CAS: 5807-14-7; 2,3,4,6,7,8-Hexahydro-1H-Pyrimido[1,2-A]Pyrimidine

相似化合物

84030-20-6 99645-86-0 1695731-27-1

上下游产品

CAS号56-18-8 3,3'-二氨基二丙胺 | CAS号726-42-1 1,3-二对甲苯基碳二酰亚胺 | CAS号50-01-1 盐酸胍 | CAS号693-13-0 N,N'-二异丙基碳二亚胺 | CAS号538-75-0 N,N'-二环己基碳酰亚胺 | CAS号13173-07-4 1-(3-aminopropy... | CAS号420-04-2 氰胺 | CAS号1852-18-2 5-羟基-1,3-二嗦农-2-酮 | CAS号294-80-4 1,5,9-三氮杂环十二烷 | CAS号622-85-5 丙氧基苯 | CAS号71-36-3 正丁醇 | CAS号80509-86-0 1-butyl-2,3,4,6... | CAS号62051-24-5 nsc334066

3,3'-二氨基二丙基胺置于原碳酸四乙酯,氢溴酸,Sodium Methylate体系中,用 四氢呋喃,乙醇,二甲基亚砜 作为反应溶剂,化学反应 36.0H,反应生成 1,5,7-三氮杂双环[4.4.0]癸-5-烯
参考文献:一种7-甲基-1,5,7-三氮杂二环[4.4.0]癸-5-烯的合成方法
标题:一种7-甲基-1,5,7-三氮杂二环[4.4.0]癸-5-烯的合成方法
摘要:本发明公开了一种7‑甲基‑1,5,7‑三氮杂二环[4.4.0]癸‑5‑烯的合成方法:在四氢呋喃中3,3'‑二氨基二丙胺与氢溴酸溶液成盐,以二甲亚砜作为反应溶剂,与原碳酸四乙酯,3,3'‑二氨基二丙胺加热反应;反应结束后,加入四氢呋喃析晶,抽滤,悬洗,干燥得到中间体化合物ⅳ;然后与甲醇钠反应,游离后得到粗品化合物ⅴ,化合物ⅴ通过甲苯结晶提纯后再在碱作用下,与硫酸二甲酯反应得到粗品目标化合物ⅵ;将粗品进行减压蒸馏,收集80~85oc/55Pa馏分,得到无色透明液体.本发明制得的高纯度7‑甲基‑1,5,7‑三氮杂二环[4.4.0]癸‑5‑烯,Gc纯度能达到99%以上,总收率79%以上.

专利信息

专利号:US-9506095-B2
优先权日:2012-02-09
标 题:Process for the enzymatic synthesis of (7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid or esters thereof, and application in the synthesis of ivabradine and salts thereof
发明人：PEDRAGOSA-MOREAU SANDRINE; LEFOULON FRANÇOIS
权利人:SERVIER LAB; LES LABORATORIES SERVIER
摘要:Process for the enzymatic synthesis of the compound of formula (I): n nwherein R 1 represents a hydrogen atom or an alkyl group.n n Application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

专利号:US-10597358-B2
优先权日:2015-01-16
标题:Synthesis of carbamate or urea compounds
发明人：VAN DER HEIJDEN ANTONIUS EDUARD DOMINICUS MARIA; VAN GEEST ERIK; VAN DEN ELSHOUT JOS JOHAN MATTHIJS HUGO
权利人:TNO
摘要:The invention pertains to the synthesis of carbamate and urea compounds. In particular the invention is directed to the synthesis of carbamate and urea compounds which may be used in the production of compounds that are used to stabilize nitrocellulose. The method of the invention comprises preparing a carbamate or urea derivative comprising reacting an amine and a carbonate or carbamate in the presence of an ionic liquid.

专利号:US-11220513-B2
优先权日:2015-04-30
标题:Chromium-mediated coupling and application to the synthesis of halichondrins
发明人：KISHI YOSHITO; YAN WUMING; LI JINGWEI; LI ZHANJIE; YAHATA KENZO
权利人:HARVARD COLLEGE
摘要:The present invention provides unified synthesis of the C1-C19 building blocks of halichondrins and analogs thereof using selective coupling of poly-halogenated nucleophiles in chromium-mediated coupling reactions. The present invention also provides a practical and efficient synthesis of C20-C38 building blocks of halichondrins and analogs thereof. Also provided herein are general methods of selective activation and coupling of poly-halogenated analogs with an aldehyde. The provided coupling reactions are selective for halo-enone and halo-acetylenic ketal over vinyl halide and halide attached to a sp hybridized carbon. The provided efficient selective coupling reactions can allow easy access to the C1-C19 building blocks and C20-C38 building blocks of halichondrins and analogs thereof with limited or no purification or separation of the intermediates.

专利号:WO-2024036115-A1
优先权日:2022-08-08
标题:Continuous flow synthesis of lorazepam
发明人：THOMPSON DAVID; BIYANI SHRUTI; HYUN SEOK-HEE; MCGUIRE MICHAEL
权利人:PURDUE RESEARCH FOUNDATION; CONTINUITY PHARMA LLC
摘要:A method for synthesis of Lorazepam in a continuous flow using continuous flow reactor, in which method comprises five steps including N-acylation, diazepine ring closure, imine N- oxidation, Polonovski-type rearrangement, and ester hydrolysis; a green reagent comprising a peroxide reagent and rhenium oxide catalyst for N-oxidation of delorazepam; and an ammonium source combination for the synthesis of delorazepam.

专利号:US-8637695-B2
优先权日:2011-12-30
标 题:Synthesis of organohalosilane monomers from conventionally uncleavable Direct Process Residue
发明人：LEWIS KENRICK MARTIN; NEELY JOHN DAVID
权利人:LEWIS KENRICK MARTIN; NEELY JOHN DAVID; MOMENTIVE PERFORMANCE MAT INC
摘要:Disclosed herein is a catalytic process for the synthesis of organohalosilane monomers from tetraorganodihalodisilanes and other compounds that are not cleaved during the conventional hydrochlorination of Direct Process Residue. The process is characterized by the use of a catalyst containing (1) one or more heterocyclic amines and/or one or more heterocyclic ammonium halides, and (2) one or more quaternary Group 15 onium compounds.

专利号:US-5097089-A
优先权日:1987-08-29
标 题 :Synthesis of glycerol from formaldehyde
发明人：GRACEY BENJAMIN P; HUDSON BARRY; WILLIAMS PETER S
权利人:BP CHEM INT LTD
摘要:This invention relates to a process for synthesis of glycerol from formaldehyde, wherein formaldehyde under substantially anhydrous condition is self-condensed in a catalytic step is dihydroxyacetone which is separated from the self-condensation catalyst and hydrogenated catalytically to glycerol. n The feature of the invention is to have less than 0.4% w/w of water in the self-condensation reaction mixture thereby improving the process to produce glycerol in commercially viable rates and yields.