CAS: 932-62-7; 3-Acetyl-1-Methylpyrrole

该化合物是一种环环状有机化合物,其特点是以乙酰和甲基功能组取代了火花环,该化合物因其在有机合成中,特别是在制药,农用化学品和特殊化学品的生产中作为多种中间体的作用而备受重视.该化合物的乙酰混合物组增强了反应性,使其在凝聚和循环反应中有用.甲基替代品提高了有机溶剂的稳定性和溶性,便利了处理和净化.其结构特性也使它成为物质科学应用的候选产品,例如导体聚合物的开发.该化合物的明确界定的再活性特征确保了合成工艺的再生性.

结构式图片

相似化合物

36929-60-9 1072-82-8 126624-55-3

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

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CAS号1072-82-8 3-乙酰基吡咯 | CAS号74-83-9 溴甲烷 | CAS号4229-44-1 N-甲基羟胺盐酸盐 | CAS号75-36-5 乙酰氯 | CAS号762-42-5 丁炔二酸二甲酯 | CAS号75866-91-0 1H-Pyrrole-2-ca... | CAS号96-54-8 N-甲基吡咯 | CAS号932-16-1 N-甲基-2-乙酰基吡咯 | CAS号108-24-7 乙酸酐 | CAS号126624-55-3 2-氯-1-(1-甲基-1H-...

合成工艺路线路线简述

  • 37181-39-8 = 932-62-7
    反应条件:1.1 Reagents: Tert-Butylbenzene,Water-D2 Solvents: Acetonitrile-D3
    标题:β-Electrophilic Additions Of Pentaammineosmium(Ii) η2-Pyrrole Complexes
    作者:Hodges,L. Mark; Gonzalez,Javier; Koontz,Jason I.; Myers,William H.; Harman,W. Dean
    参考文献:Journal Of Organic Chemistry 日期:1995 卷标:60(7) 页码:2125-46]

    1786460-97-6 = 932-62-7
    反应条件:1.1 Reagents: Sodium Acetate Solvents: Water; 15 Min,Reflux
    标题:Reactions Of Nitrilium Salts With Indole And Pyrrole And Their Derivatives In The Synthesis Of Imines,Ketones And Secondary Amines
    作者:Giles,Robert G.; Heaney,Harry; Plater,M. John
    参考文献:Tetrahedron 日期:2015 卷标:71(39) 页码:7367-7385]

    932-16-1 = 932-62-7
    反应条件:1.1 Catalysts: Trifluoroacetic Acid
    标题:Acid-Mediated Rearrangement Of Acylpyrroles
    作者:Carson,John R.; Davis,Nancy M.
    参考文献:Journal Of Organic Chemistry 日期:1981 卷标:46(5) 页码:839-43]

    = 932-62-7 [标题:Reaction Conditions
    标题:Photoaddition Of β-Dicarbonyl Compounds To Nitrogen Heterocycles
    作者:Pavlik,James W.; Farahat,Mohammad S.
    参考文献:Bulletin Of The Chemical Society Of Ethiopia 日期:1988 卷标:2(2) 页码:61-7]

    = 932-62-7 [标题:Reaction Conditions
    标题:Furfurylthioacetone
    参考文献:United States]

    = 932-62-7 [标题:Reaction Conditions
    标题:Flavoring Additives
    参考文献:United States]

    = 932-62-7 [标题:Reaction Conditions
    标题:2,5-Dimethyl-3-Thiopyrazines
    参考文献:United States]

    58569-87-2 + 96-54-8 = 932-62-7 + 932-16-1
    反应条件:1.1 Solvents: Chloroform; 0 °C; 156 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Neutralized,0 °C
    标题:Photo-On-Demand Synthesis Of Vilsmeier Reagents With Chloroform And Their Applications To One-Pot Organic Syntheses
    作者:Liang,Fengying; Eda,Kazuo; Okazoe,Takashi; Wada,Akihiro; Mori,Nobuaki; Et Al
    参考文献:Journal Of Organic Chemistry 日期:2021 卷标:86(9) 页码:6504-6517]

    762-42-5 + 4229-44-1 = 932-62-7
    反应条件:1.1 Reagents: Potassium Bicarbonate Solvents: Dichloromethane; 15 Min,Rt1.2 Solvents: Dichloromethane; 40 °C; 3 H,40 °C
    标题:A Mild And Facile One-Pot Synthesis Of N-Methyl-3-(Acyl)Pyrroles
    作者:Valizadeh,Hassan; Fakhari,Ashraf
    参考文献:Molecules 日期:2010 卷标:15 页码:2972-2979]

    75866-91-0 = 932-62-7 [标题:Reaction Conditions
    标题:Pyrrole Chemistry. Xxii. A "One-Pot" Synthesis Of Some 4-Acylpyrrole-2-Carboxaldehydes From Pyrrole
    作者:Anderson,Hugh J.; Loader,Charles E.; Foster,Aidan
    参考文献:Canadian Journal Of Chemistry 日期:1980 卷标:58(23) 页码:2527-30]

