CAS: 60032-57-7; 2-Methylnicotinaldehyde

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1721-26-2 56826-61-0 65719-09-7

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CAS号56826-61-0 3-羟甲基-2-甲基吡啶 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号38749-79-0 3-溴-2-甲基吡啶 | CAS号469864-28-6 N-methoxy-N,2-d... | CAS号1721-26-2 2-甲基烟酸乙酯 | CAS号312933-33-8 ethyl (Z)-3-(al... | CAS号90643-19-9 2-methyl-1,4-di... | CAS号65719-09-7 2-甲基烟酸甲酯 | CAS号197079-01-9 2-甲基烟酸肼 | CAS号56826-61-0 3-羟甲基-2-甲基吡啶 | CAS号154650-88-1 噻吩并[2,3-b]吡啶-2-羧酸甲酯 | CAS号120277-68-1 3-(氯甲基)-2-甲基吡啶

3-羟甲基-2-甲基吡啶置于manganese(Iv) Oxide体系中,用 二氯甲烷 作为反应溶剂,化学反应 18.0H,以99%的收率获得产物2-甲基吡啶-3-甲醛
参考文献:主链锚定固相合成策略以访问含有肽尿苷的小分子库
标题:主链锚定固相合成策略以访问含有肽尿苷的小分子库
摘要:核苷二磷酸糖(ndp-糖)底物为核苷类似物抑制剂支架提供了灵感.通过采用固相合成,我们提供了一种使用最少的化合物处理和纯化步骤来访问肽尿苷抑制剂库的方法.具体而言,该策略通过反应生成尿苷二磷酸糖 (Udp-糖) 模拟物来举例说明,该模拟物允许通过改变二肽组成,N 端连接和侧基芳基来进行复合加工.为了举例说明多功能性,提出了 41 种独特的核苷类似物.
DOI:10.1021/acs.Orglett.2C00462

专利信息

专利号:US-2005009055-A1
优先权日:2002-07-12
标 题 :System and method for examination of microarrays using scanning electron microscope
发明人：CICCOLELLA PAUL C; HOZBOR MARIA A
权利人:AFFYMETRIX INC
摘要:The present invention provides methods to detect biomolecules on a microarray using a scanning electron microscope. In one embodiment of the invention, errors in oligonucleotide synthesis during manufacturing of microarrays are detected by monitoring synthesis of control probes on the chips. In another embodiment, misalignment of features on the chip is determined. In yet another embodiment, the size, shape and edge definition of features on the chip is determined. In further embodiments, methods are provided for analyzing interactions between an oligonucleotide target and an oligonucleotide probe on a microarray and methods for testing conditions in a microarray manufacturing process.

专利号:US-2004081985-A1
优先权日:2002-07-12
标题:Systems and method for examination of microarrays using scanning electron microscope
发明人：CICCOLELLA PAUL C; HOZBOR MARIA A
权利人:AFFYMETRIX INC
摘要:The present invention provides methods to detect biomolecules on a microarray using a scanning electron microscope. In one embodiment of the invention, errors in oligonucleotide synthesis during manufacturing of microarrays are detected by monitoring synthesis of control probes on the chips. In another embodiment, misalignment of features on the chip is determined. In yet another embodiment, the size, shape and edge definition of features on the chip is determined. In further embodiments, methods are provided for analyzing interactions between an oligonucleotide target and an oligonucleotide probe on a microarray and methods for testing conditions in a microarray manufacturing process.

专利号:US-2006025421-A1
优先权日:2004-06-25
标 题:Pyridyl piperazines for the treatment of CNS disorders
发明人：BRODNEY MICHAEL A
权利人:PFIZER
摘要:This invention is directed to compounds of Formula I and to pharmaceutical compositions comprising the compound of Formula I. n n where the dashed line represents an optional double bond; and where n is 1 or 2, and Ar 1 , Ar 2 , . . . and Z are as defined in the specification. The invention is also directed to a method of treating a disorder or condition that can be treated by altering serotonin-mediated neurotransmission, such as migraine, headache, cluster headache, anxiety, depression, etc. This invention is also directed to intermediates useful in the synthesis of compounds of Formula I.

专利号:US-2011152313-A1
优先权日:2008-06-20
标题 :Synthesis of ageladine a and analogs thereof
发明人：KARUSO PETER HELMUTH; SHENGULE SUDHIR RAMNATHRAO
权利人:UNIV MACQUARIE
摘要:The invention describes a one pot process for synthesizing a compound of structure (I), or a tautomer thereof. A compound of structure (II), or a tautomer thereof, and an aldehyde of structure R d CHO are condensed to form a condensation product. The resulting condensation product is then oxidized in the same reaction mixture to produce the compound of structure (I) or a tautomer thereof.

专利号:US-9994558-B2
优先权日:2013-09-20
标题 :Multicyclic compounds and methods of using same
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders (e.g., PAK-mediated, for example, PAK4-mediated, diseases and disorders).

专利号:US-2011009371-A1
优先权日:2004-05-21
标 题:Synthesis of tetracyclines and analogues thereof