CAS: 126456-43-7; (1S,2R)-1-Amino-2,3-Dihydro-1H-Inden-2-Ol

上下游产品

3,3α,8,8α-tetrahydro-2H-indeno[1,2-d]oxazol-2-one oxazole2-phenyl-3a,8a-dihydro-8(H)-indeno1,2-doxazole 2,3-dihydro-1H-indene 2,3-oxide cis-indane-1,2-diol [(R)-1-((1S,2R)-2-Hydroxy-indan-1-ylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester [(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-((1S,2R)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-carbamic acid tert-butyl ester [(1S,2S,4R)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-((1R,2S)-2-hydroxy-indan-1-ylcarbamoyl)-5-phenyl-pentyl]-carbamic acid tert-butyl ester (1R,2S)-1-Amino-2-indanol

2-氧代茚满-1-甲酸甲酯置于氢氧化钾,Sodium Hydroxide,氯化亚砜,二苯基膦叠氮化物,三乙胺体系中,用 乙醇,水 用作溶剂,化学反应 73.0H,反应生成(1S,2R)-(-)-1-氨基-2-茚醇
参考文献:化学酶促合成1,2-和1,3-氨基醇及其在用硼烷对映选择性还原苯乙酮和抗苯乙酮肟甲基醚中的用途.
标题:化学酶促合成1,2-和1,3-氨基醇及其在用硼烷对映选择性还原苯乙酮和抗苯乙酮肟甲基醚中的用途.
摘要:以生物转化为关键步骤,对映选择性地合成了新的手性氨基醇.它们用作苯乙酮和相应的抗肟甲基醚的对映选择性硼烷还原中的配体.
Doi:10.1016/s0040-4020(01)80959-5

专利信息

专利号:US-2023278959-A1
优先权日:2020-05-04
标题:Synthesis of Optically Active Indoline Derivatives Via Ruthenium(II)-Catalyzed Enantioselective C-H Functionalization
发明人：CUI XIN; LI ZHONG-YUAN; CHAMINDA LAKMAL HETTI HANDI
权利人:UNIV MISSISSIPPI STATE
摘要:Provided herein are a method of Ru(II)-catalyzed enantioselective synthesis of a cyclic compound and cyclic compounds formed therefrom. The method includes providing a precursor compound having an unfunctionalized C—H bond and activating the unfunctionalized C—H bond by reacting the precursor compound in the presence of co-catalysts including a Ru(II) arene complex and a chiral transient directing group (CTDG).

专利号:US-7179919-B2
优先权日:2004-03-18
标 题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：SONG JINHUA J; TAN ZHULIN; YEE NATHAN K; SENANAYAKE CHRIS HUGH; XU JINGHUA; GALLOU FABRICE
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are as described herein.

专利号:EP-1730108-B1
优先权日:2004-03-18
标 题:Stereoselective synthesis of vitamin d analogues
发明人：SABROE THOMAS PETER; CALVERLEY MARTIN JOHN
权利人:LEO PHARMA AS
摘要:The present invention relates to intermediates useful for the synthesis of calcipotriol or calcipotriol monohydrate, to methods of producing said intermediates, and to methods of stereoselectively reducing said intermediates.

专利号:EP-1735276-B1
优先权日:2004-04-02
标题:Novel method for the preparation of intermediates useful for the synthesis of vitamin d analogues
发明人：HANSEN ERIK TORNGAARD; SABROE THOMAS PETER; CALVERLEY MARTIN JOHN; PEDERSEN HENRIK; DEUSSEN HEINZ-JOSEF WILHELM
权利人:LEO PHARMA AS
摘要:The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.

专利号:EP-2280974-B1
优先权日:2008-04-30
标题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：REEVES JONATHAN TIMOTHY; SONG JINHUA J; TAN ZHULIN
权利人:BOEHRINGER INGELHEIM INT; BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein.

专利号:US-6600040-B2
优先权日:2000-06-08
标 题:Process for the synthesis of (2R, 2-alpha-R, 3A)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1, 4-oxazine
发明人：BRANDS KAREL M JOS; TSAY FUH-RONG; CONRAD KAREN M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.