CAS: 824-40-8; Picolinic Acid N-Oxide

该化合物是皮科lin酸的衍生物,其特点是存在N-氧化功能组,该化合物一般是白色的,白色的晶状固体,在水和酒精等极地溶剂中可以溶解.N-NO,因其在生物系统中的作用而闻名,特别是在金属离子切热中,它可能与金属离子结合,从而可能影响其生物利用率和活动.该化合物显示出由于氨-氧化酸组而出现的中度酸性,其N-氧化功能可能影响其再活动及其与其他分子的相互作用.在应用方面,该化合物可能被用于研究环境,特别是在与化学和生物化学协调有关的研究中.安全数据表明,与许多有机化合物一样,它应当经过适当的安全协议来处理,以减轻任何潜在的健康风险.

英文名称Picolinic Acid N-Oxide
中文名称吡啶-2-羧酸N-氧化物
IUPAC名称2-carboxypyridine 1-oxide
其它别名Picolinicacid, 1-oxide (6CI,7CI,8CI); 1-Oxopicolinic acid; 2-Carboxylicacid-pyridine-1-oxide; 2-Carboxypyridine N-oxide; Picolinic acidN-oxide; Pyridine-2-carboxylic acid N-oxide
CAS编号824-40-8
MFCD编号:MFCD00006198
EINECS号:212-528-0
分子式:C6H5NO3
分子量:139.11
产品CID: 1815132
产品分类有机原料→通用试剂→氧化剂→其他氧化剂

相似结构搜索
产品信息参考;;;;
InChIKey: FHYMLBVGNFVFBT-UHFFFAOYSA-N
InChI=1S/C6H5NO3/c8-6(9)5-3-1-2-4-7(5)10/h1-4H,(H,8,9)…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数1.0

相似化合物

931-19-1 1073-23-0 2398-81-4

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
急性毒性类别4(经口)
严重眼刺激类别2A
警示词Warning(警告)
危险描述H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H302 |吞咽有害.
防范说明P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明26-36
危险类别码36/37/38
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

98-98-6 = 824-40-8
反应条件:1.1 Reagents: M-Chloroperbenzoic Acid Solvents: Dichloromethane; 20 Min,0 °C; 50 Min,0 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; 0 °C -> Rt
标题:Ligands For Copper-Catalyzed C-N Bond Forming Reactions With 1 Mol% Cubr As Catalyst
作者:Yang,Kai; Et Al
参考文献:Journal Of Organic Chemistry 日期:2011 卷标:76(9) 页码:3151-3159]

98-98-6 = 824-40-8
反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Tungstate(7-),Nonadeca-μ-Oxoundecaoxo(μ-Oxotetraoxodimolybdate)[μ11-[phosphato(... Solvents: Carbon Tetrachloride,Water; 6 H,Reflux
标题:Catalytic N-Oxidation Of Picolinic Acid In The Presence Of Heteropoly Acids Containing Molybdenum And Tungsten
作者:Bamoharram,Fatemeh F.; Et Al
参考文献:Journal Of Molecular Catalysis A: Chemical 日期:2007 卷标:267(1-2) 页码:241-244]

1008-89-5 = 824-40-8
反应条件:1.1 Reagents: Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Catalysts: Ruthenium Trichloride Solvents: Water-D2; 20 H,50 °C
标题:Co(Ii),A Catalyst For Selective Conversion Of Phenyl Rings To Carboxylic Acid Groups
作者:Sinha,Shashi Bhushan; Et Al
参考文献:Rsc Advances 日期:2014 卷标:4(90) 页码:49395-49399]

109-06-8 = 824-40-8
反应条件:1.1 Reagents: Permanganic Acid (Hmno4),Potassium Salt (1:1) Solvents: Water; Rt -> 70 °C; 70 °C; 30 Min,75 - 85 °C2.1 Reagents: Hydrogen Ion2.2 Reagents: Hydrogen Peroxide Solvents: Acetic Acid,Water; Cooled; 24 H,70 - 75 °C
标题:Synthesis Of 4-Nitro-2-Pyridinecarboxylic Acid Hydrazide 1-Oxide
作者:Shi,Li-Xin
参考文献:Shangqiu Shifan Xueyuan Xuebao 日期:2007 卷标:23(6) 页码:70-72]

