专利号:US-2008176857-A1 优先权日:2005-03-25 标题 :4-Piperazinnylthieno[2,3-d]Pyrimidine Compounds as Platelet Aggregation Inhibitors 发明人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH 权利人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: n n n n n n n n n n wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2 , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
专利号:US-7482445-B2 优先权日:2003-06-18 标 题:Crystalline carbapenem intermediate 发明人:AIHARA KAZUHIRO; HASEGAWA TOSHIFUMI; KITAHARA SHINICHI; WATANABE TAKASHI; ANDO TAKASHI; SAWABE TAKEHIKO; SHITARA EIKI; ATSUMI KUNIO; OTA KAZUMI 权利人:MEIJI SEIKA KAISHA 摘要:This invention relates to crystals of compounds of formula (I), wherein TBS represents t-butyldimethylsilyl, and Ph represents phenyl, or its salt or solvate. Compounds of formula (I) are synthesis intermediates of 2-substituted-1β-methyl carbapenem compounds useful as antimicrobial agents. The crystals of the present invention have excellent handleability and can realize the production of carbapenem compounds having excellent antimicrobial activity in a simpler manner with improved yield and purity.
专利号:CN-117447472-A 优先权日:2023-10-10 标 题 :A kind of synthesis method of 2,4-diamino-6-chloromethylpteridine