CAS: 4328-13-6; Tetrahexylammonium Bromide

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2138-24-1 32503-34-7 13028-71-2

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CAS号1392488-21-9 | CAS号100-39-0 溴化苄 | CAS号105140-20-3 methanesulfonat... | CAS号106-94-5 溴代丙烷 | CAS号4656-81-9 四正己基高氯酸铵 | CAS号17756-56-8 四己基氢氧化铵

📜,溴甲苯 以 乙腈 作为反应溶剂,化学反应生成 (Benzyloxy)Benzene,四己基溴化铵,苯酚
参考文献:电荷分离,有效浓度和聚集体形成对苯酚相转移催化烷基化的影响
标题:电荷分离,有效浓度和聚集体形成对苯酚相转移催化烷基化的影响
摘要:详细研究了影响相转移催化(ptc)下苯酚烷基化速率的因素.六种线性对称四烷基铵阳离子,Me(4)N(+),Et(4)N(+),(N-Pr)(4)N(+),(N-Bu)(4)N(+),(N-Hex)(4)N(+) 和 (N-oct)(4)N(+) 进行了检查,以比较阳离子半径和亲脂性对烷基化速率的影响.制备了四烷基苯氧基铵.酚盐,其固有反应活性由与正丁基溴在均相溶液中的初始烷基化速率确定.使用季铵溴化物催化剂在 Ptc 条件下(在萃取机制下)测定相同的四烷基酚盐的催化活性.在均相溶液中,Me(4)N(+) 到 (N-oct)(4)N(+) 的反应性范围很小(6.8 倍).相比之下,在 Ptc 条件下,观测到更大范围的反应性(663 倍).有机相中四烷基酚盐的有效浓度被确定为影响催化剂活性的主要因素.此外,有机相中活性苯氧化物的滴定证实了苯酚和苯酚钾与 (N-Bu)(4)N(+),(N-Hex)(4)N(+)
DOI:10.1021/ja304808U

专利信息

专利号:US-4592874-A
优先权日:1980-05-14
标 题:Process for the synthesis of alpha-chlorinated chloroformates
发明人：CAGNON GUY C; PITEAU MARC D; SENET JEAN-PIERRE G; OLOFSON ROY A; MARTZ JONATHAN T
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:Process for the synthesis of alpha -chlorinated chloroformates, and new alpha -chlorinated chloroformates. The invention relates to a new process for the manufacture of alpha -chlorinated chloroformates and, to new alpha -chlorinated chloroformates as new industrial products. The process according to the invention consists of a synthesis, by catalytic phosgenation, of alpha -chlorinated chloroformates of the formula: in which: R represents a substituted or unsubstituted hydrocarbon radical and m represents an integer superior or equal to one, this synthesis consisting in reacting phosgene with the aldehyde R-CHO)m, in the presence of a catalyst which is an organic or inorganic substance which is capable in a medium containing an aldehyde of the formula R-CHO)m, phosgene and, possibly, a solvent, of generating a pair of ions one of which is an halogenide anion and the other is a cation which is sufficiently separated from said halogenide anion so as to give to the latter a nucleophilic power enabling it to react with the function(s) aldehyde of the molecule R-CHO)m.

专利号:US-2009253746-A1
优先权日:2005-11-14
标题 :Synthesis and Preparations of Intermediates and New Polymorphs Thereof Useful For The Preparation Of Donepezil Hydrochlcoride
发明人：SOLDEVILLA MADRID NURIA
权利人:SOLDEVILLA MADRID NURIA
摘要:The invention relates to an improved process for preparing 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyin-dan- 1 -one (a key intermediate in the synthesis of donepezil hydrochloride), crystalline polymorph forms of this key intermediate and their use thereof for producing donepezil hydrochloride. In particular, the invention provides an improved method for producing the intermediate 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyindan-1-one. The process includes reacting 5,6-dimethoxyin-dan- 1 -one with 1-benzylpiperidine-4-carbaldehyde using potassium hydroxide in an aqueous solvent. The aqueous solvent can be a mixture of an organic solvent and water Where the organic solvent is not miscible with water, the reaction may be performed in the presence of a phase transfer catalyst.

专利号:EP-3567040-B1
优先权日:2013-06-24
标 题 :Method for the preparation of intermediates useful for the synthesis of [1,2,4]-triazolo[4,3-a]pyridines

专利号:US-2008214386-A1
优先权日:2004-03-01
标题:Catalyst for Cyclic Carbonate Synthesis
发明人：TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU
权利人:TAKAHASHI TOSHIKAZU; WATAHIKI TSUTOMU; YASUDA HIROYUKI; SAKAKURA TOSHIYASU
摘要:Provided are a solid catalyst which gives a cyclic carbonate at a high yield and a high selectivity, which is stable and which may be readily separated after reaction; and a method of industrially advantageous, inexpensive and safe production of a cyclic carbonate by the use of the catalyst. The catalyst contains an inorganic solid substance having a surface modified with an ionic substance containing a Group 15 element; or contains an ionic substance containing a Group 15 element, and an inorganic solid substance. The modifying group for surface modification of an inorganic solid substance is an ionic substance containing a Group 15 element. The ionic substance containing a Group 15 element is at least one substance selected from organic phosphonium salts, organic ammonium salts, organic arsonium salts and organic antimonium salts.

专利号:EP-3567040-A1
优先权日:2013-06-24
标题 :Method for the preparation of intermediates useful for the synthesis of [1,2,4]-triazolo[4,3-a]pyridines

专利号:KR-20180074695-A
优先权日:2015-10-26
标题 :Synthesis of 2-alkyl-4-trifluoromethyl-3-alkylsulfonylbenzoic acid