CAS: 3469-69-0; 4-Iodopyrazole

相似化合物

121669-70-3 191980-54-8 50877-42-4

上下游产品

CAS号288-13-1 吡唑 | CAS号28466-26-4 4-氨基吡唑 | CAS号50877-42-4 1-苄基-4-碘-1H-吡唑 | CAS号39806-90-1 1-甲基-4-碘-吡唑 | CAS号918487-09-9 4-碘-1-异丁基-1H-吡唑 | CAS号191980-54-8 4-碘-1-三苯甲基-1H-吡唑 | CAS号98027-52-2 1-乙酰基-4-碘-1H-吡唑 | CAS号2075-46-9 4-硝基吡唑 | CAS号877399-73-0 1-B°C-4-(4-碘-1H... | CAS号116228-38-7 1-苯甲酰基-4-碘吡唑 | CAS号121669-70-3 4-碘吡唑-1-甲酸叔丁酯 | CAS号313350-82-2 1-异丙基-4-碘吡唑

4-溴吡唑置于copper(L) Iodide,(1R,2R)-(-)-N,N'-二甲基-1,2-环己二胺,Sodium Iodide体系中,用 1,4-二氧六环,水 作为反应溶剂,180.0 °C,1.21 Mpa 条件下,反应 0.5H,以75%的收率获得产物4-碘吡唑
参考文献:连续流动条件下快速高效的铜催化(杂)芳烃的finkelstein反应
标题:连续流动条件下快速高效的铜催化(杂)芳烃的finkelstein反应
摘要:已经开发出一种使用连续流反应生成各种芳基碘化物的铜催化(杂)芳烃的finkelstein反应的通用,快速,有效的方法.所描述的方法可以耐受各种官能团,包括n-H和o-H基团.另外,代替分离,在两个不同的多步连续流工艺(酰胺化和mg-I交换/亲核加成)中使用了芳基碘溶液,以证明该方法的灵活性.
DOI:10.1002/anie.201409595

专利信息

专利号:US-2024309003-A1
优先权日:2021-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-9901901-B2
优先权日:2012-05-21
标 题 :Selective extraction of anions from solution
发明人：MEZEI GELLERT
权利人:WESTERN MICHIGAN UNIV RESEARCH FOUNDATION; THE BOARD OF TRUSTEES OF WESTERN MICHIGAN UNIV
摘要:A method of selectively extracting anions from an aqueous solution using an anion encapsulating aggregate formed upon the addition of a solvent, a copper contributor, a hydroxide contributor, a counterion contributor, and pyrazole to an aqueous solution containing the anions, or upon the addition of a solvent, a polymeric chain of [Cu II (μ-OH)(μ-pz)] ∞ and a counterion contributor to the aqueous solution. The aggregates include compounds of the formula cis Cu II x (OR 1 ) y (R 2 pz) z , where R 1 is H or an alkyl group, R 2 is H, or an alkyl group or a charged group, pz is pyrazolate and each of x, y, and z is an integer between about 1 and about 40. In addition, ligand-containing anion encapsulating aggregates can be formed by synthesis with a lig-and-bound pyrazole or by substituting the ligand-bound pyrazole for the pyrazole incorporated in the aggregate.

专利号:US-10087197-B2
优先权日:2012-05-21
标 题:Selective extraction of anions from solution
发明人：MEZEI GELLERT
权利人:WESTERN MICHIGAN UNIV RESEARCH FOUNDATION
摘要:A method of selectively extracting anions from an aqueous solution using an anion encapsulating aggregate formed upon the addition of a solvent, a copper contributor, a hydroxide contributor, an optional counterion contributor, and at least one encapsulating anion to an aqueous solution containing the anions, or upon the addition of a solvent, a polymeric chain of [CuII(μ-OH)(μ-ea)]∞ and optionally, a counterion contributor to the aqueous solution. The aggregates include compounds of the formula cis-CuIIx(OR1)y(R2ea)z, where R1 is H or an alkyl group, R2 is H, or an alkyl group or a charged group, ea is an encapsulating anion, and each of x, y, and z is equal to an integer between about 1 and 40, inclusive. In addition, anion encapsulating aggregates can be formed by synthesis with alternate encapsulating anions by substituting alternate encapsulating anions for the encapsulating anion incorporated in the aggregate.

专利号:US-6852711-B2
优先权日:1998-09-11
标题:HIV protease inhibitors
发明人：BOYER JR FREDERICK EARL; DOMAGALA JOHN MICHAEL; ELLSWORTH EDMUND LEE; GAJDA CHRISTOPHER ANDREW; HAGEN SUSAN ELIZABETH; LOVDAHL MICHAEL JAMES; LUNNEY ELIZABETH ANN; MARKOSKI LARRY JAMES; PRASAD JOSYULA VENKATA NAGENDR; TAIT BRADLEY DEAN
权利人:AGOURON PHARMA
摘要:The present invention relates to novel dihydropyrones with tethered heterocycles having improved pharmacologic properties which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The dihydropyrones are useful in the development of therapies for the treatment of viral infections and diseases, including AIDS. The present invention is also directed to methods of synthesis of the dihydropyrones and intermediates useful in the preparation of the final compounds.

专利号:EP-3590340-B1
优先权日:2010-09-01
标 题:Intermediates for the synthesis of fungicidal pyrazoles

专利号:US-6518266-B1
优先权日:1999-07-22
标题:1- Aryl-3-thioalkyl pyrazoles, the synthesis thereof and the use thereof as insecticides
发明人：DHANOA DALJIT S; DOLLER DARIO; MEEGALLA SANATH; SOLL RICHARD M; WISNEWSKI NANCY; SILVER GARY; STINCHCOMB DAN T; SEWARD R LEE; AGRAFIOTIS DIMITRIS; SHA DEYOU
权利人:DIMENSIONAL PHARMACEUTICALS 3; HESKA CORP
摘要:The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I:or a salt thereof, whereR1 represents R5O, R5SO2, R5SO or R5S in which R5 is as defined herein;X is halo, cyano, C1-6 alkoxycarbonyl, C2-6 alkynyl, optionally substituted C6-14 aryl or an optionally substituted 5- to 7-membered heteroaromatic ring linked to thiazole via a carbon-carbon bond;R2 is hydrogen, amino, chloro, bromo, iodo, cyano, C1-6 alkoxy, C1-6 alkyl or C6-10 aryl; andR3-R7 each represent hydrogen, halogen, straight- or branched-chain C1-4 alkyl or C1-4 alkoxy, either of which is unsubstituted or substituted by one or more halogen atoms, straight- or branched-chain C1-4 alkylthio or C1-4 alkylsulphinyl, either of which is substituted by one or more halogen atoms, nitro, cyano, or straight- or branched-chain C1-4 alkylsulphonyl group which is unsubstituted or substituted by one or more halogen atoms.