CAS: 6575-09-3; 2-Chloro-6-Methylbenzonitrile

该化合物是一种有机化合物,其特点是芳香结构,包括一个以氯原子和硝三烯组组成的苯环替代的苯环,在2位和6位苯环位置的甲基组物的存在有助于其独特的化学特性.该化合物一般是无色的,可粉黄的液体或固体,视温度和纯度而定.该化合物以其在有机溶剂中的中等溶解性而闻名,同时由于芳香环的疏水性而较少溶于水中. 2-Chroloo-6-甲基苯甲三烯被各种化学合成物所利用,并可作为制药,农用化学品和其他有机化合物生产的中间体.该化合物的活性受硝三烯组的电镀性质和电阴性氯原子的影响,使其在有机合成中成为有用的建筑块.在处理该化合物时,应当注意安全防范,因为如果吸入或吸入,可能会对健康构成危险.

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2-amino-6-methylbenzonitrile potassium cyanide 2-chloro-6-methylaniline 2-cyano-3-nitrotoluene 2-chloro-6-methylbenzamide 2-chloro-6-chloromethyl-benzonitrile 2-Methyl-6-(2,2,2-trifluoro-ethoxy)-benzonitrile 2-chloro-6-(bromomethyl)benzonitrile

合成工艺路线路线简述

    📜邻甲基苯腈置于n-氯代丁二酰亚胺,Palladium Diacetate,对甲苯磺酸体系中,用 1,2-二氯乙烷 作为反应溶剂,化学反应 12.0H,以71%的收率获得产物2-氯-6-甲基苄腈
    参考文献:Palladium-Catalyzed Highly Selective Ortho-Halogenation (I,Br,Cl) Of Arylnitriles Via Sp2 C-h Bond Activation Using Cyano As Directing Group
    标题:Palladium-Catalyzed Highly Selective Ortho-Halogenation (I,Br,Cl) Of Arylnitriles Via Sp2 C-h Bond Activation Using Cyano As Directing Group
    摘要:A Palladium-Catalyzed Ortho-Halogenation (I,Br,Cl) Of Arylnitrile Is Described. The Optimal Reaction Conditions Were Identified After Examining Various Factors Such As Catalyst,Additive,Solvent,And Reaction Temperature. Using Cyano As The Directing Group,The Halogenation Reaction Gave Good To Excellent Yields. The Method Is Compatible To The Arylnitriles With Either Electron-Withdrawing Or Electron-Donating Groups. The Reaction Is Available To The Substrate In At Least Gram Scale. The Present Method Was Successfully Applied To The Synthesis Of The Precursors Of Paucifloral F And Isopaucifloral F.
    DOI:10.1021/jo302765G

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    合成参考文献


    参考文献:10.1007/978-3-319-44890-9_54
    摘要:Ajaypraveenkumar A, Raman RG, Sebastian S. Geometrical Structure, Vibrational Spectra, NLO, NBO, Electronic Transitions and Thermo Dynamical Analysis of 5-Fluoro-2-Methylbenzonitrile by DFT Computational Method. 2017. In: Recent Trends in Materials Science and Applications. : Springer International Publishing; 2017.
    参考文献:10.1007/s43538-022-00086-1
    摘要:Mariappan G, Beena T, Sudha L, Sundaraganesan N. Spectroscopic characterization, molecular structure, NBO analysis, dielectric studies and biological activities of 4-(3-aminophenyl) benzonitrile. Proceedings of the Indian National Science Academy. 2022 Aug 02;88(3):292–9. doi: 10.1007/s43538-022-00086-1.
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