CAS: 7148-03-0; 4'-Methyl-[1,1'-Biphenyl]-2-Carboxylic Acid

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CAS号114772-53-1 2-氰基-4'-甲基联苯 | CAS号114772-34-8 2-(对甲苯基)苯甲酸甲酯 | CAS号88-67-5 邻碘苯甲酸 | CAS号5720-05-8 对甲基苯基硼酸 | CAS号88-65-3 邻溴苯甲酸 | CAS号16191-28-9 4-甲基-联苯-2-甲醛 | CAS号131-62-4 1-羟基-1,2-苯碘酰-3(1H)-酮 | CAS号40881-45-6 Dimethyl (4-met... | CAS号195062-57-8 4,4,5,5-四甲基-2-(... | CAS号84392-32-5 4,4-二甲基-2-(4'-甲... | CAS号114772-38-2 2-[4-(溴甲基)苯基]苯甲酸甲酯 | CAS号114772-34-8 2-(对甲苯基)苯甲酸甲酯 | CAS号114772-40-6 4'-溴甲基联苯-2-甲酸叔丁酯 | CAS号114772-36-0 4'-甲基-[1,1'-联苯]... | CAS号1204-43-9 4-甲基-联苯-2-胺 | CAS号114772-53-1 2-氰基-4'-甲基联苯 | CAS号16191-28-9 4-甲基-联苯-2-甲醛 | CAS号150766-86-2 4'-(溴甲基)-[1, 1'... | CAS号114772-35-9 2-(4-methylphen... | CAS号114798-32-2 2-[4-[[2-but-1-...

邻甲氧基苯甲酸置于水,三氟乙酸酐体系中,用 乙醚,乙醇,甲苯,苯 作为反应溶剂,化学反应 44.0H,反应生成 4'-甲基联苯-2-羧酸
参考文献:Practical Synthesis Of 4'-Methylbiphenyl-2-Carboxylic Acid
标题:Practical Synthesis Of 4'-Methylbiphenyl-2-Carboxylic Acid
摘要:在乙醚-苯体系中,将2,6-二叔丁基-4-甲基苯甲酸甲氧基苯酯(5)与4-甲基苯基溴化镁(6)反应,通过酯辅助的亲核芳香取代(snar)反应,以优异的收率获得产物4'-甲基联苯-2-羧酸乙酯(7).接着,通过在甲苯-1-甲基-2-吡咯烷酮中用甲醇钠处理后进行水解,4'-甲基联苯-2-羧酸乙酯(7)可迅速且定量地转化为4'-甲基联苯-2-羧酸(2A).
DOI:10.1055/s-1995-3851

专利信息

专利号:US-7968727-B2
优先权日:2005-04-01
标 题 :Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists
发明人：COPAR ANTON; ANTONCIC LJUBOMIR; ANTONCIC MATEJ
权利人:LEK PHARMACEUTICALS
摘要:4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl are useful starting material for the preparation various angiotenzin II antagonists, which are prepared from 4-bromomethyl-2′-cyanobiphenyl or 4′-bromomethylbiphenylcarboxyilic derivatives using selected hydride reagent.

专利号:IT-MI990749-A1
优先权日:1999-04-13
标题 :METHOD FOR THE SYNTHESIS OF DERIVATIVES OF 2-4-METHYLPHENYL BENZOIC ACID

专利号:US-2009318521-A1
优先权日:2005-04-01
标题 :Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists

专利号:EP-0978503-B1
优先权日:1998-08-05
标 题 :Synthesis of t-butyl o-(p-tolyl)benzoate by reaction of o-(p-tolyl)benzoic acid with isobutene using acid catalysis
发明人：MEUDT ANDREAS DR; NOERENBERG ANTJE DR; HABER STEFFEN DR
权利人:CLARIANT GMBH

专利号:WO-03066565-A1
优先权日:2002-02-07
标题 :Deuterated biphenyl derivatives
发明人：ALKEN RUDOLF-GIESBERT
权利人:BDD GROUP HOLDING AG; ALKEN RUDOLF-GIESBERT
摘要:The invention relates to deuterated biphenyl derivatives and deuterated precursors for the production of said compounds. Deuterated biphenyl derivatives are important intermediate products in the synthesis of medicaments which can, for example, be used in the treatment of circulatory disturbances, high blood pressure and heart diseases. .

专利号:WO-2006103068-A1
优先权日:2005-04-01
标题:A synthesis of 4-bromomethyl-2'-formylbiphenyl and 4-bromomethyl-2'- hydroxymethylbiphenyl and its use in preparation of angiotensin ii antagonists