CAS: 122839-51-4; (R)-2-Amino-3-(2-Fluorophenyl)Propanoic Acid Hydrochloride

该化合物是一种合成氨基酸衍生物,其特征是苯丙烯结构的第二位置存在氟原子.作为盐盐,水中通常比其自由基质形式更容易溶解,这提高了其在各种生化应用中的效用.该化合物保留苯丙胺的基本特性,包括其作为蛋白质建筑块的作用及其参与...

英文名称(R)-2-Amino-3-(2-Fluorophenyl)Propanoic Acid Hydrochloride
中文名称(R)-2-氨基-3-(2-氟苯基)丙酸盐酸盐
其它别名(R)2AMINO3(2'FLUOROPHENYL)PROPANOICACID; (R)2AMINO3(2FLUOROPHENYL)PROPIONICACID; D2FLUOROPHE; D2FLUOROPHENYLALANINE; HOFLUORODPHEOH; HDPHE(OF)OH
CAS编号122839-51-4
MFCD编号:MFCD00066447
分子式:C9H11ClFNO2分子量:219.64
产品CID: 330178
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: NYCRCTMDYITATC-MRVPVSSYSA-N
1S/C9H10FNO2.ClH/c10-7-4-2-1-3-6(7)5-8(11)9(12)13;/h1-4,8H,5,11H2,(H,12,13);1H/t8-;/m1./s1
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数3.0

相似化合物

97731-02-7 114873-00-6 114873-10-8

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
安全声明22-24/25
WGK Germany3

上下游产品

(R)-2-fluoro-N-benzoyl-phenylalanine (Z)-2-Benzoylamino-3-(2-fluoro-phenyl)-acrylic acid

合成工艺路线路线简述

📜(Z)-2-Benzoylamino-3-(2-Fluoro-Phenyl)-Acrylic Acid置于盐酸,Cationic Rhodium Complex With (+)-(S)-"Propraphos",氢气体系中,用甲醇用作溶剂,25.0 °C,100.0 Kpa 条件下,反应 8.0H,反应生成D-2-氟苯丙氨酸
参考文献:Unusual Amino Acids
标题:Unusual Amino Acids
摘要:Few (Z)-Alpha-N-Benzoylamino-Beta-(Fluorophenyl)-Acrylic Acids And Their Esters Were Prepared By Known Procedures And Hydrogenated To The Corresponding Optically Active Alpha-Benzoyl-Beta-(Fluorophenyl)-Alanine Derivatives With Optical Yields Up To 90% Using The Rhodium Complexes Of "Propraphos" And O,N-Bis(Diphenylphosphino)-2-Exo-Hydroxy,3-Endo-Methylamino-Norbornane As Chiral Catalysts. The Method Proved To Be Apt For Upscaling The Preparation. Deacylation Of The Obtained Amino Acids Gave The Hydrochlorides Of The Fluorinated Phenylalanines In Very Pure State.
Doi:10.1016/s0957-4166(00)80262-1