    1072-82-8 = 932-62-7
    反应条件:1.1 Reagents: Potassium Carbonate Catalysts: Tetrabutylammonium Bromide Solvents: Methyl Ethyl Ketone
    标题:Selective α-Chlorination Of Acetylpyrroles
    作者:Dalla Croce,Piero; Ferraccioli,Raffaella; Ritieni,Alberto
    参考文献:Synthesis 日期:1990 卷标:(3) 页码:212-13]

    1072-82-8 = 932-62-7
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran; 0.5 H,0 °C1.2 0 °C -> Rt
    标题:Synthesis Of Tetrahydroindolones And Tetrahydrocarbazolones Via Palladium Catalyzed C-H Activation
    作者:Zhang,Tiantian; Xu,Hongjin; Song,Chuanjun; Chang,Junbiao
    参考文献:Tetrahedron Letters 日期:2018 卷标:59(52) 页码:4562-4565]

    70702-65-7 = 932-62-7
    反应条件:1.1 Reagents: Manganese Oxide (Mno2) Solvents: Dichloromethane
    标题:Regioselective Photoaddition Of Pyrroles And Aliphatic Carbonyl Compounds. A New Synthesis Of 3(4)-Substituted Pyrroles
    作者:Jones,Guilford Ii; Gilow,Helmuth M.; Low,Julie
    参考文献:Journal Of Organic Chemistry 日期:1979 卷标:44(16) 页码:2949-51]

    = 932-62-7 [标题:Reaction Conditions
    标题:Method For Preparing N-Alkyl-2-Methyl-5-Formyl-3-Pyrrole Formate And Application In Flavoring Cigarette
    参考文献:China]

    = 932-62-7 [标题:Reaction Conditions
    标题:β-Acylpyrroles
    参考文献:Federal Republic Of Germany]

    = 932-62-7 [标题:Reaction Conditions
    标题:β-Acyl Pyrroles
    参考文献:United States]

    = 932-62-7 [标题:Reaction Conditions
    标题:Pyrrylmethylthio Flavoring Agents
    参考文献:United States]

    = 932-62-7 [标题:Reaction Conditions
    标题:Flavoring Agent
    参考文献:United States]

    = 932-62-7 [标题:Reaction Conditions
    标题:Flavoring Agents
    参考文献:United States
📜2-乙酰基-1-甲基吡咯置于三氟乙酸体系中,化学反应 1.5H,以80%的收率获得产物3-乙酰基-1-甲基吡咯
参考文献:Acid-Mediated Rearrangement Of Acylpyrroles
标题:Acid-Mediated Rearrangement Of Acylpyrroles
摘要:
DOI:10.1021/jo00318A002

海关参考信息

专利信息


专利号:WO-2024064745-A1
优先权日:2022-09-21
标 题:Synthesis of reldesemtiv
发明人：PETERSON MATTHEW W; LU QING; MORGAN BRADLEY P; ASHCRAFT LUKE W; ANDERSEN DENISE
权利人:CYTOKINETICS INC
摘要:Provided herein is a process for the preparation of reldesemtiv and salts thereof. Also provided herein are intermediates used in this process and their preparation.

专利号:US-5059709-A
优先权日:1990-11-13
标题 :Process for the synthesis of α-[(dialkylamino)substituted-methylene]-β-oxo-(substituted)propanentriles
发明人：DUSZA JOHN P; CHURCH ROBERT F
权利人:AMERICAN CYANAMID CO
摘要:A novel process for producing α-[(dialkylamino) substituted-methylene]β-oxo-(substituted) propanenitriles of the formula: ##STR1## where R, R 1 and R 2 are defined in the specification by reacting a substituted isoxazole with a diaklylamide dimethylacetal is provided.

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主要参考文献

参考标题:Platinum-Catalyzed Domino Reaction With Benziodoxole Reagents For Accessing Benzene-Alkynylated Indoles
作者:Yifan Li,Jerome Waser |发布日期:2015.4.27
摘要:Platinum‐catalyzed Cyclization/alkynylation Domino Process To Selectively Obtain C5‐ Or C6‐functionalized Indoles Starting From Easily Available Pyrroles. The Work Combines, For The First Time, A Platinum Catalyst With Ethynylbenziodoxole Hypervalent Iodine Reagents In A Domino Process For The Synthesis Of Polyfunctionalized Arene Rings And Gives Access To Important Building Blocks For The Synthesis Of Bioactive

合成参考文献


摘要:Lubell, W. D.; St-Cyr, D. J.; Dufour-Gallant, J.; Hopewell, R.; Boutard, N.; Kassem, T.; Dörr, A.; Zelli, R., Science of Synthesis Knowledge Updates, (2013) 1, 303.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 200.
摘要:Chan, W.-W.; Yu, W.-Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 108.
摘要:Ruan, Z.; Huang, Z.; Kuciński, K.; Ackermann, L., Science of Synthesis: Special Topics, (2021) 1, 237.
摘要:Solorio-Alvarado, C. R., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .
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