CAS: 133-59-5; 2-Methylbenzenesulfonyl Chloride

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CAS号64846-49-7 1-(methoxymethy... | CAS号137-06-4 邻硫甲酚 | CAS号16419-60-6 2-甲基苯硼酸 | CAS号82125-34-6 S-(2-methylphen... | CAS号108-88-3 甲苯 | CAS号5153-67-3 反式硝基苯乙烯 | CAS号2028-34-4 o-methylbenzene... | CAS号102537-97-3 isopropyl tolue... | CAS号15046-75-0 o-Toluenesulfon... | CAS号1084-17-9 2-chloro-4-meth... | CAS号36946-70-0 2-氨基吲哚盐酸盐 | CAS号18684-09-8 2-methylbenzene... | CAS号18271-18-6 4-methyl-N-naph... | CAS号23373-38-8 2-甲基苯磺酸甲酯 | CAS号23276-69-9 1-甲烷磺酰基-2-甲苯 | CAS号95-49-8 邻氯甲苯 | CAS号611-19-8 邻氯氯苄 | CAS号97-00-7 1-氯-2,4-二硝基苯

邻甲苯胺置于盐酸,Sodium Nitrite,氯化亚砜,Copper(L) Chloride体系中,用 水 用作溶剂,以73.6%的收率获得邻甲苯磺酰氯
参考文献:取代的苯磺酰氯的制备方法
标题:取代的苯磺酰氯的制备方法
摘要:本发明提供了一种取代的苯磺酰氯的制备方法,所述取代的苯磺酰氯的制备方法,包含以下步骤:将式i结构的苯胺化合物经重氮化反应得到式ii结构的氟硼酸重氮盐;经由所述式ii结构的氟硼酸重氮盐得到式iii结构的取代的苯磺酰氯;其中,R选自邻位氯,溴,甲基,氯甲基,溴甲基,硝基,氰基,乙酰基,间位氯,溴,甲基,氯甲基,溴甲基,硝基,氰基,乙酰基,对位氯,溴,甲基,氯甲基,溴甲基,硝基,氰基,乙酰基中任意一种.根据本发明提供的取代的苯磺酰氯的制备方法,反应过程简单,易于操作,效果理想,适合工业化生产.

专利信息

专利号:US-11427530-B2
优先权日:2018-02-09
标 题 :Synthesis of 4-chlorokynurenines and intermediates
发明人：LEVIN DANIEL; LEEMING PETER; EISENREICH EMERICH; LIU XUEJUN KARL
权利人:VISTAGEN THERAPEUTICS INC
摘要:The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermediates in the synthesis of L-4-chlorokynurenine.

专利号:US-8461357-B2
优先权日:2008-09-19
标题 :Expeditious synthesis of gibberellin A5 and esters thereof
发明人：FAIRWEATHER KELLY A; MANDER LEWIS N; PHARIS RICHARD P
权利人:FAIRWEATHER KELLY A; MANDER LEWIS N; PHARIS R P; UTI LIMITED PARTNERSHIP
摘要:An expeditious synthesis of gibberellin A 5 (GA 5 ) esters is presented, from which GA 5 may be prepared. The synthesis offers an inexpensive route of few steps to these compounds, starting from gibberellin A 3 (GA 3 ) esters in the presence of a metal hydride.

专利号:US-4287123-A
优先权日:1980-01-14
标题 :Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R is a readily removable carboxyl protecting group; and is a readily removable acyl group.

专利号:US-4282148-A
优先权日:1980-01-14
标 题:Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

专利号:US-4414155-A
优先权日:1980-01-14
标题 :Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
发明人：LIU THOMAS M H; MELILLO DAVID G; RYAN KENNETH M; SHINKAI ICHIRO; SLETZINGER MEYER
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R3 is a readily removable carboxyl protecting group.

专利号:US-4269772-A
优先权日:1980-01-14
标 题 :Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline
发明人：MELILLO DAVID G; RYAN KENNETH M
权利人:MERCK & CO INC
摘要:Disclosed is a process for the stereocontrolled total synthesis of thienamycin, which synthesis proceeds via intermediate II: II wherein R5 and R6 are removable protecting groups.