CAS: 212504-89-7; (3R,4R,5S)-Ethyl 4,5-Diamino-3-(Pentan-3-Yloxy)Cyclohex-1-Enecarboxylate (Oseltamivir Impurity)

上下游产品

(3R,4R,5S)-4,5-bis(tert-butoxycarbonylamino)-1-cyano-3-(1-ethylpropoxy)cyclohexene ethanol pentan-3-yl 2,2,2-trichloroacetimidate (+/-)-ethyl (1R,5R,6S)-5-acetoxy-6-nitr°Cyclohex-3-ene-1-carboxylate (3R,4R,5S)-ethyl 4-amino-5-(tert-butoxycarbonylamino)-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate (3R,4R,5S)-ethyl 4-acetamido-5-((tert-butoxycarbonyl)amino)-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate oseltamivir phosphate

📜奥司他韦置于盐酸,水,碳酸氢钠体系中,用 乙醇,水 用作溶剂,化学反应 5.0H,以35%的收率获得奥司他韦杂质8
参考文献:The First Synthesis Of [11C]Oseltamivir: A Tool For Elucidating The Relationship Between Tamiflu And Its Adverse Effects On The Central Nervous System
标题:The First Synthesis Of [11C]Oseltamivir: A Tool For Elucidating The Relationship Between Tamiflu And Its Adverse Effects On The Central Nervous System
摘要:磷酸奥司他韦(达菲®)是一种在许多国家获批的抗流感药物.最近,在日本,有报道称年轻患者在使用达菲后出现了中枢神经系统的副作用.为了阐明达菲与其副作用之间的关系,通过两步反应合成11C标记的奥司他韦,其中包括用[1-11C]乙酰氯进行[11C]乙酰化.从大约37.0 Gbq的[11C]Co2开始,合成的最后阶段(eos)在轰击结束后的36-39分钟内获得了1.2-1.8 Gbq(n=5)的[11C]奥司他韦.在eos时,放射化学纯度和比活性分别大于98%和2.7-6.3 Gbq/µmol.版权所有 © 2009 John Wiley & Sons,Ltd.
Doi:10.1002/jlcr.1604