CAS: 43064-12-6; 4-Phenyl-1,2,3,6-Tetrahydropyridine Hydrochloride

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📜1-苄基-1,2,3,6-四氢-4-苯基吡啶置于甲醇体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 2.5H,反应生成 1,2,3,6-四氢-4-苯基吡啶盐酸盐
参考文献:Synthesis And Sar Study Of 4-Arylpiperidines And 4-Aryl-1,2,3,6-Tetrahydropyridines As 5-Ht2C Agonists
标题:Synthesis And Sar Study Of 4-Arylpiperidines And 4-Aryl-1,2,3,6-Tetrahydropyridines As 5-Ht2C Agonists
摘要:A Series Of Substituted 4-Arylpiperidines And A Smaller Family Of 4-Aryl-1,2,3,6-Tetrahydropyridines Were Synthesized And Their Biological Activity At The 5-Ht2C Receptor Studied To Determine Whether Either Series Showed Noteworthy Agonist Activity. Structure-Activity Relationships Were Developed From The Performed Receptor Binding Assays And Functional Studies,And The Results Of The Analysis Are Presented Herein. Crown Copyright (C) 2012 Published By Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2012.01.122

专利信息

专利号:US-4939137-A
优先权日:1989-06-28
标 题:Ring-fused thienopyrimidinedione derivatives
发明人：RUSSELL RONALD K; RAMPULLA RICHARD A
权利人:ORTHO PHARMA CORP
摘要:The synthesis of ring-fused thienopyrimidinedione derivatives is described. The novel ring-fused thienopyrimidinedione derivatives are generally vasodilating agents and antihypertensive agents and as such are useful as cardiovascular agents.

专利号:US-5710277-A
优先权日:1994-09-12
标题:Process for R (+) 1,2,3,6-tetrahydro-4-phenyl-1- (3-phenyl-3-cyclohexen-1-yl)methyl!pyridine, a central nervous system agent
发明人：BUTLER DONALD EUGENE; GAILEY JODETTE; LE TUNG VAN; SMITH III WILLIAM JOHN; WUSTROW DAVID JUERGEN
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of R(+)1,2,3,6-tetrahydro-4-phenyl-1-[(3-phenyl-3-cyclohexen-1-yl)methyl]pyridine by a novel synthesis is described where 5-oxo-3-phenyl-3-cyclohexene-carboxylic acid is converted in five operations to the desired product, as well as processes for the resolution of 5-oxo-3-phenyl-3-cyclohexenecarboxylic acid using cinchonidine to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboylic acid or alpha -chymotrypsin to selectively hydrolyze n-butyl 5-oxo-3-phenyl-3-cycohexenecarboxylate to afford (S)5-oxo-3-phenyl-3-cyclohexenecarboxylic acid as well as other valuable intermediates used in the processes.