草酚B
- IUPAC名称(S)-1,1'-(((2,4,6-trihydroxy-5-(2-methylbutanoyl)-1,3-phenylene)bis(methylene))bis(2,4-dihydroxy-6-methoxy-5-methyl-3,1-phenylene))bis(butan-1-one)
- 其它别名Agrimol B; (2S)-1-[3,5-Bis[[2,6-Dihydroxy-4-Methoxy-3-Methyl-5-(1-Oxobutyl)Phenyl]Methyl]-2,4,6-Trihydroxyphenyl]-2-Methyl-1-Butanone; (S)-(+)-Agrimol B; Agrimol B(P); 1-Butanone, 1-(3,5-Bis((2,6-Dihydroxy-4-Methoxy-3-Methyl-5-(1-Oxobutyl)Phenyl)Methyl)-2,4,6-Trihydroxyphenyl)-2-Methyl-, (S)-; 1-Butanone,1-[3,5-Bis[[2,6-Dihydroxy-4-Methoxy-3-Methyl-5-(1-Oxobutyl)Phenyl]Methyl]-2,4,6-Trihydroxyphenyl]-2-Methyl-,(2S)-; Agrimol B (-)-Agrimol B; 1-Butanone, 1-(3,5-Bis((2,6-Dihydroxy-4-Methoxy-3-Methyl-5-(1-Oxobutyl)Phenyl)Methyl)-2,4,6-Trihydroxyphe
- CAS编号55576-66-4
- MFCD编号:MFCD20527284
- 分子式:C37H46O12分子量:682.76
- 产品CID: 2514544
- 产品分类生物化工 → 提取物
- 相似结构搜索
- 产品信息参考
; - InChIKey: BVLHMPZMQVWDGX-INIZCTEOSA-N
- BVLHMPZMQVWDGX-INIZCTEOSA-N
- 计算化学: 氢键受体数12.0氢键供体数7.0可旋转键数15.0
物理性质
MSDS等安全信息
上下游产品
2-methyl-1-(2,4,6-trihydroxyphenyl)-1-butanone 1-4,6-dihydroxy-2-methoxy-3-methylphenylbutan-1-one 2,4,6-trihydroxytoluene 1-[3-methyl-2,4,6-trihydroxyphenyl]-1-butanone合成工艺路线路线简述
专利信息
专利号:US-2025162973-A1
优先权日:2022-02-22
标题:Methods of synthesis and uses of agrimol compounds
发明人：CHE CHI MING; FU ZHIWEN; LEUNG YIU CHUNG GULICE
权利人:VERSITECH LTD; LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:Synthetic agrimol B and derivatives thereof (“compoundsâ€?) that have anticancer properties are disclosed. Methods for synthesizing the compounds with an overall yield ≥7% are disclosed. Pharmaceutical formulations in forms suitable for the delivery of the compounds to a subject in need thereof are disclosed. Methods of using the compounds for treating a cancer, reducing a cancer, or treating or ameliorating one or more symptoms associated with a cancer, such as non-small-cell lung cancer, in a subject are also disclosed. The methods include (i) administering to the subject the pharmaceutical formulation containing one or more compounds, for one or more times. The compounds can selectively kill cancer cells and/or cancer stem cells over noncancerous cells by inducing mitochondria dysfunction and/or inhibiting ER to Golgi trafficking in the cancer cells and/or cancer stem cells.
专利号:WO-2023160543-A1
优先权日:2022-02-22
标 题 :Methods of synthesis and uses of agrimol compounds
专利号:WO-2024126769-A1
优先权日:2022-12-15
标题 :Process for preparing alpha,beta-unsaturated carbonyl compound
发明人：BONOMO LUCIA; JACOBY DENIS; FONTENY FABIEN; KELLER FABRICE
权利人:FIRMENICH & CIE
摘要:The present invention relates to the field of organic synthesis and more specifically it concerns a process for the oxidation of an allylic alcohol into an alpha,beta-unsaturated carbonyl compound in a presence of zirconium catalyst and a hydrogen acceptor.
专利号:WO-2023160543-A9
优先权日:2022-02-22
标题 :Methods of synthesis and uses of agrimol compounds
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品牌试剂参考报价(招募中)
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主要参考文献
1: Wang S, Zhang Q, Zhang Y, Shen C, Wang Z, Wu Q, Zhang Y, Li S, Qiao Y. Agrimol B suppresses adipogenesis through modulation of SIRT1-PPAR gamma signal pathway. Biochem Biophys Res Commun. 2016 Aug 26;477(3):454-60. doi: 10.1016/j.bbrc.2016.06.078. Epub 2016 Jun 16.
12:1055126. doi: 10.3389/fonc.2022.1055126.
3: Hnit SST, Ding R, Bi L, Xie C, Yao M, De Souza P, Xu L, Li Z, Dong Q. Agrimol B present in Agrimonia pilosa Ledeb impedes cell cycle progression of cancer cells through G0 state arrest. Biomed Pharmacother. 2021 Sep;141:111795. doi: 10.1016/j.biopha.2021.111795. Epub 2021 Jun 4. 29(4):481-4. doi: 10.1002/bmc.3299. Epub 2014 Jul 26. 108(4):301-305. doi: 10.1645/21-108. 24(6):431-7. Chinese. 99(3_Suppl):79-88. doi: 10.4269/ajtmh.18-0110. Epub 2018 Jul 24.
合成参考文献
参考文献:10.4269/ajtmh.18-0110
摘要:Barac R, Als D, Radhakrishnan A, Gaffey MF, Bhutta ZA, Barwick M. Implementation of Interventions for the Control of Typhoid Fever in Low- and Middle-Income Countries. Am J Trop Med Hyg. 2018 Sep;99(3_Suppl):79–88.
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