CAS: 102-76-1; Propane-1,2,3-Triyl Triacetate

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623-39-2 623-69-8 56-81-5

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CAS号108-24-7 乙酸酐 | CAS号56-81-5 甘油 | CAS号64-19-7 冰醋酸 | CAS号75-36-5 乙酰氯 | CAS号1708-40-3 2-苯基-1,3-二氧六环-5-醇 | CAS号556-52-5 缩水甘油 | CAS号57-55-6 丙二醇 | CAS号7631-86-9 单分散二氧化硅微球 | CAS号144875-48-9 雷西莫特 | CAS号473-90-5 中草酸 | CAS号555-43-1 三硬脂酸甘油酯 | CAS号3724-65-0 巴豆酸 | CAS号556-56-9 烯丙基碘 | CAS号625-38-7 乙烯基乙酸 | CAS号591-87-7 乙酸烯丙酯 | CAS号79-31-2 异丁酸 | CAS号107-92-6 正丁酸 | CAS号75-30-9 2-碘代丙烷 | CAS号108-21-4 醋酸异丙酯

1,2,3-Triacetoxy-2-Pivaloylpropane置于叔丁基硫醇体系中,用 甲苯 用作溶剂,以93%的收率获得三醋精
参考文献:C-2 甘油基化学:脂质损伤新机制的适应症
标题:C-2 甘油基化学:脂质损伤新机制的适应症
摘要:合成了选择性反应生成C-2 甘油自由基的前体,并通过 Esr 光谱,产物分析和动力学测量研究了相应自由基的化学行为.发现如果羟基存在于自由基碳中心,β-C,O 键的断裂会迅速进行.从自由基 30 中消除 β-乙酰氧基的速率常数取决于溶剂(甲醇中 Ke = 4 x 105 S-1,甲苯中 Ke = 2 x 107 S-1).根据这些结果和从头计算,建议使用协同消除机制.α-甲氧基取代的 C-2 甘油基 42 和 43 在自由基阳离子的形成下表现出异裂 β-C,O 键裂解.对于酯取代的基团 24 和 35,没有观测到消除.
Doi:10.1021/ja9641416

专利信息

专利号:WO-9104337-A1
优先权日:1989-09-25
标题 :ENANTIOSELECTIVE, ENZYMATIC SYNTHESIS OF S(-) and R(+) ESTERS OF 4-HYDROXY-CYCLOPENTENE-1-ONE AND ITS 2',2'-DIMETHYLPROPANE-1',3'-DIOL-KETAL
发明人：SCHAPOEHLER STEFAN B; SCHEPER THOMAS; SCHUEGERL KARL
权利人:EUROP COMMUNITIES
摘要:The S(-) and R(+) esters of 4-hydroxy-cyclopentene-1-one and its 2',2'-dimethylpropane 1',3'-diol-ketal are produced by direct, enantioselective, enzymatic synthesis by reacting the corresponding 4-hydroxy compounds with an ester as acyl donor in the presence of an enzyme. The esters obtained are valuable intermediate products for stereospecific synthesis, in particular for the stereoselective synthesis of chemical compounds, in particular stable, storable, chiral prostaglandin derivatives, especially storable chiral prostaglandinsynthone.

专利号:US-2015057366-A1
优先权日:2012-03-05
标题 :Synthesis of elemicin and topical analgesic compositions
发明人：LA GRANGE MARTIN JAMES
权利人:LA GRANGE MARTIN JAMES
摘要:The present invention is directed to the synthesis of elemicin and its isomeric form, and their use in topical analgesic formulations, including for dental and veterinary use. Various compositions include gels, films, dressings, cavity filling gels, having analgesic and/or antifungal properties.

专利号:US-7605241-B2
优先权日:2005-01-10
标题 :Synthesis of inhibitors of p90Rsk
发明人：HECHT SIDNEY M; MALONEY DAVID J
权利人:UNIV VIRGINIA
摘要:The synthesis of the naturally occurring kaempferol glycoside SLO1O1-1, as well as analogs thereof, has been accomplished, as has its biochemical evaluation. SLO1O1-1 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthetic scheme of the invention verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.

专利号:US-2010261876-A1
优先权日:2007-09-25
标 题:Novel methods of synthesis for therapeutic antiviral peptides
发明人：BRAY BRIAN L; JOHNSTON BARBARA E; SCHNEIDER STEPHEN E; TVERMOES NICOLAI A; ZHANG HUYI; FRIEDRICH PAUL E
权利人:BRAY BRIAN L; JOHNSTON BARBARA E; SCHNEIDER STEPHEN E; TVERMOES NICOLAI A; ZHANG HUYI; FRIEDRICH PAUL E
摘要:Provided herein are methods for synthesis of peptides. In particular, provided herein are methods of synthesis for therapeutic antiviral peptides.

专利号:US-8557979-B2
优先权日:2004-06-10
标题 :Carbapenem antibacterials with gram-negative activity and processes for their preparation
发明人：CHOI WOO-BAEG; KOWALIK EWA
权利人:CHOI WOO-BAEG; KOWALIK EWA; FOB SYNTHESIS INC
摘要:The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

专利号:US-6869973-B2
优先权日:2000-06-22
标题:Nitrosated and nitrosylated taxanes, compositions and methods of use
发明人：GARVEY DAVID S; LETTS L GORDON; LIN CHIA-EN; RICHARDSON STEWART K; WANG TIANSHENG
权利人:NITROMED INC
摘要:The present invention describes novel nitrosated and/or nitrosylated taxanes, and novel compositions comprising at least one nitrosated and/or nitrosylated taxane, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The present invention also provides novel compositions comprising at least one taxane and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The compounds and compositions of the present invention can also be bound to a matrix. The present invention also provides methods for treating or preventing cardiovascular diseases and disorders, autoimmune diseases, pathological conditions resulting from abnormal cell proliferation, polycystic kidney disease, inflammatory disease, preserving organs and/or tissues or to inhibit wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis, by administering nitrosated and/or nitrosylated taxane or parent taxanes in combination with nitric oxide donors that are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions.