专利号:WO-2015058868-A1 优先权日:2013-10-25 标题 :Compositions and methods for the treatment of cancer 发明人:JIMENO DOÑAQUE JOSÉ Mª 权利人:PANGAEA BIOTECH S L 摘要:The invention relates to anti-tumor compounds which have been designed to functionally disrupt the cross-talk between AEG-1 and the p65 subunit of NF-κB. Therefore, the invention relates to methods and compositions for the treatment of cancer using the compounds identified in the present invention, as well as compositions adequate for sustained release of the compounds of the invention to be administered to the surgical site after resection of the tumor. The invention also provides methods for the synthesis of the compounds of the invention.
专利号:KR-20220169970-A 优先权日:2021-06-21 标题 :Method for synthesis of aminobenzyne and multisubstituted organic nitrogen compounds using aza-brook rearrangement and multisubstituted organic nitrogen compounds prepared using the same
专利号:CN-112169836-A 优先权日:2020-09-28 标 题:A kind of porous ionic polymer heterogeneous catalyst and method for catalyzing the synthesis of N-formamide
专利号:US-2012009151-A1 优先权日:2007-12-21 标题 :Triazines And Related Compounds Having Antiviral Activity, Compositions And Methods Thereof 发明人:HAN AMY QI; COBURN GLEN A; PROVONCHA KATHLEEN P; ROTSHTEYN YAKOV 权利人:HAN AMY QI; COBURN GLEN A; PROVONCHA KATHLEEN P; ROTSHTEYN YAKOV; PROGENICS PHARM INC 摘要:Disclosed herein are novel triazines and related compounds, the synthesis thereof, and compositions, including pharmaceutical compositions, comprising the novel triazines and related compounds. Such novel triazines and related compounds function to inhibit or block entry of viruses of the Flaviviridae family, including Hepatitis C virus (HCV), into cells that are susceptible to virus infection. These compounds are useful for the treatment, therapy and/or prophylaxis of viral diseases and infection, including HCV infection.
专利号:US-6207836-B1 优先权日:1993-02-17 标 题 :Indolin-2-one derivatives 发明人:ESAKI TORU; EMURA TAKASHI; HOSHINO EIICHI 权利人:CHUGAI PHARMACEUTICAL CO LTD 摘要:A compound represented by formula (I):wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, an alkoxy group, an acyl group, an aryl group or a heterocyclic group; R3 represents a lower alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, -OR5, -SR5 or -NR6R7 (wherein R5, R6, and R7 each represent a lower alkyl group, etc.); X and Y each represent -CH2-, -NH- or -O-; and n represents an integer of from 0 to 4, and an intermediate for synthesis thereof are disclosed. The compound of the present invention exhibits selective antagonism against gastrin receptors without causing side effects attributed to CCK-A receptor antagonism and is useful for the treatment and prevention of peptic ulcers, gastritis, reflux esophagitis, and Zollinger-Ellison syndrome, and for the treatment of neoplasm originating in the gastrointestinal system.
专利号:CN-109836365-A 优先权日:2019-01-15 标题 :A class of amine thioacyl fluoride derivatives and synthesis method thereof
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 182. 摘要:Zhang, H.; Liu, C.; Lei, A., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 164.