CAS: 1080-12-2; 4-(4-Hydroxy-3-Methoxyphenyl)But-3-En-2-One

上下游产品

vanillin acetone 1-triphenylphosphoranylidene-2-propanone 4-(4-((tert-butyldimethylsiloxy)-methyl)-3-methoxyphenyl)-but-3-ene-2-one 4-hydroxy-3-[1-(4-hydroxy-3-methoxy-phenyl)-3-oxo-butyl]-coumarin t-(4-hydroxy-3-methoxy-phenyl)-1-methyl-allylidenehydrazide]isonicotinic acid-[3t-(4-hydroxy-3-methoxy-phenyl)-1-methyl-allylidenehydrazide] t-(4-hydroxy-3-methoxy-phenyl)-5-piperidino-pent-1-en-3-one; hydr°Chloride1t-(4-hydroxy-3-methoxy-phenyl)-5-piperidino-pent-1-en-3-one; hydr°Chloride vanillin

姜酮置于4-Ethylphenol Oxidase From Gulosibacter Chungangensis体系中,用 Aq. Phosphate Buffer,二甲基亚砜 用作溶剂,化学反应 24.0H,反应生成香草醛缩丙酮
参考文献:中港古洛酸杆菌 4-乙基酚氧化酶的发现,生物催化探索和结构分析
标题:中港古洛酸杆菌 4-乙基酚氧化酶的发现,生物催化探索和结构分析
摘要:Gc4Eo是来自放线菌gulosibacter Chungangensis的vao/pcmh家族的新成员.这种氧化酶是一种非常有吸引力的 4-烷基酚氧化生物催化剂,具有高转化率和对烯烃生产具有吸引力的化学选择性. Gc4Eo 显示出高活性,可以产生 4-乙烯基苯酚,这是合成聚乙烯苯酚的一个有趣的结构单元.
Doi:10.1002/cbic.202100457

专利信息

专利号:US-11746364-B2
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains
发明人：PLUSKAL TOMÃ?S; Weng jing-ke
权利人:WHITEHEAD INST BIOMEDICAL RES
摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

专利号:US-8309742-B2
优先权日:2007-05-09
标题 :Use of the PigD protein for catalyzing 1,4-additions of 2-oxoalkanoates to α, β-unsaturated ketones
发明人：MUELLER MICHAEL; DRESEN CAROLA; RICHTER MICHAEL
权利人:MUELLER MICHAEL; DRESEN CAROLA; RICHTER MICHAEL; UNIV ALBERT LUDWIGS FREIBURG
摘要:The present invention relates to the preparation of compounds of the general formula II which can be obtained by 1,4 addition of 2-oxoalkanoates or 2-oxocarboxylic acids onto the appropriate ketones. The present invention also relates to the use of the PigD protein for catalysis of 1,4 additions of 2-oxoalkanoates/-carboxylic acids, for example pyruvate/pyruvic acid or 2-oxobutyrate/2-oxobutyric acid, onto aliphatic, aromatic and heterocyclic α,β-unsaturated ketones. The 1,4 additions are effected here with CO2 elimination. The use of the PigD protein as a catalyst in the aforementioned 1,4 additions enables the synthesis of addition products with stereoactive centers these addition products being preparable with an enantiomeric excess of more than 80% ee. The aliphatic, aromatic and heterocyclic α,β-unsaturated ketones which are suitable for the process are represented by the general formula I:

专利号:EP-2436673-A1
优先权日:2010-09-30
标 题:Curcumin derivatives with improved physicochemical properties and nanoliposomes surface-decorated with the derivatives with very high affinity for amyloid-beta1-42 peptide
发明人：ANTIMISIARI SOPHIA; MOURTAS SPIRIDON; NIARAKI ANNA; ZONA CRISTIANO; MASSERINI MASSIMO; NICOTRA FRANCESCO; LA FERLA BARBARA
权利人:NIARAKI ANNA; UNIV PATRAS; UNIV MILANO BICOCCA; ANTIMISIARI SOFIA; MOURTAS SPIRIDON
摘要:Amyloid β (Aβ) aggregates are considered as possible targets for therapy and/or diagnosis of Alzheimer disease (AD). It has been previously shown that curcumin targets Aβ plaques and interferes with their formation, suggesting a potential role for prevention or treatment of AD. In the present invention, curcumin-derivatives with improved physicochemical properties were synthesized and a 'click chemistry' as well as a conventional liposome preparation method, were used to generate nanoliposomes decorated with the curcumin derivatives. These derivatives were designed to maintain the planar structure required for interaction with Aβ, as directly confirmed by Surface Plasmon Resonance experiments. Surface Plasmon Resonance experiments, measuring the binding of flowing liposomes to immobilized Aβ1-42, indicated that the liposomes exposing curcumin derivatives have extremely high affinity for Aβ1-42 fibrils (1-5 nM), likely because of the occurrence of multivalent interactions. The present invention describes the synthesis of the curcumin derivatives and the preparation and characterization of new nanoliposomes with a very high affinity for Aβ1-42 fibrils, to be exploited as vectors for the targeted delivery of new diagnostic and therapeutic molecules for AD.

专利号:JP-6490927-B2
优先权日:2014-07-01
标题 :Synthesis of Calebin A and Its Biologically Active Analogues

专利号:CA-2858126-A1
优先权日:2014-07-01
标 题 :Synthesis of calebin-a and its biologically active analogs

专利号:US-9365486-B2
优先权日:2014-07-01
标 题:Synthesis of calebin-A and its biologically active analogs
发明人：MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MAJEED ANJU; THOMAS SAMUEL MANOHARAN
权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MAJEED ANJU; THOMAS SAMUEL MANOHARAN
摘要:Disclosed is a simple, economical, industrially scalable green synthetic process for Calebin-A and its biologically active analogs.