专利号:US-6765091-B1 优先权日:1999-08-30 标题:Oligosaccharides derived from ribose-ribitol-phosphate, and vaccines containing them 发明人:BENCOMO VICENTE GUILLERMO VERE; ROY RENE 权利人:UNIV LA HABANA; UNIV OTTAWA 摘要:The present invention relates to the field of the Medicine, in particular with the chemical synthesis of oligosaccharide mixtures derived of ribose-ribitol-phosphate, which are used as active principle in vaccines for the prevention of infections caused by Haemophilus influenzae type b (Hib), as well as with the vaccines containing said oligosaccharide mixtures. n The oligasaccharide mixtures obtained by chemical synthesis of the present invention, comprise repeating units of formulae (phosphate-ribosa-ribitol)n or (ribose-ribitol-phosphate)n of at least 5 compounds of structure A or B, which represent the repeating unit of the capsular polysaccharide of Haemophilus influenzae type b and differ only by n, being n a value contained between 4 and 25 (n≧4 y≦25), and wherein R 1 or R 2 is a spacer for conjugation to a carrier, with the condition of R 1 =spacer if R 2 =H, or R 2 =spacer if R 1 =H. n The invention also is related with the immunogens containing such oligosaccharide mixtures, with the vaccines containing said immunogens and with the methods to prepare these oligosaccharides as mixtures. Furthermore, the invention includes the use of the vaccines, alone or combined with other vaccines, for the prevention of the infections caused by Haemophilus influenzae type b.
专利号:US-5786448-A 优先权日:1996-11-07 标题:Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein 发明人:NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD 权利人:TREGA BIOSCIENCES INC 摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds made by the combinatorial synthesis.
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-2008214565-A1 优先权日:2003-04-07 标 题:Oxazolidinone Derivatives as Antimicrobials 发明人:MEHTA ANITA; RUDRA SONALI; RAO AJJARAPU VENKATA SUBRAHMANYA RAJO; YADAV AJAY SINGH; RATTAN ASHOK 权利人:MEHTA ANITA; RUDRA SONALI; RAO AJJARAPU VENKATA SUBRAHMANYA RAJO; YADAV AJAY SINGH; RATTAN ASHOK 摘要:The present invention relates to certain substituted phenyl oxazolidinones of formula I and H and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
专利号:US-10968162-B2 优先权日:2018-03-30 标 题:Method for the synthesis and purification of aryl acid esters 发明人:MARSHALL JANET 权利人:UNIV MIAMI 摘要:The general inventive concepts are directed to the discovery that certain aryl acids can be esterified under particular conditions to provide the resulting ester as a solid that precipitates in good yield from the reaction mixture. The esters may then be isolated and purified with relative ease. Accordingly, a method for the esterification, isolation, and purification of aryl acids is provided.
专利号:EP-4103640-B1 优先权日:2020-02-11 标 题 :New method of synthesis of chitosan derivatives and uses thereof 发明人:KARGAPOLOV YURIY; FOMENKO VLADISLAV 权利人:NOVOCHIZOL SA
[参考文献]: María L Salum, Et Al. Combined Experimental And Computational Investigation Of The Absorption Spectra Of E- And Z-Cinnamic Acids In Solution: The Peculiarity Of Z-Cinnamics. J Photochem Photobiol B. 2015 Jul:148:128-135.
合成参考文献
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