CAS: 10138-99-5; (S)-2-Amino-3-(Dimethylamino)Propanoic Acid

该化合物是一种手性非蛋白性氨基酸,在β位置上有一个二甲基氨基酸组,其结构独特性,将氨基酸脊柱与三级探雷功能相结合,在有机合成和制药研究中具有价值,该化合物是用于消毒和生物活性分子设计的多功能建筑块,能够调节溶性和基本性等物理化学特性.

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31697-39-9 94778-71-9 587880-86-2

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    CAS号506-59-2 盐酸二甲胺

    合成工艺路线路线简述

      📜N-Benzyloxycarbonyl-(S)-2-Amino-3-(Dimethylamino)Propanoic Acid置于palladium 10% On Activated Carbon,氢气体系中,用 甲醇 用作溶剂,以96.3 %的收率获得3-(N,N-二甲基氨基)-L-丙氨酸
      参考文献: Compounds As Immunomodulators Of Pd-L1 Interactions[fr] Composés à Utiliser En Tant Qu'Immunomodulateurs D'Interactions Pd-L1
      标题: Compounds As Immunomodulators Of Pd-L1 Interactions[fr] Composés à Utiliser En Tant Qu'Immunomodulateurs D'Interactions Pd-L1
      摘要:Pd-L1 Inhibitors Of Various Compound Formulas,Both Generically And Specifically Are Disclosed. Methods Of Making Such Pd-L1 Inhibitor Compounds Are Disclosed,Both Generically And Specifically. Methods Of Using Such Pd-L1 Inhibitor Compounds Singly Or In Combination With Additional Agents And Compositions Of Such Pd-L1 Inhibitor Compounds For The Treatment Of Cancer And Other Conditions Are Disclosed.

      海关参考信息

      专利信息


      专利号:US-2020354404-A1
      优先权日:2019-05-09
      标 题 :Peptidomimetic agents, synthesis and uses thereof
      发明人:AL-ABED YOUSEF
      权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
      摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

      专利号:US-2023037284-A9
      优先权日:2018-11-30
      标题:Combination therapy of peptidomimetic macrocycles
      发明人:GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
      权利人:AILERON THERAPEUTICS INC
      摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

      专利号:US-2025084410-A1
      优先权日:2015-01-12
      标 题:Incorporation of unnatural nucleotides and methods thereof
      发明人:PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
      权利人:SYNTHORX INC
      摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

      专利号:US-2018371021-A1
      优先权日:2017-05-11
      标 题 :Peptidomimetic macrocycles and uses thereof
      发明人:AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
      权利人:AILERON THERAPEUTICS INC
      摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

      专利号:US-10919882-B2
      优先权日:2019-05-09
      标题:Compounds for use in synthesis of peptidomimetics

      专利号:CN-115515937-A
      优先权日:2020-05-08
      标 题:Dimers for the synthesis of peptidomimetics

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      ✅ COA系统入驻 | 共享模式

      主要参考文献

      参考标题:Asymmetric Synthesis Of β-Substituted α-Amino Acids Via A Chiral Nlii Complex Of Dehydroalanine
      作者:Yuri N. Belokon',Ashot S. Sagyan,Silva M. Djamgaryan,Vladimir I. Bakhmutov,Vasili M. Belikov |发布日期:1988.1

      合成参考文献


      摘要:CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980, 4(1)(51), 1980
      参考文献:10.1186/1471-2180-10-35
      摘要:Han X, Dorsey-Oresto A, Malik M, Wang JY, Drlica K, Zhao X, Lu T. Escherichia coli genes that reduce the lethal effects of stress. BMC Microbiol. 2010 Feb 04;10():35.
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