1452-63-7 = 824-40-8
反应条件:1.1 -2.1 Reagents: Hydrogen Peroxide
标题:Stable Diacylhydrazines
作者:Talik,Tadeusz; Et Al
参考文献:Prace Naukowe Akademii Ekonomicznej Imienia Oskara Langego We Wroclawiu 日期:1984 卷标:255 页码:131-6]

4467-06-5 = 824-40-8
反应条件:1.1 Reagents: Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Catalysts: Borate(1-),Tetrafluoro-,Cobalt(2+) (2:1) Solvents: Water-D2; 3 H,50 °C2.1 Reagents: Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Catalysts: Borate(1-),Tetrafluoro-,Cobalt(2+) (2:1) Solvents: Water-D2; 4 H,40 °C
标题:Co(Ii),A Catalyst For Selective Conversion Of Phenyl Rings To Carboxylic Acid Groups
作者:Sinha,Shashi Bhushan; Et Al
参考文献:Rsc Advances 日期:2014 卷标:4(90) 页码:49395-49399]

5957-90-4 = 824-40-8
反应条件:1.1 Reagents: Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Catalysts: Borate(1-),Tetrafluoro-,Cobalt(2+) (2:1) Solvents: Water-D2; 3 H,50 °C2.1 Reagents: Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Catalysts: Borate(1-),Tetrafluoro-,Cobalt(2+) (2:1) Solvents: Water-D2; 4 H,40 °C
标题:Co(Ii),A Catalyst For Selective Conversion Of Phenyl Rings To Carboxylic Acid Groups
作者:Sinha,Shashi Bhushan; Et Al
参考文献:Rsc Advances 日期:2014 卷标:4(90) 页码:49395-49399]

98-98-6 = 824-40-8
反应条件:1.1 Reagents: Peracetic Acid,Hydrogen Peroxide Solvents: Acetic Acid,Methanol
标题:N-Oxide Substituted Picolinic Acids
作者:Profft,E.; Et Al
参考文献:Journal Fuer Praktische Chemie (Leipzig) 日期:1961 卷标:13 页码:58-75]

2524-52-9 = 824-40-8
反应条件:1.1 Reagents: Peracetic Acid,Hydrogen Peroxide Solvents: Acetic Acid
标题:Derivatives Of Picolinic Acid N-Oxide
作者:Krause,Hans Walter; Et Al
参考文献:Chemische Berichte 日期:1959 卷标:92 页码:155-60]

840-79-9 = 824-40-8
反应条件:1.1 Reagents: Hydrogen Peroxide
标题:Stable Diacylhydrazines
作者:Talik,Tadeusz; Et Al
参考文献:Prace Naukowe Akademii Ekonomicznej Imienia Oskara Langego We Wroclawiu 日期:1984 卷标:255 页码:131-6]

1452-77-3 = 824-40-8
反应条件:1.1 Reagents: Hydrogen Peroxide Solvents: Acetic Acid
标题:Synthesis Of Compounds For Chemotherapy Of Tuberculosis. Vii. Pyridine N-Oxides With Sulfur-Containing Groups
作者:Gardner,T. S.; Et Al
参考文献:Journal Of Organic Chemistry 日期:1957 卷标:22 页码:984-6]

25108-36-5 = 824-40-8
反应条件:1.1 Reagents: Hydrogen Ion1.2 Reagents: Hydrogen Peroxide Solvents: Acetic Acid,Water; Cooled; 24 H,70 - 75 °C
标题:Synthesis Of 4-Nitro-2-Pyridinecarboxylic Acid Hydrazide 1-Oxide
作者:Shi,Li-Xin
参考文献:Shangqiu Shifan Xueyuan Xuebao 日期:2007 卷标:23(6) 页码:70-72]

75003-55-3 = 824-40-8
反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Acetic Acid
标题:Studies On Tertiary Amine Oxides. Lxvii. Reactions Of Aromatic N-Oxides With 3-Arylrhodanines In The Presence Of Acetic Anhydride
作者:Yousif,Mohammed M.; Et Al
参考文献:Journal Of Heterocyclic Chemistry 日期:1980 卷标:17(2) 页码:305-9]

109-06-8 = 824-40-8
反应条件:1.1 Reagents: Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Catalysts: Borate(1-),Tetrafluoro-,Cobalt(2+) (2:1) Solvents: Water-D2; 4 H,70 °C2.1 Reagents: Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Catalysts: Borate(1-),Tetrafluoro-,Cobalt(2+) (2:1) Solvents: Water-D2; 4 H,40 °C
标题:Co(Ii),A Catalyst For Selective Conversion Of Phenyl Rings To Carboxylic Acid Groups
作者:Sinha,Shashi Bhushan; Et Al
参考文献:Rsc Advances 日期:2014 卷标:4(90) 页码:49395-49399]

127406-56-8 = 824-40-8
反应条件:1.1 Reagents: Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Catalysts: Borate(1-),Tetrafluoro-,Cobalt(2+) (2:1) Solvents: Water-D2; 4 H,50 °C2.1 Reagents: Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4) Catalysts: Borate(1-),Tetrafluoro-,Cobalt(2+) (2:1) Solvents: Water-D2; 4 H,40 °C
标题:Co(Ii),A Catalyst For Selective Conversion Of Phenyl Rings To Carboxylic Acid Groups
作者:Sinha,Shashi Bhushan; Et Al
参考文献:Rsc Advances 日期:2014 卷标:4(90) 页码:49395-49399]

1121-60-4 = 824-40-8 + 98-98-6
反应条件:1.1 Reagents: Sodium Acetate,Hydrogen Peroxide Catalysts: Acetone,Manganese Perchlorate Hexahydrate Solvents: Acetone; Cooled; 16 H,Rt
标题:Manganese Catalyzed Cis-Dihydroxylation Of Electron Deficient Alkenes With H2O2
作者:Saisaha,Pattama; Et Al
参考文献:Organic & Biomolecular Chemistry 日期:2010 卷标:8(19) 页码:4444-4450]

100-70-9 = 824-40-8 + 2402-98-4
反应条件:1.1 Reagents: Hydrogen Peroxide Catalysts: Tungstate(8-),(Aquadizincate)Tetracosa-μ-Oxotetra-μ4-Oxoundecaoxoundeca-,Ammon... Solvents: Water; 4 H,353 K
标题:A Water Soluble Heteropolyoxotungstate As A Selective,Efficient And Environment Friendly Oxidation Catalyst
作者:Maity,Prasenjit; Et Al
参考文献:Journal Of Chemical Sciences (Bangalore 日期:2009 卷标:121(4) 页码:377-385]

1121-60-4 = 824-40-8 + 76037-09-7 + 7216-40-2
反应条件:1.1 Reagents: Dimethyldioxirane Solvents: Acetone
标题:Dioxirane Epoxidation Of Alkenes
作者:Adam,Waldemar; Et Al
参考文献:Organic Reactions (Hoboken 日期:2002 卷标:61]

1121-60-4 = 824-40-8 + 98-98-6 + 76037-09-7 + 7216-40-2
反应条件:1.1 Reagents: Dimethyldioxirane Solvents: Acetone
标题:Dioxirane Epoxidation Of Alkenes
作者:Adam,Waldemar; Et Al
参考文献:Organic Reactions (Hoboken 日期:2002 卷标:61

2-吡啶甲酸置于oxone,Cobalt(II) Tetrafluoroborate Hexahydrate体系中,用重水作为反应溶剂,化学反应 4.0H,以60%的收率获得产物皮考林羧酸 N-氧化物
参考文献:Co(II),A Catalyst For Selective Conversion Of Phenyl Rings To Carboxylic Acid Groups
标题:Co(II),A Catalyst For Selective Conversion Of Phenyl Rings To Carboxylic Acid Groups
摘要:我们描述了在oxone存在下使用co(II)有效催化将-C6H5转化为-Cooh基团,具有广泛的底物范围,选择性和温和条件.
DOI:10.1039/c4Ra10510A

海关参考信息

2905110000-甲醇
2912110000-甲醛
2915110000-甲酸
2933310010-吡啶
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:NO-318910-B1
优先权日:1998-12-23
标题:Protease inhibitors, method of synthesis and use thereof, and pharmaceutical composition

专利号:PT-91036-B
优先权日:1988-07-04
标题 :PROCESS FOR THE PREPARATION OF SULFONYL-INDOLIZIN DERIVATIVES, UTEIS AS SYNTHESIS INTERMEDIARIES