CAS: 86604-80-0; 4-Methoxy-2,3,5-Trimethylpyride-N-Oxide

该化合物是一种丙烯衍生物,其特征是N-氧化功能组和4位置的甲氧替代物,该化合物与非氧化对应物相比,溶性和回活性增强,在合成化学应用中具有价值,甲基组在2,3和5位置的存在有助于...

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CAS号109371-20-2 4-氯-2,3,5-三甲基吡啶... | CAS号86604-79-7 4-硝基-2,3,5-三甲基吡... | CAS号7722-84-1 过氧化氢 | CAS号109371-19-9 4-甲氧基-2,3,5-三甲基吡啶 | CAS号75-09-2 二氯甲烷 | CAS号74409-42-0 2,3,5-三甲基吡啶 N-氧化物 | CAS号124-41-4 甲醇钠 | CAS号109371-17-7 2,4-二氯-3,5,6-三甲基吡啶 | CAS号109371-16-6 2-hydroxy-3,5,6... | CAS号67-56-1 甲醇 | CAS号109371-19-9 4-甲氧基-2,3,5-三甲基吡啶 | CAS号86604-75-3 3,5-二甲基-2-氯甲基-4... | CAS号86604-78-6 奥美拉唑羟基物 | CAS号84006-10-0 2-氯甲基-3,5二甲基-4-... | CAS号73590-85-9 奥美拉唑硫醚 | CAS号73590-87-1 2-[(4-methoxy-3... | CAS号91219-90-8 2-(乙酰氧基甲基)-4-甲氧... | CAS号96300-88-8 3,5-二甲基-4-甲氧基-2-吡啶

合成工艺路线路线简述

  • 86604-79-7 = 86604-80-0
    反应条件:1.1 Reagents: Sodium Methoxide
    标题:Thiophene As A Structure Element In Pharmacologically Active Compounds
    作者:Rovenszky,Franz
    参考文献:1985]

    109371-19-9 = 86604-80-0
    反应条件:1.1 Reagents: Hydrogen Peroxide Solvents: Acetic Acid,Water
    标题:Synthesis Of 4-Methoxy-2,3,5-Trimethylpyridine: A Specific Building Block For Compounds With Gastric Acid-Inhibiting Activity
    作者:Mittelbach,Martin; Et Al
    参考文献:Acta Chemica Scandinavica 日期:1988 卷标:42(8) 页码:524-9]

    109371-20-2 = 86604-80-0 [标题:Reaction Conditions
    标题:Product Class 1: Pyridines
    作者:Spitzner,D.
    参考文献:Science Of Synthesis 日期:2005 卷标:15 页码:11-284]

    109371-18-8 = 86604-80-0
    反应条件:1.1 Reagents: Hydrogen Peroxide Solvents: Acetic Acid,Water2.1 Reagents: Sodium Methoxide Solvents: Methanol
    标题:Synthesis Of 4-Methoxy-2,3,5-Trimethylpyridine: A Specific Building Block For Compounds With Gastric Acid-Inhibiting Activity
    作者:Mittelbach,Martin; Et Al
    参考文献:Acta Chemica Scandinavica 日期:1988 卷标:42(8) 页码:524-9]

    86604-79-7 = 86604-80-0
    反应条件:1.1 Reagents: Tert-Butyl Hypochlorite Solvents: Ethanol; Rt; 3 H,75 °C2.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 2 H,95 °C2.2 Reagents: Hydrochloric Acid Solvents: Water; Neutralized
    标题:Image-Guided Development Of Heterocyclic Sulfoxides As Ligands For Tau Neurofibrillary Tangles: From First-In-Man To Second-Generation Ligands
    作者:Rafique,Waqas; Et Al
    参考文献:Acs Omega 日期:2018 卷标:3(7) 页码:7567-7579]

