CAS: 10294-66-3; Potassium Thiosulfate

专利信息

专利号:US-11040938-B2
优先权日:2016-07-27
标 题 :Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
发明人：MA BING; PAN SHUAI
权利人:SHANGHAI HYBRID—CHEM TECH; SHANGHAI HYBRID CHEM TECH
摘要:The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

专利号:US-6455680-B1
优先权日:2000-12-21
标 题 :Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
发明人：LUKIN KIRILL A
权利人:ABBOTT LAB
摘要:An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.

专利号:US-11795076-B2
优先权日:2020-04-29
标题:Synthesis method of indole derivative capable of efficiently degrading perfluorinated compound (PFC)
发明人：JIN XIN; GU CHENG
权利人:NANJING UNIVERSITY OF TECHNOLOGY
摘要:A synthesis method of an indole derivative capable of efficiently degrading a perfluorinated compound (PFC) and a use of the indole derivative are provided. The synthesis method includes dissolving an appropriate amount of indole, alkylamine, and formaldehyde in an ethanol solution, conducting a reaction at reflux under suitable conditions for a specified period of time with ZnCl 2 or glacial acetic acid as a catalyst to form a reaction product, vacuum-drying the reaction product, and purifying the reaction product through column chromatography to obtain a novel indole derivative with a hydrophobic alkyl branch. The present indole derivative has some hydrophobicity and a positively charged amino group that can effectively capture PFCs in contaminated water to produce a sub-nanoscale self-assembled aggregate. Hydrated electrons generated by light irradiation can directly attack PFCs in the aggregate without long-distance mass transfer, improving the utilization rate of hydrated electrons and reduces the ratio of fed materials.

专利号:US-5670465-A
优先权日:1993-01-08
标题 :Preparation of p-fuchsones and synthesis of p-dihydroxylated aromatic compounds therefrom
发明人：COSTANTINI MICHEL; MANAUT DANIEL; MICHELET DANIEL
权利人:RHONE POULENC CHIMIE
摘要:p-Dihydroxylated aromatic compounds are prepared via the oxidation of p-fuchsones, the latter advantageously being synthesized by reacting a phenolic compound having at least one hydrogen atom in the para-position to the hydroxyl function with a non-enolizable ketonic compound, in the presence of a catalytically effective amount of an acid catalyst and, optionally, a cocatalytically effective amount of an ionizable sulfur-containing compound.

专利号:WO-2024209478-A1
优先权日:2023-04-07
标题:Synthesis of cyclic ketone from cyclic amino acid
发明人：BICIDI JAYAPAL REDDY; RAMIYA RAJARAM AMARESH; PILLAI BIJUKUMAR GOPINATHAN
权利人:ADAMA MAKHTESHIM LTD
摘要:A process for preparation of a compound of formula (I) in which R is hydrogen, hydroxyl, C1-C10 -alkyl, C1-C10 -alkoxy, C1-C4 -alkylamino, di- C1-C4 - alkylamino, C1-C4 -acylamino, COOR1, — CH2— R2 where R1 is hydrogen or C1-C4 -alkyl or R2—CH2— and R2 is hydroxyl, C1-C4 -alkoxy, C1-C4 -alkylamino or di- C1-C4 -alkylamino; n represents the number of carbon atoms and is any integer of 0, 1, 2; and m represents the number of R groups and satisfies the relation: 0≤m≤8+2n. The process comprising: (a) oxidation of a compound of formula (III) wherein R is as defined above, with salt of a hypohalous acid to give compound of the formula (II), wherein R, n and m are as defined above, and X is Cl, Br or I; and (b) hydrolysis in the presence of water of the compound of the formula (II).

专利号:US-9422260-B2
优先权日:2009-09-18
标 题 :Process for the synthesis of 4,5,6,7-tetrachloro-3′,6′-dihydroxy-2′,4′,5′,7′-tetraiodo-3H-spiro[isobenzofuran-1,9′-xanthen]-3-one(Rose Bengal) and related xanthenes
发明人：SINGER JAMIE; WACHTER ERIC A; SCOTT TIMOTHY; LUTZ MARLON; BABIAK KEVIN
权利人:PROVECTUS PHARMACEUTICALS INC; PROVECTUS PHARMATECH INC
摘要:A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100° C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments.