CAS: 859166-87-3; (4-Fluoropyridin-2-yl)Methanamine
该化合物是一种氟虫胺衍生物,在环的2位置上具有氨基甲基替代成分,该化合物是制药和农用化学合成的多用途建筑块,氟原子可增强代谢稳定性和生物利用率.主要含汞功能允许进一步衍生,使氨化物,非丁胺或其他含氮的乙型循环体得以形成.其硬性丙烯核心有助于改进目标相互作用的结合性,使其在药物发现药物的药用化学中具有价值.电排氟化合物的替代成分还影响再活性,便利选择性的改变.由于潜在的敏感性,在惰性条件下使用是合适的.
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上下游产品
4-氟吡啶-2-甲腈 4-Fluoropyridine-2-Carbonitrile 847225-56-3合成工艺路线路线简述
📜3-(2-Fluoro-Pyridin-4-yl)-Benzaldehyde置于吡啶,乙酸酐,水,Tin(Ll) Chloride体系中,用 二氯甲烷,Dmf (N,N-Dimethyl-Formamide) 作为反应溶剂,化学反应 26.0H,反应生成 2-氨甲基-4-氟吡啶
参考文献: Ornithine Derivatives As Prostaglandin E2 Agonists Or Antagonists[fr] Derives D'Ornithine Utilises Comme Agonistes Ou Antagonistes De La Prostaglandine E2
标题: Ornithine Derivatives As Prostaglandin E2 Agonists Or Antagonists[fr] Derives D'Ornithine Utilises Comme Agonistes Ou Antagonistes De La Prostaglandine E2
海关参考信息
- 2933310010-吡啶
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:EP-1875239-B1
优先权日:2005-04-27
标题 :A method for the preparation of imaging probes using click chemistry
发明人：KOLB HARTMUTH C; MOCHARLA VANI P; WALSH JOSEPH C
权利人:SIEMENS MEDICAL SOLUTIONS
摘要:The invention provides a method for identifying a candidate imaging probe, the method comprising: a) contacting a first library of candidate compounds with a target biomacromolecule, b) identifying a first member from the first library exhibiting affinity for the first binding site; c) contacting the first member identified from the first library affinity for the first binding site with the target biomacromolecule; d) contacting a second library of candidate compounds with the first member and the target biomacromolecule, e) reacting the complementary first functional group with the second functional group via a biomacromolecule induced click chemistry reaction to form the candidate imaging probe; f) isolating and identifying the candidate imaging probe; g) preparing the candidate imaging probe by chemical synthesis; and h) for imaging applications, converting the candidate imaging probe into an imaging probe.
