CAS: 5968-70-7; (3R,4R,4Ar,6Ar,6Bs,8Ar,11R,12S,12Ar,14Ar,14Br)-3-Acetyloxy-4,6A,6B,8A,11,12,14B-Heptamethyl-2,3,4A,5,6,7,8,9,10,11,12,12A,14,14A-Tetradecahydro-1H-Picene-4-Carboxylic Acid

上下游产品

CAS号631-69-6 β-乳香酸 | CAS号67416-61-9 3-O-乙酰基-11-氧代-β-乳香酸

📜乙酰基-11-酮基-Beta-乳香酸置于platinum(Iv) Oxide,氢气,溶剂黄146体系中,25.0 °C,8.5 Mpa 条件下,反应 12.0H,以87%的收率获得产物3-乙酰基-Beta-乳香酸
参考文献:合成新的乳香酸衍生物作为潜在的抗增殖剂.
标题:合成新的乳香酸衍生物作为潜在的抗增殖剂.
摘要:在目前的研究中,制备了一系列的乳香酸杂环衍生物以及3-O-乙酰基-11-酮基-β-乳香酸(akba,1)11-酮基-β-乳香酸(kba,2)和几种新的bis-Akba和kba同型二聚体以及akba-Kba异二聚体.已经评估了这些化合物对不同人类癌细胞系,即fadu(咽癌),A2780(卵巢癌),Ht29(结肠腺癌)和a375(恶性黑色素瘤)增殖的影响.因此,Kba同型二聚体21有效抑制fadu,A2780,Ht29和a375细胞的生长,其ec 50值低于9μm .另外,化合物7,8,11,12,15,16,和17为a2780,Ht29也表现出细胞毒性作用,和a375癌细胞.尤其是,吡嗪类似物8对a375癌细胞具有高度细胞毒性,Ec 50值为2.1μm.
DOI:10.1080/14786419.2018.1564295

专利信息

专利号:US-2006234990-A1
优先权日:1999-04-30
标题 :Compositions of boswellic acids derived from Boswellia serrata gum resin, for treating lymphoproliferative and autoimmune conditions
发明人：MAJEED MUHAMMED; BADMAEV VLADIMIR
权利人:SAMI LABS LTD
摘要:A method of treatment of lymphoproliferative and autoimmune disorders with a new composition of four boswellic acids including β-boswellic acid, 3-O-acetyl-β-boswellic acid, 11-keto-β-boswellic acid, and 3-O-acetyl-11-keto-β-boswellic acid. Boswellic acids of invention have been obtained in a novel industrial process from the gum resin of Boswellia serrata tree, providing standardized composition which inhibits DNA, RNA and protein synthesis of the target cell without cytotoxic effects. The composition of invention provides advantage of irreversible cytostatic therapy, equivalent to biological effects of a cytotoxic therapy without killing body cells.

专利号:WO-2008058514-A1
优先权日:2006-11-14
标 题:Preparations comprising boswellic acids for inhibiting the synthesis of prostaglandin e2
发明人：WERZ OLIVER; SIEMONEIT ULF
权利人:UNIV EBERHARD KARLS; WERZ OLIVER; SIEMONEIT ULF
摘要:The present invention relates to the use of preparations with pentacyclic triterpenoic acids and structural derivatives thereof, in particular boswellic acids from Boswellia species (such as B. serrata, B. carterii, B. sacra), for inhibiting the inducible mitochondrial prostaglandin E₂ synthase-1. In addition, the invention relates to the use of pentacyclic triterpenoic acids and derivatives thereof for producing a medicament for the treatment of PGE₂-mediated diseases.

专利号:WO-02085921-A2
优先权日:2001-03-01
标 题 :Simple method for the synthesis of boswellic acids and derivatives thereof

专利号:DE-102006053475-A1
优先权日:2006-11-14
标题:Preparations for the inhibition of prostaglandin E2 synthesis