CAS: 453-11-2; 1-Chloro-3-Fluoropropan-2-Ol

相似化合物

19141-39-0 37493-16-6

上下游产品

epichlorohydrin 1,3-Dichloro-2-propanol 1,2-Dichloropropane 1-Chloro-3-fluoro-prop-2-one Guajacyl-(2-hydroxy-3-fluor-propyl)-aether 1-Fluoro-3-phenoxypropan-2-ol Fluoromisonidazole

📜环氧氟丙烷置于sodium Chloride体系中,用 Aq. Acetate Buffer 作为反应溶剂,化学反应 1.0H,以63%的收率获得产物1-氯-3-氟-2-丙醇
参考文献:Halohydrin Dehalogenase-Catalysed Transformations Of Epifluorohydrin
标题:Halohydrin Dehalogenase-Catalysed Transformations Of Epifluorohydrin
摘要:Biocatalytic Ring-Opening Of Epifluorohydrin Has Been Performed By Using Halohydrin Dehalogenase. The Enzyme From Mycobacterium Sp. Gp1 (Hheb2) Catalysed Reaction With High Regioselectivity And Low Enantioselectivity In The Presence Of Different Nucleophiles,Producing Racemic 1-Substituted 3-Fluoro-2-Propanols. No By-Products Resulting From The Ring-Closure Reaction Have Been Detected,Confirming That Vicinal Fluoro Alcohols Are Not Substrates For Hhdh. Four Different 3-Fiuoro-2-Propanols Were Prepared Under Mild Reaction Conditions Starting From Epifluorohydrin. High Conversions Of 85-100% Were Reached Within 1-3 H And Depending On The Nucleophile Used Products Were Isolated In 31-92% Yields. (C) 2017 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetlet.2017.12.054

专利信息

专利号:EP-1542943-A1
优先权日:2002-08-06
标 题:General synthesis of fluorine compounds

专利号:WO-2004014820-A2
优先权日:2002-08-06
标 题 :General synthesis of fluorine compounds
发明人：BRAUN MAX; BROSCH CARSTEN
权利人:SOLVAY FLUOR & DERIVATE; BRAUN MAX; BROSCH CARSTEN