CAS: 56962-11-9; 2-Chloro-4-Hydroxybenzaldehyde

上下游产品

CAS号3336-16-1 2-氯-4-羟基苯腈 | CAS号108-43-0 3-氯酚 | CAS号67-66-3 氯仿 | CAS号874-42-0 2,4-二氯苯甲醛 | CAS号74-90-8 氢氰酸 | CAS号121-86-8 2-氯-4-硝基甲苯 | CAS号75-25-2 三溴甲烷 | CAS号76-03-9 三氯乙酸 | CAS号54788-17-9 2-氯4-甲氧基溴苄 | CAS号54439-75-7 2-氯-4-羟基苯甲醛 | CAS号278597-32-3 2-氯-4-[[3-(2,6-... | CAS号615-67-8 氯氢醌 | CAS号334018-24-5 2-氯-4-甲氧基苯甲醇 | CAS号117490-57-0 4-(苄氧基)-2-氯苯甲醛 | CAS号650629-11-1 2-氯-4-[2-(二甲基氨基... | CAS号848847-23-4 2-chloro-4-[3-(...

2-氯-4-羟基苯甲腈置于二异丁基氢化铝,盐酸体系中,用 四氢呋喃,正己烷,水 作为反应溶剂,化学反应 19.0H,以84%的收率获得产物2-氯-4-羟基苯甲醛
参考文献:Triazolopyridinylsulfanyl Derivatives As P38 Map Kinase Inhibitors
标题:Triazolopyridinylsulfanyl Derivatives As P38 Map Kinase Inhibitors
摘要:公式(i)的化合物,或其药学上可接受的盐和/或溶剂合物(包括水合物);以及公式(i)的化合物在治疗tnf介导的疾病,疾病或症状,或p38介导的疾病,疾病或症状中的用途,特别是过敏和非过敏的呼吸道疾病,更特别是梗阻性或炎症性呼吸道疾病,最好是慢性阻塞性肺病.

专利信息

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

专利号:US-8952042-B2
优先权日:2009-08-19
标 题 :FXR (NR1H4) binding and activity modulating compounds
发明人：KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF
权利人:KREMOSER CLAUS; ABEL ULRICH; STEENECK CHRISTOPH; KINZEL OLAF; PHENEX PHARMACEUTICALS AG
摘要:The present invention relates to compounds of formula (1): n nwhere R, A, Q and Z are defined herein, or an enantiomer, diastereomer, tautomer, solvate, prodrug or pharmaceutical acceptable salt thereof. These compounds bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.

专利号:US-5968736-A
优先权日:1992-10-01
标 题 :Methods for recording the reaction history of a solid support
发明人：STILL W CLARK; WIGLER MICHAEL H; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C
权利人:COLD SPRING HARBOR LAB; UNIV COLUMBIA
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

专利号:US-6503759-B1
优先权日:1992-10-01
标题 :Complex combinatorial chemical libraries encoded with tags
发明人：STILL W CLARK; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C; WIGLER MICHAEL H
权利人:UNIV COLUMBIA; COLD SPRING HARBOR LAB
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

专利号:US-5721099-A
优先权日:1992-10-01
标 题 :Complex combinatorial chemical libraries encoded with tags
发明人：STILL W CLARK; WIGLER MICHAEL H; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C
权利人:UNIV COLUMBIA; COLD SPRING HARBOR LAB
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

专利号:US-6001579-A
优先权日:1993-10-01
标 题 :Supports and combinatorial chemical libraries thereof encoded by non-sequencable tags
发明人：STILL W CLARK; WIGLER MICHAEL H; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C
权利人:UNIV COLUMBIA; COLD SPRING HARBOR LAB
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.