    86604-79-7 = 86604-80-0
    反应条件:1.1 Reagents: Phosphorus Oxychloride; 3 - 4 H,Reflux2.1 Reagents: Sodium Hydroxide
    标题:Diversified Synthesis Of Novel Quinoline And Dibenzothiazepine Derivatives Using Known Active Intermediates
    作者:Sharada,L. N.; Et Al
    参考文献:Asian Journal Of Chemistry 日期:2013 卷标:25(14) 页码:7959-7966]

    86604-79-7 = 86604-80-0
    反应条件:1.1 Reagents: Phosphorus Oxychloride; 3 - 4 H,Reflux2.1 Reagents: Sodium Hydroxide
    标题:Simple,Convergent Synthesis Of The Piperazine-Linked Pyridine Derivatives: Microwave,Sonication And Conventional Methods
    作者:Sharada,L. N.; Et Al
    参考文献:Journal Of Pharmacy Research (Gurgaon 日期:2013 卷标:7(1) 页码:107-112]

    109371-17-7 = 86604-80-0
    反应条件:1.1 Reagents: Hydrogen,Sulfuric Acid Catalysts: Palladium Solvents: Ethanol2.1 Reagents: Methanol,Potassium Hydroxide Solvents: Dimethyl Sulfoxide3.1 Reagents: Hydrogen Peroxide Solvents: Acetic Acid,Water
    标题:Synthesis Of 4-Methoxy-2,3,5-Trimethylpyridine: A Specific Building Block For Compounds With Gastric Acid-Inhibiting Activity
    作者:Mittelbach,Martin; Et Al
    参考文献:Acta Chemica Scandinavica 日期:1988 卷标:42(8) 页码:524-9]

    609-08-5 + 14369-90-5 = 86604-80-0
    反应条件:1.1 Reagents: Sodium Solvents: Ethanol,Toluene1.2 Solvents: Toluene2.1 Reagents: Phosphorus Oxychloride3.1 Reagents: Hydrogen,Sulfuric Acid Catalysts: Palladium Solvents: Ethanol4.1 Reagents: Hydrogen Peroxide Solvents: Acetic Acid,Water5.1 Reagents: Sodium Methoxide Solvents: Methanol
    标题:Synthesis Of 4-Methoxy-2,3,5-Trimethylpyridine: A Specific Building Block For Compounds With Gastric Acid-Inhibiting Activity
    作者:Mittelbach,Martin; Et Al
    参考文献:Acta Chemica Scandinavica 日期:1988 卷标:42(8) 页码:524-9]

    86604-79-7 = 86604-80-0
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol; 3.5 H,Reflux; Reflux -> Rt1.2 Reagents: Sulfuric Acid Solvents: Water; Ph 8
    标题:Synthesis Of 2-Chloromethyl-4-Methoxy-3,5-Dimethylpyridine Hydrochloride
    作者:Dai,Guiyuan; Et Al
    参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2004 卷标:35(5) 页码:261-262]

    86604-79-7 = 86604-80-0
    反应条件:1.1 Reagents: Sodium; 5 H,Reflux
    标题:Improvement On The Synthesis Of 2-Chloromethyl-4-Methoxy-3,5-Dimethylpyridine
    作者:Ma,Nan; Et Al
    参考文献:Hecheng Huaxue 日期:2007 卷标:15(3) 页码:385-387]

    109371-20-2 = 86604-80-0
    反应条件:1.1 Reagents: Sodium Methoxide Solvents: Methanol
    标题:Synthesis Of 4-Methoxy-2,3,5-Trimethylpyridine: A Specific Building Block For Compounds With Gastric Acid-Inhibiting Activity
    作者:Mittelbach,Martin; Et Al
    参考文献:Acta Chemica Scandinavica 日期:1988 卷标:42(8) 页码:524-9]

