CAS: 73583-39-8; 3-Bromo-5-Chloropyridine

上下游产品

CAS号26163-03-1 2-氨基-3-溴-5-氯吡啶 | CAS号137628-17-2 2,3-二溴-5-氯吡啶 | CAS号1064678-66-5 3-溴-5-氯吡啶-4-羧醛 | CAS号865186-94-3 5-氯吡啶-3-硼酸频哪醇酯

2-氨基-3-溴-5-氯吡啶置于三甲基氯硅烷,氢溴酸,溴,Sodium Iodide,Sodium Nitrite体系中,用 水 作为反应溶剂,化学反应 0.75H,反应生成 3-溴-5-氯吡啶
参考文献:制备卤代吡啶羧酸异构体的物流灵活性
标题:制备卤代吡啶羧酸异构体的物流灵活性
摘要:尽管有许多可能的方法可以选择性地在所有三个空位上官能化(特别是羧化)2-氯-4-(三氟甲基)吡啶,但是更直接的方法是仅制备2-氯-4-(三氟甲基)吡啶-3来自该前体的-羧酸(1)和来自另一个的另一个6-氯-4-(三氟甲基)吡啶-2-和-3-羧酸(2和3),即.5-溴-2-氯-4-(三氟甲基)吡啶.以相同的方式,它被证明更方便的5-氯-2-(三氟甲基)吡啶转化仅在两个相应的酸的(6和7),并以使第三个(8)由3-溴-5-氯-2-(三氟甲基)吡啶作为替代原料.通过原位产生的(三氟甲基)铜通过重卤素置换,可以容易地从相应取代的氯碘吡啶中获得所有用于官能化的模型底物.
DOI:10.1016/j.Tet.2004.09.106

专利信息

专利号:US-9549917-B2
优先权日:2011-09-08
标 题 :Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
发明人：MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; LAI ZHONG; DANG QUN; ZORN NICOLAS
权利人:MCCOMAS CASEY C; LIVERTON NIGEL J; HABERMANN JOERG; KOCH UWE; NARJES FRANK; LI PENG; PENG XUANJIA; SOLL RICHARD; WU HAO; PALANI ANANDAN; DAI XING; LIU HONG; HE SHUWEN; LAI ZHONG; DANG QUN; ZORN NICOLAS; MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-5436344-A
优先权日:1990-11-29
标 题:3-bromo-5-chloro-pyridines used as intermediates in the synthesis of azatetralones