CAS: 88150-42-9; 3-Ethyl 5-Methyl 2-((2-Aminoethoxy)Methyl)-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydropyridine-3,5-Dicarboxylate

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CAS号111470-99-6 苯磺酸氨氯地平 | CAS号88150-62-3 邻苯二甲酰基氨氯地平 | CAS号88150-46-3 3-O-ethyl 5-O-m... | CAS号638-07-3 4-氯乙酰乙酸乙酯 | CAS号88150-45-2 ETHYL (2-AZIDOE... | CAS号120289-15-8 2-(2-azidoethox... | CAS号88150-75-8 4-(2-邻苯二甲酰亚胺基乙氧... | CAS号88150-47-4 马来酸氨氯地平 | CAS号58-93-5 氢氯噻嗪 | CAS号111470-99-6 苯磺酸氨氯地平 | CAS号103129-82-4 苯磺酸左旋氨氯地平 | CAS号103129-81-3 氨氯地平

苯磺酸氨氯地平置于sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 1.0H,反应生成 氨氯地平
参考文献:两种经过验证的稳定性指示色谱方法,用于在降解产物或杂质存在的情况下分离两种抗高血压药
标题:两种经过验证的稳定性指示色谱方法,用于在降解产物或杂质存在的情况下分离两种抗高血压药
摘要:开发,优化和验证了两种rp-HPLC方法,用于在降解产物或杂质存在及其药物制剂中测定两种不同的抗高血压组合.第一种混合物是雷米普利(ram)和苯磺酸氨氯地平(aml)[混合物i],而第二种混合物是雷米普利(ram),阿托伐他汀(atv)和阿司匹林(asp)[混合物ii].提议的组合已在x桥c 18上成功分离色谱柱(250x4.6 Mm内径,5 µm Ps),使用0.05 M磷酸盐缓冲液-乙腈-Thf(60:40:0.1%体积)ph 2.5的流动相和由乙腈-0.05 M磷酸盐形成的等度流动相混合物(i)和(II)的缓冲液-Thf(60:40:0.1体积%)ph 2.5,流速分别为1 Ml / Min和1.2 Ml / Min.在218 Nm处检测到混合物中的有害成分.为了最好地分离上述组分,检查并优化了不同的参数.两种建议的方法均已按照ich指南进行了验证,并成功地用于存在的降解产物及其商业
DOI:10.1007/s11696-019-00792-Z

专利信息

专利号:US-9353057-B2
优先权日:2003-12-30
标 题:Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
发明人：GALLOP MARK A; DAI XUEDONG; SCHEUERMAN RANDALL A; RAILLARD STEPHEN P; MANTHATI SURESH K; YAO FENMEI; PHAN THU; LUDWIKOW MARIA; PENG GE; BHAT SEEMA
权利人:XENOPORT INC
摘要:Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

专利号:US-2025179012-A1
优先权日:2022-03-04
标 题:Synthesis of sulfur(vi) compounds and reagents for same
发明人：LOPCHUK JUSTIN MATTHEW; SHULTZ ZACHARY
权利人:H LEE MOFFITT CANCER CT & RES
摘要:This disclosure provides reagents and processes for the synthesis of organic compounds, more particularly reagents and processes for the asymmetric synthesis of sulfur (VI) containing organic compounds.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-10973847-B2
优先权日:2017-06-30
标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof
发明人：JOHNSON JEREMIAH A; GOLDER MATTHEW R
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-8445693-B2
优先权日:2008-03-20
标 题 :Catalyzed carbonylation in the synthesis of angiotensin II antagonists
发明人：CASAR ZDENKO; COPAR ANTON; CLUZEAU JEROME; PREMRL ANDREJ
权利人:CASAR ZDENKO; COPAR ANTON; CLUZEAU JEROME; PREMRL ANDREJ; LEK PHARMACEUTICALS
摘要:One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3′-(2′-halo-biphenyl-4-ylmethyl)-1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′]bibenzoimidazolyl (TLMH) using either gaseous carbon monoxide in a solvent mixture containing water; or formic acid salts optionally together with acetic acid in anhydrous solvent.