    86604-79-7 = 86604-80-0
    反应条件:1.1 Solvents: Methanol
    标题:A New Method For The Synthesis Of 4-Methoxyl-2,3,5-Trimethylpyridine
    作者:Liu,Tian-Chun; Et Al
    参考文献:Youji Huaxue 日期:2002 卷标:22(2) 页码:135-137]

    86604-79-7 = 86604-80-0 [标题:Reaction Conditions
    标题:Integrating Hydrogen Production With Anodic Selective Oxidation Of Sulfides Over A Cofe Layered Double Hydroxide Electrode
    作者:Ma,Lina; Et Al
    参考文献:Chemical Science 日期:2021 卷标:12(3) 页码:938-945]

    109371-20-2 = 86604-80-0
    反应条件:1.1 Reagents: Sodium Hydride Solvents: Dimethylformamide; 2 H,95 °C1.2 Reagents: Hydrochloric Acid Solvents: Water; Neutralized
    标题:Image-Guided Development Of Heterocyclic Sulfoxides As Ligands For Tau Neurofibrillary Tangles: From First-In-Man To Second-Generation Ligands
    作者:Rafique,Waqas; Et Al
    参考文献:Acs Omega 日期:2018 卷标:3(7) 页码:7567-7579]

    109371-20-2 = 86604-80-0
    反应条件:1.1 Reagents: Sodium Hydroxide
    标题:Diversified Synthesis Of Novel Quinoline And Dibenzothiazepine Derivatives Using Known Active Intermediates
    作者:Sharada,L. N.; Et Al
    参考文献:Asian Journal Of Chemistry 日期:2013 卷标:25(14) 页码:7959-7966]

    109371-20-2 = 86604-80-0
    反应条件:1.1 Reagents: Sodium Hydroxide
    标题:Simple,Convergent Synthesis Of The Piperazine-Linked Pyridine Derivatives: Microwave,Sonication And Conventional Methods
    作者:Sharada,L. N.; Et Al
    参考文献:Journal Of Pharmacy Research (Gurgaon 日期:2013 卷标:7(1) 页码:107-112]

    695-98-7 = 86604-80-0
    反应条件:1.1 Reagents: Hydrogen Peroxide2.1 Reagents: Nitric Acid3.1 -
    标题:Integrating Hydrogen Production With Anodic Selective Oxidation Of Sulfides Over A Cofe Layered Double Hydroxide Electrode
    作者:Ma,Lina; Et Al
    参考文献:Chemical Science 日期:2021 卷标:12(3) 页码:938-945]

    74409-42-0 = 86604-80-0
    反应条件:1.1 Reagents: Nitric Acid2.1 -
    标题:Integrating Hydrogen Production With Anodic Selective Oxidation Of Sulfides Over A Cofe Layered Double Hydroxide Electrode
    作者:Ma,Lina; Et Al
    参考文献:Chemical Science 日期:2021 卷标:12(3) 页码:938-945]

    109371-16-6 = 86604-80-0
    反应条件:1.1 Reagents: Phosphorus Oxychloride2.1 Reagents: Hydrogen,Sulfuric Acid Catalysts: Palladium Solvents: Ethanol3.1 Reagents: Methanol,Potassium Hydroxide Solvents: Dimethyl Sulfoxide4.1 Reagents: Hydrogen Peroxide Solvents: Acetic Acid,Water
    标题:Synthesis Of 4-Methoxy-2,3,5-Trimethylpyridine: A Specific Building Block For Compounds With Gastric Acid-Inhibiting Activity
    作者:Mittelbach,Martin; Et Al
    参考文献:Acta Chemica Scandinavica 日期:1988 卷标:42(8) 页码:524-9]

