CAS: 5272-36-6; 3-(Trimethylsilyl)Propargyl Alcohol

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CAS号75-77-4 三甲基氯硅烷 | CAS号107-19-7 丙炔醇 | CAS号50-00-0 甲醛 | CAS号1066-54-2 三甲基硅基乙炔 | CAS号50965-66-7 三甲基(3-((三甲基硅烷基)... | CAS号36551-06-1 trimethyl-[3-(o... | CAS号5582-62-7 3-三甲基硅氧基-1-丙炔 | CAS号75-78-5 二甲基二氯硅烷 | CAS号1092574-62-3 methyl 2-((3-(t... | CAS号1068-55-9 异丙基氯化镁 | CAS号59376-64-6 反式-3-(三甲基硅基)烯丙醇 | CAS号62861-80-7 3-trimethylsily... | CAS号5683-31-8 3-(三甲基硅基)丙炔酸 | CAS号14657-22-8 trimethyl(propa... | CAS号141862-01-3 methyl 3-trimet... | CAS号42134-49-6 (3-三甲基硅基-2-丙炔基)... | CAS号289673-81-0 2-diazonio-1-me... | CAS号2917-47-7 3-(三甲基甲硅烷基)-1-丙醇 | CAS号6224-91-5 1-(三甲基硅基)丙炔

丙炔氧基三甲基硅烷置于仲丁基锂体系中,用 四氢呋喃,正己烷 作为反应溶剂,化学反应 6.0H,以45%的收率获得产物三甲硅基丙炔醇
参考文献:有机锂试剂性质对丙炔hc≡cch2Osir3中r3Si基团o->csp迁移可能性的影响
标题:有机锂试剂性质对丙炔hc≡cch2Osir3中r3Si基团o->csp迁移可能性的影响
摘要:研究了在用有机锂试剂 (Rli) 处理后,R3Si 基团在末端炔醇的甲硅烷基醚中发生 O->csp 1,4-迁移的可能性.在 3-三甲基甲硅烷氧基丙炔的情况下,根据 Rli 的性质,Si-O 键的杂解是通过去质子化形成的乙炔的作用发生的,形成 3-三甲基甲硅烷基丙-2-Yn-1-Ol 三甲基甲硅烷基醚,或在金属化剂的作用下与炔丙醇形成.me3Si 基团的 O->csp 1,4-迁移的实现需要使用温和的有机锂试剂(六甲基二硅氮烷锂和二异丙基酰胺).在与反应中心键合的碳原子或硅原子周围具有空间位阻的甲硅烷基醚不与所研究的有机锂试剂反应.
DOI:10.1007/s11172-017-2012-4

专利信息

专利号:US-12006540-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis
发明人：JU JINGYUE; LI XIAOXU; CHEN XIN; LI ZENGMIN; KUMAR SHIV; SHI SHUNDI; GUO CHENG; REN JIANYI; HSIEH MIN-KANG; CHIEN MINCHEN; TAO CHUANJUAN; ERTURK ECE; KALACHIKOV SERGEY; RUSSO JAMES J
权利人:UNIV COLUMBIA
摘要:Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

专利号:US-9006345-B2
优先权日:2011-03-25
标题 :Heterotrifunctional molecules and methods for the synthesis of dendrimeric materials
发明人：LANCASTER JEFFREY; KOBERSTEIN JEFFREY T; TURRO NICHOLAS J
权利人:LANCASTER JEFFREY; KOBERSTEIN JEFFREY T; TURRO NICHOLAS J; UNIV COLUMBIA
摘要:In one aspect, the present invention is directed to dendrimers comprised of macromolecules and trifunctional branches. In another aspect, the invention relates to methods for generating dendrimeric compositions comprising macromolecules and trifunctional branches. In certain embodiments, the radial density of the dendrimeric composition is controlled by selective incorporation of branches.

专利号:US-11959137-B2
优先权日:2015-09-28
标题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis

专利号:US-2024376536-A1
优先权日:2015-09-28
标题 :Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2022411860-A1
优先权日:2015-09-28
标题:Design and synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis

专利号:US-2023160000-A1
优先权日:2015-09-28
标 题:Synthesis of novel disulfide linker based nucleotides as reversible terminators for dna sequencing by synthesis