CAS: 303-26-4; 1-((4-Chlorophenyl)(Phenyl)Methyl)Piperazine

上下游产品

CAS号110-85-0 哌嗪 | CAS号134-83-8 4-氯二苯氯甲烷 | CAS号119-56-2 4-氯二苯甲醇 | CAS号1155402-49-5 phenyl 4-((4-ch... | CAS号628717-39-5 4-nitrophenyl 4... | CAS号134-85-0 4-氯二苯甲酮 | CAS号104-88-1 对氯苯甲醛 | CAS号1161573-31-4 (R)-(-)-1-[(4-c... | CAS号439858-21-6 (S)-1-[(4-氯苯基)苯甲基]哌嗪 | CAS号298-55-5 氯西尼嗪 | CAS号82-93-9 氯环嗪 | CAS号83881-37-2 西替利嗪酰胺 | CAS号83881-46-3 左西替利杂质8 | CAS号2192-20-3 盐酸羟嗪 | CAS号1104-22-9 盐酸美克洛嗪 | CAS号109806-71-5 4-氯双苯基甲哌乙醇 | CAS号114624-65-6 3-[[4-[(4-chlor...

N-(2-Hydroxyethyl)-12-Bromododecanesulfonamide 以 水,N,N-二异丙基乙胺 用作溶剂,化学反应生成1-(4-氯二苯甲基)哌嗪
参考文献:Us6172228
标题:Us6172228

专利信息

专利号:US-8350031-B2
优先权日:2008-06-02
标 题:Processes for the synthesis of levocetirizine and intermediates for use therein
发明人：RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
权利人:CIPLA LTD; RAO DHARMARAJ RAMACHANDRA; KANKAN RAJENDRA NARAYANRAO; GHAGARE MARUTI; CHIKHALIKAR SANDIP VASANT
摘要:The present invention provides a compound of formula (IV) n nwherein R is Cl, Br, NO 2 , OH or OR′, and R′ is alkyl, and its use in the synthesis of levocetirizine, including its use in the synthesis of (−)-1-[(4-chlorophenyl)-phenylmethyl]piperazine, an intermediate useful in the synthesis of levocetirizine. The present invention also provides compounds (II) and (III) which are useful in the synthesis of compound (IV).

专利号:US-7678789-B2
优先权日:2005-02-11
标 题 :[1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-S-transferase and NADPH quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular
发明人：FEENSTRA ROELOF W; KEIZER HISKIAS G; PRAS-RAVES MARIA L; VAN VLIET BERNARD J; VAN SCHARRENBURG GUSTAAF J M
权利人:SOLVAY PHARM BV
摘要:The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]-dithiazolidine-3,5-diylidene-diamine derivatives as inducers of gluthathione-S-transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): n nwhereinn nwherein the symbols have the meanings given in the specification.

专利号:EP-1851209-B1
优先权日:2005-02-11
标题:[1,2,4]-dithiazoli(di)ne derivatives, inducers of gluthathione-s-transferase and nadph quinone oxido-reductase, for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular
发明人：FEENSTRA ROELOF W; KEIZER HISKIAS G; PRAS-RAVES MARIA L; VAN VLIET BERNARD J; VAN SCHARRENBURG GUSTAAF J
权利人:ABBOTT HEALTHCARE PRODUCTS BV
摘要:The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]- dithiazolidine-3,5-diylidene-diamine derivatives as inducers of glutha-thione-S- transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament useful in the for prophylaxis and treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein the symbols have the meanings given in the specification.

专利号:US-7381821-B2
优先权日:2003-01-23
标 题 :Piperazine derivatives and their use as synthesis intermediates
发明人：ATES CELAL; CAVOY EMILE; BOUVY DIDIER
权利人:UCB SA
摘要:The present invention relates to new enantiomerically pure piperazine derivatives of formula (I) wherein Y represents hydroxy or a leaving group and n is 1, 2, 3, 4 or 5, and to their use as synthesis intermediates, especially for the preparation of pharmaceutically active compounds

专利号:RU-2118320-C1
优先权日:1993-03-15
标 题:Enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-4-[(4-methylphenyl)sulfonyl]- -piperazine, method of their synthesis, method of synthesis of enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-piperazine, enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-piperazine, enantiomers of 1-[(4-chlorophenyl)phenylmethyl]-piperazine derivatives

专利号:US-2007275962-A1
优先权日:2003-09-10
标 题:Heterobicyclic Compounds as Pharmaceutically Active Agents
发明人：KOUL ANIL; KLEBL BERT; MULLER GERHARD; MISSIO ANDREA; SCHWAB WILFRIED; HAFENBRADL DORIS; NEUMANN LARS; SOMMER MARC-NICOLA; MULLER STEFAN; HOPPE EDMUND; FREISLEBEN ACHIM; BACKES ALEXANDER; HARTUNG CHRISTIAN; FELBER BEATRICE; ZECH BIRGIT; ENGKVIST OLA; KERI GYORGY; ORFI LASZLO; BANHEGYI PETER; GREFF ZOLTAN; HORVATH ZOLTAN; VARGA ZOLTAN; MARKO PETER; PATO JANOS; SZABADKAI ISTVAN; SZEKELYHID ZSOLT; WACZEK FRIGYES
权利人:GPC BIOTECH AG
摘要:Described are heterobicyclic compounds such as 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]thiopyran 3-carboxylic acid amides, 4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid amides, or benzo[b]thiophene-3-carboxylic acid amides and pharmaceutically acceptable salts thereof, the use of these derivatives for the prophylaxis and/or treatment of various diseases such as infectious diseases, including mycobacteriainduced infections and opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, as well as compositions containing at least one heterobicyclic compound and/or pharmaceutically acceptable salts thereof. Furthermore, reaction procedures for the synthesis of the heterobicyclic compound are disclosed.