    609-14-3 = 86604-80-0
    反应条件:1.1 Reagents: Ammonia Solvents: Ammonia2.1 Reagents: Sodium Solvents: Ethanol,Toluene2.2 Solvents: Toluene3.1 Reagents: Phosphorus Oxychloride4.1 Reagents: Hydrogen,Sulfuric Acid Catalysts: Palladium Solvents: Ethanol5.1 Reagents: Hydrogen Peroxide Solvents: Acetic Acid,Water6.1 Reagents: Sodium Methoxide Solvents: Methanol
    标题:Synthesis Of 4-Methoxy-2,3,5-Trimethylpyridine: A Specific Building Block For Compounds With Gastric Acid-Inhibiting Activity
    作者:Mittelbach,Martin; Et Al
    参考文献:Acta Chemica Scandinavica 日期:1988 卷标:42(8) 页码:524-9
📜2,4-二氯-3,5,6-三甲基吡啶置于palladium On Activated Charcoal 硫酸,氢气,双氧水体系中,用 甲醇,乙醇,溶剂黄146 作为反应溶剂,20.0~90.0 °C,200.0 Kpa 条件下,反应 22.0H,反应生成 4-甲氧基-2,3,5-三甲基吡啶-N-氧化物
参考文献:Mittelbach; Schmidt; Uray,Acta Chemica Scandinavica. Series B: Organic Chemistry And Biochemistry,1988,Vol. 42,# 8,P. 524-529
标题:Mittelbach; Schmidt; Uray,Acta Chemica Scandinavica. Series B: Organic Chemistry And Biochemistry,1988,Vol. 42,# 8,P. 524-529

海关参考信息

专利信息


专利号:US-8173817-B2
优先权日:2004-05-28
标 题 :Stereoselective synthesis of benzimidazole sulfoxides
发明人：REDDY BANDI PARTHASARADHI; REDDY KURA RATHNAKAR; REDDY RAPOLU RAJI; REDDY DASARI MURALIDHARA
权利人:REDDY BANDI PARTHASARADHI; REDDY KURA RATHNAKAR; REDDY RAPOLU RAJI; REDDY DASARI MURALIDHARA; HETERO DRUGS LTD
摘要:The present invention relates to a process for stereoselective synthesis of substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazole is reacted with (R)-camphorsulfonyl chloride to form a mixture of 1-(R)-camphorsulfonyl-5- (and 6-)methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]-1H-benzimidazole, oxidized to obtain a diastereomeric excess of 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole over 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R)-sulfinyl]-1H-benzimidazole, the diastereomers are separated by fractional crystallization and the separated 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole is deprotected to give esomeprazole.

专利号:US-6437139-B1
优先权日:1997-05-06
标题 :Synthesis of pharmaceutically useful pyridine derivatives
发明人：ZOGHBI MICHEL; CHEN LIQUIN
权利人:PDI RES LAB INC
摘要:A process is provided for the preparation of compounds of formula I,useful in the preparation of compounds such as Omeprazole, Lansoprazole and Pantoprazole, wherein R1=H or CH3, R2=H or CH3, R3=Alkoxy (1-4C), OCH2CF3, Cyano, Hydrogen, Halogen, Acetoxy or Aryloxy, any electron withdrawing group or salts (organic or inorganic) of electron donating groups, R=Alkoxy, Hydroxy, Halogen, Activated ester, Tosylate, Mesylate, Thiol or Xanthyl, wherein the process for the preparation of compound of formula I employs a free radical reaction to functionalize the 2-position.

专利号:US-2006166986-A1
优先权日:2004-05-28
标题 :Novel stereoselective synthesis of benzimidazole sulfoxides

专利号:US-2008076930-A1
优先权日:2004-05-28
标题 :Novel stereoselective synthesis of benzimidazole sulfoxides

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合成参考文献


参考文献:10.1007/s10337-025-04444-1
摘要:Li W, Zhang Z, Wang X, Sun C, Liu Z, Ma X, Qiao Z, Zhu H, Han L. Determination of Potential Genotoxic Impurities in Esomeprazole Magnesium by HPLC–MS/MS. Chromatographia. 2025 Oct 03;88(11-12):891–903. doi: 10.1007/s10337-025-04444-1.
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