CAS: 544-31-0; Palmitoylethanolamide

上下游产品

CAS号141-43-5 2-氨基乙醇 | CAS号57-10-3 棕榈酸 | CAS号112-67-4 棕榈酰氯 | CAS号693-38-9 棕榈酸乙烯酯 | CAS号628-97-7 棕榈酸乙酯 | CAS号100663-86-3 (Z)-phenyl(pyri... | CAS号555-44-2 (三)棕榈酸甘油酯 | CAS号120246-99-3 palmitoyl ethyl... | CAS号74058-64-3 1-(2-sulfanylid... | CAS号7596-88-5 N-月桂酰甘氨酸 | CAS号14246-55-0 N-肉豆蔻酰甘氨酸 | CAS号2441-41-0 棕榈酰甘氨酸 | CAS号6333-54-6 硬脂酰甘氨酸 | CAS号14246-53-8 辛酰甘氨酸 | CAS号36919-66-1 2-pentadecyl-4,...

棕榈酸置于草酰氯,三乙胺,N,N-二甲基甲酰胺体系中,用 二氯甲烷 作为反应溶剂,化学反应 6.5H,反应生成 十六酰胺乙醇
参考文献:Oea衍生物作为faah抑制剂的设计,合成和comfa研究
标题:Oea衍生物作为faah抑制剂的设计,合成和comfa研究
摘要:总共设计,合成和表征了26种新颖的油酰基乙醇酰胺衍生物.筛选所有合成的目标化合物对脂肪酸酰胺水解酶的抑制活性.其中13种化合物在100μm的浓度下可抑制50%的脂肪酸酰胺水解酶.在这些化合物中,活性最高的是化合物9,当浓度为100 µm时,其抑制脂肪酸酰胺水解酶活性的比例为98.35%.根据获得的生物活性数据进行比较分子场分析,得出具有可靠预测能力的统计可靠的比较分子场分析模型(r 2 = 0.978,Q 2 = 0.613).
DOI:10.1007/s00044-017-1995-6

专利信息

专利号:US-9522192-B2
优先权日:2012-12-13
标 题:Polyethylene glycol derivatives of palmitoylethanolamide and analogous acylethanolamides
发明人：CALIGNANO ANTONIO; D'AGOSTINO GIUSEPPE; LANERI SONIA; MELI ROSARIA; OSTACOLO CARMINE; RUSSO ROBERTO; SACCHI ANTONIA; TRONINO DIANA; DELLA VALLE FRANCESCO; DELLA VALLE MARIA FEDERICA; MARCOLONGO GABRIELE
权利人:EPITECH GROUP SRL
摘要:The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues—particularly in the skin and mucosae—and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.

专利号:WO-2006109321-A1
优先权日:2005-04-15
标题:An improved process for the synthesis of palmidrol
发明人：SURI SANJAY; KASHYAP TAPAN; SINGH JAGAT
权利人:MOREPEN LAB LTD; SURI SANJAY; KASHYAP TAPAN; SINGH JAGAT
摘要:The process of this invention comprises preparing anhydride of palmitic acid and alkyl or cycloalkyl haloformate by any conventional method, reacting anhydride so formed with ethnolamine in-situ, and isolating the product by any known methods such as solvent recovery or filtration followed by purifying the title product by recrystallization using organic solvents if so desired.

专利号:US-12194020-B2
优先权日:2017-12-22
标 题:Reversing baldness through cannabinoid receptor activation
发明人：POSTREL RICHARD
权利人:POSTREL RICHARD
摘要:This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.

专利号:US-4761404-A
优先权日:1985-07-01
标题:Phospholipid analogs useful as PAF synthesis inhibitors
发明人：BUGIANESI ROBERT L; PONPIPOM MITREE M; RUPPRECHT KATHLEEN M
权利人:MERCK & CO INC
摘要:There are disclosed phospholipid analogs which are useful as PAF synthesis inhibitors. These compounds inhibit PAF (platelet-activating factor) biosynthesis and are thereby useful in the treatment of various diseases or disorders mediated by the PAF such as, for example, pain, fever, inflammation, cardiovascular disorder, asthma, lung edema, allergic disorders, skin diseases, psoriasis, and adult respiratory distress syndrome.

专利号:US-12084407-B2
优先权日:2019-11-26
标 题 :Cannabigerol derivatives and use thereof as cannabinoid receptor modulators
发明人：AHMAR SIAWASH; GNANASEKARAN KRISHNA KUMAR; OMEARA JEFFREY ALAN
权利人:CANOPY GROWTH CORP
摘要:The synthesis of a range of pentylbezene-1,3-diol compounds of formula I is disclosed. These compounds bind to cannabinoid 1 and 2 receptors (CB1 and CB2), and are thus presumed to be useful in modulating the activity of such receptors. Accordingly, the use of such synthetic cannabinoids in the treatment of various disorders mediated by CB1 and CB2 is contemplated.

专利号:US-2005234244-A1
优先权日:2004-04-20
标题:Synthesis of COX-2 and FAAH inhibitors
发明人：BARTOLINI WILMIN; CALI BRIAN M; CHEN BARBARA; CHIEN YUEH-TYNG; CURRIE MARK G; MILNE G T; PEARSON JAMES P; TALLEY JOHN J; ZIMMERMAN CRAIG
权利人:BARTOLINI WILMIN; CALI BRIAN M; CHEN BARBARA; CHIEN YUEH-TYNG; CURRIE MARK G; MILNE G T; PEARSON JAMES P; TALLEY JOHN J; ZIMMERMAN CRAIG
摘要:Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.